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Database: UniProt
Entry: A0A0E3NU58_9EURY
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ID   A0A0E3NU58_9EURY        Unreviewed;       570 AA.
AC   A0A0E3NU58;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   25-OCT-2017, entry version 12.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   ORFNames=MSMTP_0100 {ECO:0000313|EMBL:AKB23569.1};
OS   Methanosarcina sp. MTP4.
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=1434100 {ECO:0000313|EMBL:AKB23569.1, ECO:0000313|Proteomes:UP000033049};
RN   [1] {ECO:0000313|EMBL:AKB23569.1, ECO:0000313|Proteomes:UP000033049}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MTP4 {ECO:0000313|EMBL:AKB23569.1,
RC   ECO:0000313|Proteomes:UP000033049};
RA   Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA   Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT   "Methanogenic archaea and the global carbon cycle.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
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DR   EMBL; CP009505; AKB23569.1; -; Genomic_DNA.
DR   RefSeq; WP_048177090.1; NZ_CP009505.1.
DR   EnsemblBacteria; AKB23569; AKB23569; MSMTP_0100.
DR   GeneID; 24855293; -.
DR   KEGG; metm:MSMTP_0100; -.
DR   PATRIC; fig|1434100.4.peg.130; -.
DR   KO; K00399; -.
DR   OrthoDB; POG093Z00ZI; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000033049; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000033049};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000033049};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000313|EMBL:AKB23569.1}.
FT   DOMAIN       16    282       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      330    461       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       161    161       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     271    271       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     285    285       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   570 AA;  61725 MW;  446A800727851A5F CRC64;
     MSADIFAKFK KSMEVKFAQD YGTNQLGGSD IEAKTSKFLR LGPEQSPRKV EMIAAGKEIA
     EKRGIVGYNP NMHMGAPLGQ RAITPYTLSG TDIVAEPDDL HYVNNAAMQQ MWDDIRRTCI
     VGLDMAHETL EKRLGKEVTP ETINHYLETL NHAMPGAAVV QEMMIETHPA LVDDCYVKIF
     TGDDALADEI DSQFVININK MFPEEQAEQI KASIGKTTWQ AIHIPTIVSR TTDGAQTSRW
     AAMQIGMSFI SAYAMCAGEA AVADLSFSAK HASLVSMGEM LPARRARGPN EPGGLSFGHM
     ADVIQTSRVD VDDPAHVSLE VVGAGCMLYD QIWLGSYMSG GVGFTQYATA AYTDDILDNN
     TYYDVDYIND KYGGAAAVDK PTVKASLEVV KDIATESTLY GIETYENYPT ALEDHFGGSQ
     RATMLAAASG VACSLATGNG NAGLSGWYLS MYVHKEAWGR LGFFGFDLQD QCGATNICTY
     QGDEGLPGEL RGPNYPNYAM NVGHQGGYGG IASAAHSTRG DAFAVNPLIK VCFADDLLPF
     DFTAPRREFG RGAIREFVPA GERSLIIPAK
//
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