ID A0A0E0KZL1_ORYPU Unreviewed; 2445 AA.
AC A0A0E0KZL1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00013058};
DE EC=6.4.1.2 {ECO:0000256|ARBA:ARBA00013058};
OS Oryza punctata (Red rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4537 {ECO:0000313|EnsemblPlants:OPUNC05G06090.1};
RN [1] {ECO:0000313|EnsemblPlants:OPUNC05G06090.1}
RP NUCLEOTIDE SEQUENCE.
RA Wing R.;
RT "Oryza genome evolution.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:OPUNC05G06090.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] =
CC ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate;
CC Xref=Rhea:RHEA:13501, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145,
CC ChEBI:CHEBI:456216; EC=6.3.4.14;
CC Evidence={ECO:0000256|ARBA:ARBA00000861};
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
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DR STRING; 4537.A0A0E0KZL1; -.
DR EnsemblPlants; OPUNC05G06090.1; OPUNC05G06090.1; OPUNC05G06090.
DR Gramene; OPUNC05G06090.1; OPUNC05G06090.1; OPUNC05G06090.
DR eggNOG; KOG0368; Eukaryota.
DR HOGENOM; CLU_000395_5_2_1; -.
DR OMA; EEPILRH; -.
DR UniPathway; UPA00655; UER00711.
DR Proteomes; UP000026962; Chromosome 5.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45728:SF4; ACETYL-COA CARBOXYLASE 2; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000026962}.
FT DOMAIN 252..759
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 405..599
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 886..960
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1686..2027
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 2031..2345
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
FT REGION 96..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2445 AA; 270231 MW; 38FCB9A83500B8DB CRC64;
MRPWEFIILG RTAPIPPPPL GISAFSRPLR LRLAAAAAAV VDAARIQTPP RVAFSASCFF
FFFFFFFSEG ISREGTPARL PALIYRLRFI RRAPSVHSVP SPAPDPRAAR RSAPGRTTMT
STHVATLGVG AQAPPRHQKK SAGTAFVSSG SSRSSYRKNG QRTRSLREES NGGVSDSKKL
NHSIRQGLAG IIDLPNDAAS EVDISHGSED PRGPTVPGSY QMNGIINETH NGRHASVSKV
VEFCTALGGK TPIHSVLVAN NGMAAAKFMR SVRTWANDTF GSEKAIQLIA MATPEDLRIN
AEHIRIADQF VEVPGGTNNN NYANVQLIVE IAERTGVSAV WPGWGHASEN PELPDALTAK
GIVFLGPPAS SMHALGDKVG SALIAQAAGV PTLAWSGSHV EVPLECCLDS IPDEMYRKAC
VTTTEEAVAS CQVVGYPAMI KASWGGGGKG IRKVHNDDEV RTLFKQVQGE VPGSPIFIMR
LAAQSRHLEV QLLCDQFGNV AALHSRDCSV QRRHQKIIEE GPVTVAPRET VKELEQAARR
LAKAVGYVGA ATVEYLYSME TGEYYFLELN PRLQVEHPVT EWIAEVNLPA AQVAVGMGIP
LWQIPEIRRF YGMNHGGGYD LWRKTSALAT PFNFDEVDSK WPKGHCVAVR ITSEDPDDGF
KPTGGKVKEI SFKSKPNVWA YFSVKSGGGI HEFADSQFGH VFAYGTTRSA AITTMALALK
EVQIRGEIHS NVDYTVDLLN ASDFRENKIH TGWLDTRIAM RVQAERPPWY ISVVGGALYK
TVTANTATVS DYVGYLTKGQ IPPKHISLVY TTVALNIDGK KYTIETVRSG HGSYRLRMNG
SMVEANVQTL CDGGLLMQLD GNSHVIYAEE EASGTRLLID GKTCMLQNDH DPSKLLAETP
CKLLRFLVAD GAHVDADVPY AEVEVMKMCM PLLSPASGVI HVVMSEGQAM QAGDLIARLD
LDDPSAVKRA EPFDDTFPQM GLPIAASGQV HKLCASSLNA CRMILAGYEH DIDKVVPELV
YCLDTPELPF LQWEELMSVL ATRLPRNLKS ELEGKYEECK VKFDSGIIND FPAKMLGVTI
EENLACGSEK EKATNERLVE PLMSLLKSYE GGRESHAHFV VKSLFEEYLY VEELFSDGIQ
SDVIERLRLQ HSKDLQKVVD IVLSHQSVRN KTKLILKLME SLVYPNPAAY RDQLIRFSSL
NHKAYYKLAL KASELLEQTK LSELRARIAR SLSELEMFTE ESKGLSMHQR EIAIKESMED
LVTAPLPVED ALISLFDCSD TTVQQRVIET YIARLYQPHL VKDSIKMKWI ESGVIALWEC
PEGHFDARNG GAVLGDKRWG AMVIVKSLES LSMAIRFALK ETSHYTSSEG NMMHIALFGA
DNKMNIIQES GDDADRIAKL PLILKDNVTD LHASGVKTIS FIVQRDEARM TMRRTFLWSD
DKLSYEEEPI LRHVEPPLSA LLELDKLKVK GYNEMKYTPS RDRQWHIYTL RNTENPKMLH
RVFFRTLVRQ PSVSNKFSSG QIGDMEVGSA EEPLSFTSTS ILRSLMTAIE ELELHAIRTG
HSHMYLHVLK EQKLLDLVPV SGNIVLDVGQ DEATAYSLLK EMAMKIHELV GARMHHLSVC
QWEVKLKLDC DGPAGGTWRI VTTNVTSHTC TVDIYREVED TEARKLVYHS ASPAAGPLHG
VALNNPYQPL SVIDLKRCSA RNNRTTYCYD FPLAFETAVR KSWSSSTSGA SKGVENAQCY
VKATELVFAD KHGSWGTPLA QMDRPAGLND IGMVAWTLKM STPEFPSGRE IIVVANDITF
RAGSFGPRED AFFEAVTNLA CEKKLPLIYL AANSGARIGI ADEVKSCFRV GWSDDGSPER
GFQYIYLSEE DYARIGTSVI AHKMQLDSGE IRWVIDSVVG KEDGLGVENI HGSAAIASAY
SRAYKETFTL TFVTGRTVGI GAYLARLGIR CIQRLDQPII LTGYSALNKL LGREVYSSHM
QLGGPKIMAT NGVVHLTVSD DLEGVSNILR WLSYVPAYIG GPLPVTTPLD PPDRPVAYIP
ENSCDPRAAI RGVDDSQGKW LGGMFDKDSF VETFEGWAKT VVTGRAKLGG IPVGVIAVET
QTMMQTIPAD PGQLDSREQS VPRAGQVWFP DSATKTAQAL LDFNREGLPL FILANWRGFS
GGQRDLFEGI LQAGSTIVEN LRTYNQPAFV YIPMAAELRG GAWVVVDSKI NPDRIECYAE
RTAKGNVLEP QGLIEIKFRS EELQDCMGRL DPTLIDLKAK LEAANKNGSA DTKSLQENIE
ARTKQLMPLY TQIAIRFAEL HDTSLRMAAK GVIKKVVDWG ESRSFFYKRL RRRISEDVLA
KEIRAVAGEQ FSHQPAIELI KKWYSASHAA EWDDDDAFVA WMDNPENYKD YIQDLKAQRV
SQSLSSLSDS SSDLQALPQG LSMLLDKMDP SRRAQLVEEI RKVLG
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