ID A0A0E3SR18_METMT Unreviewed; 312 AA.
AC A0A0E3SR18;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Bifunctional protein: zinc-containing alcohol dehydrogenase {ECO:0000313|EMBL:AKB85236.1};
DE EC=1.1.1.- {ECO:0000313|EMBL:AKB85236.1};
GN ORFNames=MCMEM_1183 {ECO:0000313|EMBL:AKB85236.1};
OS Methanococcoides methylutens MM1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanococcoides.
OX NCBI_TaxID=1434104 {ECO:0000313|EMBL:AKB85236.1, ECO:0000313|Proteomes:UP000033048};
RN [1] {ECO:0000313|EMBL:AKB85236.1, ECO:0000313|Proteomes:UP000033048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MM1 {ECO:0000313|EMBL:AKB85236.1,
RC ECO:0000313|Proteomes:UP000033048};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. Quinone oxidoreductase subfamily.
CC {ECO:0000256|ARBA:ARBA00010371}.
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DR EMBL; CP009518; AKB85236.1; -; Genomic_DNA.
DR RefSeq; WP_048205358.1; NZ_CP009518.1.
DR AlphaFoldDB; A0A0E3SR18; -.
DR STRING; 1434104.MCMEM_1183; -.
DR GeneID; 24893724; -.
DR KEGG; mmet:MCMEM_1183; -.
DR PATRIC; fig|1434104.5.peg.1296; -.
DR HOGENOM; CLU_026673_3_3_2; -.
DR OrthoDB; 146629at2157; -.
DR Proteomes; UP000033048; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd08267; MDR1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR11695; ALCOHOL DEHYDROGENASE RELATED; 1.
DR PANTHER; PTHR11695:SF294; RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:AKB85236.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033048}.
FT DOMAIN 10..303
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 312 AA; 33957 MW; DEEFBB3D3F27398C CRC64;
MKAFVYYKYG SFDVLQLTEV DKPIPKDSEV LIKIHATTVT IGDTIMRSFK LPTPRWQWIP
ARLYLGIRGP KRPVLGMELA GEIEAVGTDV TRFSVGDQVF ASTFRENFGG HAEYKCMPED
GLLILKPENL TYEEAAAVPG GGMTALQLLK KGNVRSGQKV LINGASGAVG TNAVQLAKHF
GAEVTGVCST SNMDLVKSLG ADKVIDYTKE DFTKSEETYD MVLDAVGKIP SSKAKSVLKK
GGNYLNVLAS ADDGDTIENL TFLKELIESG DLKPVIDRIY PFEQIPEAHK YVEQGHKKGN
VAIAVDHGNN AD
//
