ID A0A0E1RXD3_COCIM Unreviewed; 825 AA.
AC A0A0E1RXD3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Sulfate permease {ECO:0000313|EMBL:EAS33867.1};
GN ORFNames=CIMG_04891 {ECO:0000313|EMBL:EAS33867.1};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS33867.1, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG704914; EAS33867.1; -; Genomic_DNA.
DR RefSeq; XP_001245450.1; XM_001245449.2.
DR AlphaFoldDB; A0A0E1RXD3; -.
DR STRING; 246410.A0A0E1RXD3; -.
DR GeneID; 4563514; -.
DR KEGG; cim:CIMG_04891; -.
DR VEuPathDB; FungiDB:CIMG_04891; -.
DR InParanoid; A0A0E1RXD3; -.
DR OMA; TRGESMF; -.
DR OrthoDB; 1082533at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF55; SODIUM-INDEPENDENT SULFATE ANION TRANSPORTER; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 87..105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 117..136
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 142..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 197..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 254..278
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 284..309
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 410..429
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 491..508
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 573..698
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 605..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 89613 MW; 133B479C62EF6A18 CRC64;
MASQPSTNAQ KVGHGLAKVL GIKLEKPDAD PVTRGESTFS TGSGDTFVEH EPSSIDWLAE
CVPSGRQVLM FIVNIFPFLR WLTRYNVQWF LGDLVAGVTV GAVVVPQGMA YAKLAELPVE
FGLYSSFMGV LVYWFFATSK DITIGPVAVV STLVGHIIVR VRMEHPEFEP HVIASAFGVI
CGAVVTFVGL IRCGWLVDFI PLTAISAFMT GSALSISSGQ VPSMLGITTF NTRDSTYKLI
INTLKHLGDT KIDAAMGLSA LFILYAVRSG CTYCARKYPS RAKLWFFLAT LRTVIVILFY
TGVSAGVNIH RRDNPRFRIL GTVPRGFQHA AVPDLNPGLL SAFSGDIPAG VIVLLIEHIA
ISKSFGRINN YTIDPSQELI GIGVTNLLGP FLGGYPATGS FSRTAIQSKA GVRTPFGGVI
TAMVVLLAIY ALPPVFFYIP NSSLSAVIIH AVGDLITPPN TVYQFWRVSP LEVVVFFAGV
FVMVFTNIEN GIYTTVCMSL AILLFRLVKA QGQFLGRVKV HTVVGDHLAD SDGKYNGWGA
ETGPRSSAFR NIFLPISHAD GSNPEIEVGQ PYPGVFIYRF SEGFNYPSVN HYLDHLVSTI
YKNTRRTNPN SYSRPGDRPW NMPGPRRGQS EEDRSHLPTL KAVILDFSTV NNVDVTSVQN
LIDVRNQLDL YASPQPVHWH FAHLNNRWTK RALASAGFGF HTPTANSGAT RWKPIFSVAN
LEGNASAAAH AEFLDNEREN GHAVSSKHDI ESPATDSATS TIQRAGGVIG AKNSSSVSVI
EKELVTATEY AKHRMTVVNG VNRPLFHADL TSALQSAIAN AASMT
//
