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Database: UniProt
Entry: A0A0E3P281_9EURY
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ID   A0A0E3P281_9EURY        Unreviewed;       240 AA.
AC   A0A0E3P281;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit A {ECO:0000256|HAMAP-Rule:MF_01093};
DE            EC=2.1.1.86 {ECO:0000256|HAMAP-Rule:MF_01093};
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A {ECO:0000256|HAMAP-Rule:MF_01093};
GN   Name=mtrA {ECO:0000256|HAMAP-Rule:MF_01093};
GN   ORFNames=MSMTP_3021 {ECO:0000313|EMBL:AKB26490.1};
OS   Methanosarcina sp. MTP4.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=1434100 {ECO:0000313|EMBL:AKB26490.1, ECO:0000313|Proteomes:UP000033049};
RN   [1] {ECO:0000313|EMBL:AKB26490.1, ECO:0000313|Proteomes:UP000033049}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MTP4 {ECO:0000313|EMBL:AKB26490.1,
RC   ECO:0000313|Proteomes:UP000033049};
RA   Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA   Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT   "Methanogenic archaea and the global carbon cycle.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC       coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC       tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC       translocating step. {ECO:0000256|HAMAP-Rule:MF_01093}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01093};
CC   -!- COFACTOR:
CC       Name=5-hydroxybenzimidazolylcob(I)amide; Xref=ChEBI:CHEBI:60494;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01093};
CC       Note=Binds 1 5-hydroxybenzimidazolylcobamide group. {ECO:0000256|HAMAP-
CC       Rule:MF_01093};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       2/2. {ECO:0000256|HAMAP-Rule:MF_01093}.
CC   -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC       MtrE, MtrF, MtrG and MtrH. {ECO:0000256|HAMAP-Rule:MF_01093}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01093};
CC       Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01093}.
CC   -!- SIMILARITY: Belongs to the MtrA family. {ECO:0000256|HAMAP-
CC       Rule:MF_01093}.
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DR   EMBL; CP009505; AKB26490.1; -; Genomic_DNA.
DR   RefSeq; WP_048181750.1; NZ_CP009505.1.
DR   AlphaFoldDB; A0A0E3P281; -.
DR   STRING; 1434100.MSMTP_3021; -.
DR   GeneID; 24858484; -.
DR   KEGG; metm:MSMTP_3021; -.
DR   PATRIC; fig|1434100.4.peg.4032; -.
DR   HOGENOM; CLU_100863_0_0_2; -.
DR   OrthoDB; 130682at2157; -.
DR   UniPathway; UPA00640; UER00698.
DR   Proteomes; UP000033049; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050897; F:cobalt ion binding; IEA:InterPro.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   HAMAP; MF_01093; MtrA; 1.
DR   InterPro; IPR030688; MeTrfase_MtrA/MtxA.
DR   InterPro; IPR005778; MtrA.
DR   NCBIfam; TIGR01111; mtrA; 1.
DR   Pfam; PF04208; MtrA; 1.
DR   PIRSF; PIRSF500207; MtrA; 1.
DR   PIRSF; PIRSF009452; MtrA_MtxA; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01093};
KW   Cobalt {ECO:0000256|ARBA:ARBA00023285, ECO:0000256|HAMAP-Rule:MF_01093};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01093};
KW   Methanogenesis {ECO:0000256|HAMAP-Rule:MF_01093};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW   Rule:MF_01093}; One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_01093};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033049};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_01093, ECO:0000313|EMBL:AKB26490.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01093};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01093}.
FT   TRANSMEM        221..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01093"
FT   BINDING         85
FT                   /ligand="5-hydroxybenzimidazolylcob(I)amide"
FT                   /ligand_id="ChEBI:CHEBI:60494"
FT                   /ligand_note="cofactor"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01093"
SQ   SEQUENCE   240 AA;  25308 MW;  07ABC55AAE3EA977 CRC64;
     MVDKRDPAPG WPILKGEYEV GDVQGCVAVI TCASHLPGKP VLDAGAAITG SCKTENLGIE
     KVVAHVISNP NIRYLVVTGA EVKGHITGQA ALSLHENGVK ENRIVGAIGA IPYVENLNPE
     AVERFQAQVE TVELLNTEDM GVITAKVKEL VSKDPGAFDA EPLVVEISEE GEGEEDVGVV
     RPVSGEIATI RSRLKGIEAR MLDIGNLNKF HSGIHAGKVE GAMIGLTVTI SLLGLLLLGR
//
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