ID A0A0E3YSK5_9BACT Unreviewed; 492 AA.
AC A0A0E3YSK5;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=glutamate synthase (NADPH) {ECO:0000256|ARBA:ARBA00012079};
DE EC=1.4.1.13 {ECO:0000256|ARBA:ARBA00012079};
GN ORFNames=IMCC26134_00200 {ECO:0000313|EMBL:AKC81584.1};
OS Verrucomicrobia bacterium IMCC26134.
OC Bacteria; Verrucomicrobiota.
OX NCBI_TaxID=1637999 {ECO:0000313|EMBL:AKC81584.1, ECO:0000313|Proteomes:UP000033046};
RN [1] {ECO:0000313|EMBL:AKC81584.1, ECO:0000313|Proteomes:UP000033046}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IMCC26134 {ECO:0000313|EMBL:AKC81584.1,
RC ECO:0000313|Proteomes:UP000033046};
RA Choi A., Kang I., Cho J.-C.;
RT "Complete genome sequence of Verrucomicrobia strain IMCC26134.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine
CC + NADPH; Xref=Rhea:RHEA:15501, ChEBI:CHEBI:15378, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:58359; EC=1.4.1.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001895};
CC -!- PATHWAY: Amino-acid biosynthesis; L-glutamate biosynthesis via GLT
CC pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+)
CC route): step 1/1. {ECO:0000256|ARBA:ARBA00037898}.
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DR EMBL; CP011265; AKC81584.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0E3YSK5; -.
DR STRING; 1637999.IMCC26134_00200; -.
DR KEGG; vba:IMCC26134_00200; -.
DR PATRIC; fig|1637999.3.peg.41; -.
DR HOGENOM; CLU_000422_3_1_0; -.
DR OrthoDB; 9803192at2; -.
DR Proteomes; UP000033046; Chromosome.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0016639; F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006537; P:glutamate biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 3.
DR InterPro; IPR028261; DPD_II.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR006005; Glut_synth_ssu1.
DR InterPro; IPR009051; Helical_ferredxn.
DR NCBIfam; TIGR01317; GOGAT_sm_gam; 1.
DR PANTHER; PTHR43100; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR PANTHER; PTHR43100:SF1; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR Pfam; PF14691; Fer4_20; 1.
DR Pfam; PF07992; Pyr_redox_2; 2.
DR PRINTS; PR00419; ADXRDTASE.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF51971; Nucleotide-binding domain; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Glutamate biosynthesis {ECO:0000256|ARBA:ARBA00023164};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000033046}.
FT DOMAIN 24..140
FT /note="Dihydroprymidine dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF14691"
FT DOMAIN 153..329
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
FT DOMAIN 403..474
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
SQ SEQUENCE 492 AA; 53857 MW; 05E12A2C1E722D21 CRC64;
MGKPTGFLEY LREIPADRPP LERVRDYKEF HLHMEEKHLR NQGARCMDCG VPFCHTGKLI
SGMAAGCPIN NLIPEFNDLV YRGRWQEALE RLHKTNNFPE FTGRVCPAPC EGSCVLGINN
PPVTIKNIEY SIIEKGWEEG WVLPNTPRSR TGKKVAVIGS GPAGLSAASQ LNAAGHTVTV
YERADRPGGL LMYGIPNMKL DKNEVVLRRI RLMEEEGIKF VYNANIGVSH DAAQLRKDHD
AIVIATGATL PRDLPIEGRS HAGVHFAMEF LTANTKAVLD GTAPAISAKD KDVIVIGGGD
TGTDCVGTSL RHGCKSITQI EILPKPALER TPDNPWPEWP KVYKLDYGQE EAAARYGADP
RVYLTTVKKF TASASGPVES LVTVEIKWGK NEKGQFVPQE LPGTEKTRPA QLVLLAMGFL
GPEQALVKAL TLDTDPRSNI KADHNVHTTN LPGVFAAGDC RRGQSLVVWA INEGRAAARE
CDRYLMGSTT LP
//