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Database: UniProt
Entry: A0A0E3NTN6_9EURY
LinkDB: A0A0E3NTN6_9EURY
Original site: A0A0E3NTN6_9EURY 
ID   A0A0E3NTN6_9EURY        Unreviewed;       217 AA.
AC   A0A0E3NTN6;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=Putative thymidylate synthase {ECO:0000256|HAMAP-Rule:MF_01686};
DE            Short=TS {ECO:0000256|HAMAP-Rule:MF_01686};
DE            Short=TSase {ECO:0000256|HAMAP-Rule:MF_01686};
DE            EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_01686};
GN   Name=thyA {ECO:0000256|HAMAP-Rule:MF_01686};
GN   ORFNames=MSMTP_0103 {ECO:0000313|EMBL:AKB23572.1};
OS   Methanosarcina sp. MTP4.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=1434100 {ECO:0000313|EMBL:AKB23572.1, ECO:0000313|Proteomes:UP000033049};
RN   [1] {ECO:0000313|EMBL:AKB23572.1, ECO:0000313|Proteomes:UP000033049}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MTP4 {ECO:0000313|EMBL:AKB23572.1,
RC   ECO:0000313|Proteomes:UP000033049};
RA   Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA   Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT   "Methanogenic archaea and the global carbon cycle.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May catalyze the biosynthesis of dTMP using an unknown
CC       cosubstrate. {ECO:0000256|HAMAP-Rule:MF_01686}.
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis. {ECO:0000256|HAMAP-
CC       Rule:MF_01686}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_01686}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01686}.
CC   -!- SIMILARITY: Belongs to the thymidylate synthase family. Archaeal-type
CC       ThyA subfamily. {ECO:0000256|HAMAP-Rule:MF_01686}.
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DR   EMBL; CP009505; AKB23572.1; -; Genomic_DNA.
DR   RefSeq; WP_048177095.1; NZ_CP009505.1.
DR   AlphaFoldDB; A0A0E3NTN6; -.
DR   STRING; 1434100.MSMTP_0103; -.
DR   GeneID; 24855296; -.
DR   KEGG; metm:MSMTP_0103; -.
DR   PATRIC; fig|1434100.4.peg.134; -.
DR   HOGENOM; CLU_084975_0_0_2; -.
DR   OrthoDB; 50118at2157; -.
DR   UniPathway; UPA00575; -.
DR   Proteomes; UP000033049; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR   Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR   HAMAP; MF_01686; Thymidy_synth_arch; 1.
DR   InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR   InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR   InterPro; IPR014620; Thymidylate_synthase_arc.
DR   NCBIfam; TIGR03283; thy_syn_methano; 1.
DR   PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR   PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE 1; 1.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PIRSF; PIRSF036752; TSase_MJ051; 1.
DR   SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01686};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW   Rule:MF_01686}; Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_01686};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033049};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_01686}.
FT   DOMAIN          66..213
FT                   /note="Thymidylate synthase/dCMP hydroxymethylase"
FT                   /evidence="ECO:0000259|Pfam:PF00303"
FT   ACT_SITE        139
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01686"
SQ   SEQUENCE   217 AA;  25113 MW;  9A5BFCD45A5FAE21 CRC64;
     MEEKLEIGRI IRAKNISDAW YRGLNIIWNH GQVITDERGS QIREFMDLMV VIEDPYTNRI
     PADTAWNEER LEEYAKQLIS GENVQDFEYT YGQRLRNWNE EVDQIEYVIE KLKESPTSRR
     ATAVTWIPPV DTKVNEVPCM MLDDFKIRDG KVHLTTLFRS HDFGGAYPAN LYGLSKLLEY
     VAGRIGVEPG KITTVSISAH VYDHDWDMVE NIVKGVC
//
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