ID A0A0E3NTN6_9EURY Unreviewed; 217 AA.
AC A0A0E3NTN6;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Putative thymidylate synthase {ECO:0000256|HAMAP-Rule:MF_01686};
DE Short=TS {ECO:0000256|HAMAP-Rule:MF_01686};
DE Short=TSase {ECO:0000256|HAMAP-Rule:MF_01686};
DE EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_01686};
GN Name=thyA {ECO:0000256|HAMAP-Rule:MF_01686};
GN ORFNames=MSMTP_0103 {ECO:0000313|EMBL:AKB23572.1};
OS Methanosarcina sp. MTP4.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434100 {ECO:0000313|EMBL:AKB23572.1, ECO:0000313|Proteomes:UP000033049};
RN [1] {ECO:0000313|EMBL:AKB23572.1, ECO:0000313|Proteomes:UP000033049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MTP4 {ECO:0000313|EMBL:AKB23572.1,
RC ECO:0000313|Proteomes:UP000033049};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May catalyze the biosynthesis of dTMP using an unknown
CC cosubstrate. {ECO:0000256|HAMAP-Rule:MF_01686}.
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis. {ECO:0000256|HAMAP-
CC Rule:MF_01686}.
CC -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_01686}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01686}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family. Archaeal-type
CC ThyA subfamily. {ECO:0000256|HAMAP-Rule:MF_01686}.
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DR EMBL; CP009505; AKB23572.1; -; Genomic_DNA.
DR RefSeq; WP_048177095.1; NZ_CP009505.1.
DR AlphaFoldDB; A0A0E3NTN6; -.
DR STRING; 1434100.MSMTP_0103; -.
DR GeneID; 24855296; -.
DR KEGG; metm:MSMTP_0103; -.
DR PATRIC; fig|1434100.4.peg.134; -.
DR HOGENOM; CLU_084975_0_0_2; -.
DR OrthoDB; 50118at2157; -.
DR UniPathway; UPA00575; -.
DR Proteomes; UP000033049; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_01686; Thymidy_synth_arch; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR014620; Thymidylate_synthase_arc.
DR NCBIfam; TIGR03283; thy_syn_methano; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PIRSF; PIRSF036752; TSase_MJ051; 1.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01686};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW Rule:MF_01686}; Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_01686};
KW Reference proteome {ECO:0000313|Proteomes:UP000033049};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_01686}.
FT DOMAIN 66..213
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 139
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01686"
SQ SEQUENCE 217 AA; 25113 MW; 9A5BFCD45A5FAE21 CRC64;
MEEKLEIGRI IRAKNISDAW YRGLNIIWNH GQVITDERGS QIREFMDLMV VIEDPYTNRI
PADTAWNEER LEEYAKQLIS GENVQDFEYT YGQRLRNWNE EVDQIEYVIE KLKESPTSRR
ATAVTWIPPV DTKVNEVPCM MLDDFKIRDG KVHLTTLFRS HDFGGAYPAN LYGLSKLLEY
VAGRIGVEPG KITTVSISAH VYDHDWDMVE NIVKGVC
//