ID   A0A0E0R421_ORYRU        Unreviewed;       894 AA.
AC   A0A0E0R421;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=2-isopropylmalate synthase LeuA allosteric (dimerisation) domain-containing protein {ECO:0000259|SMART:SM00917};
OS   Oryza rufipogon (Brownbeard rice) (Asian wild rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX   NCBI_TaxID=4529 {ECO:0000313|EnsemblPlants:ORUFI11G02570.4, ECO:0000313|Proteomes:UP000008022};
RN   [1] {ECO:0000313|Proteomes:UP000008022}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=cv. W1943 {ECO:0000313|Proteomes:UP000008022};
RA   Zhao Q.;
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblPlants:ORUFI11G02570.4}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000256|ARBA:ARBA00004116}.
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DR   AlphaFoldDB; A0A0E0R421; -.
DR   EnsemblPlants; ORUFI11G02570.4; ORUFI11G02570.4; ORUFI11G02570.
DR   Gramene; ORUFI11G02570.4; ORUFI11G02570.4; ORUFI11G02570.
DR   Proteomes; UP000008022; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005773; C:vacuole; IEA:UniProtKB-SubCell.
DR   GO; GO:0003852; F:2-isopropylmalate synthase activity; IEA:InterPro.
DR   GO; GO:0016844; F:strictosidine synthase activity; IEA:InterPro.
DR   GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.238.260; -; 1.
DR   Gene3D; 3.30.160.270; -; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR   InterPro; IPR013709; 2-isopropylmalate_synth_dimer.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR036230; LeuA_allosteric_dom_sf.
DR   InterPro; IPR000891; PYR_CT.
DR   InterPro; IPR018119; Strictosidine_synth_cons-reg.
DR   PANTHER; PTHR10277:SF9; 2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED; 1.
DR   PANTHER; PTHR10277; HOMOCITRATE SYNTHASE-RELATED; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   Pfam; PF08502; LeuA_dimer; 1.
DR   Pfam; PF20067; SSL_N; 2.
DR   Pfam; PF03088; Str_synth; 1.
DR   SMART; SM00917; LeuA_dimer; 1.
DR   SUPFAM; SSF110921; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR   SUPFAM; SSF101898; NHL repeat; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00022430};
KW   Leucine biosynthesis {ECO:0000256|ARBA:ARBA00022430};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008022};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        53..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        145..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          728..872
FT                   /note="2-isopropylmalate synthase LeuA allosteric
FT                   (dimerisation)"
FT                   /evidence="ECO:0000259|SMART:SM00917"
SQ   SEQUENCE   894 AA;  97234 MW;  E6E2A17F5FDCF3BD CRC64;
     MSRSKCDKAI NHISTLHKQI RSRSRVAISL IAVTISLIAV IHIGSGLLVP MKASLVVLAA
     AVAAAAALLV SLDPRSDDVP VLEIRERDVE LITVDAGGAV GPESVAFDGD GEGPYTGVSD
     GRVLKWLPLE RRWVEHSSAV IEPQLLAYLA TMNTTAKLLA LAVFAAAAIL SLDSRSDVRQ
     LEIRDGDVEL IPLLDGAAGP ESIVFGDAGD GPYTSVSDGR ILKWLPPPER RWVEHSCSVP
     ELLDSCRGSK DTKREQECGR PLGLKFNSKT GELYVADAYL GLRVVSPGEN VSRPLVPKRT
     GSPFSFSNGV EIDHETGVIY FTETSTRFQR REFLNIVITG DNTGRLLKYD PKENKVEVLV
     DGLRFPNGLA MSIDGSYLLL AETTTGKILR YWIKTPKAST IEEVAQLPGF PDNIKMSPRG
     GFWVGLHAKR GKIAEWSISY PWLRKLILKL PAQRIQRITS FLTGFGRQVI ALRLSEDGKT
     IEAMSVHGDV RKLFKSISEV EEKDGNLWIG SVLSNREFLY HILEEVIKAG ATTLNIPDTV
     GYTLPYEFGK LIADIKANTP GIENAIISTH CQNDLGARQL EVTINGIGER AGNASLEEVV
     MAIKCRRELL GGLYTGINTQ HITMSSKMVQ EHSGLHVQPH KAIVGANAFA HESGIHQDGM
     LKYKGTYEII SPDDIGLTRA NEFGIVLGKL SGRHAVRSKL VELGYEITDK EFEDFFKRYK
     EVAEKKKRVT DEDIEALLSD EIFQPKVFWS LADVQATCGT LGLSTATVKL IGPDGEEKIA
     CAVGTGPVDA AYKAVDDIIQ IPTVLREYSM TSVTEGIDAI ATTRVVVTGD VSDSKHALTG
     HSFSRAFSGS GAALDIVVSS VRAYLSALNK MSSFVGAIKA SSEVSESQRV QTTE
//