ID A0A0E7Z6D0_MYCTX Unreviewed; 150 AA.
AC A0A0E7Z6D0;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Methyltransferase {ECO:0000313|EMBL:CKR93410.1, ECO:0000313|EMBL:SGI19203.1};
DE EC=2.1.1.182 {ECO:0000313|EMBL:CKR93410.1, ECO:0000313|EMBL:SGI19203.1};
DE SubName: Full=rRNA adenine N-6-methyltransferase {ECO:0000313|EMBL:OMH59923.1};
DE EC=2.1.1.- {ECO:0000313|EMBL:CKR93410.1, ECO:0000313|EMBL:OMH59923.1};
GN Name=rsmA_1 {ECO:0000313|EMBL:CKR93410.1};
GN Synonyms=ermD {ECO:0000313|EMBL:OMH59923.1}, rsmA
GN {ECO:0000313|EMBL:COW20061.1}, rsmA_2 {ECO:0000313|EMBL:CFH94691.1};
GN ORFNames=A4S10_02094 {ECO:0000313|EMBL:OMH59923.1}, ERS007722_02015
GN {ECO:0000313|EMBL:COW20061.1}, ERS007741_00098
GN {ECO:0000313|EMBL:COV52657.1}, ERS023442_02067
GN {ECO:0000313|EMBL:CNM52173.1}, ERS027646_00965
GN {ECO:0000313|EMBL:CKR93410.1}, ERS053720_03495
GN {ECO:0000313|EMBL:CFH94691.1}, SAMEA2683035_03034
GN {ECO:0000313|EMBL:SGI19203.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:CKR93410.1, ECO:0000313|Proteomes:UP000048948};
RN [1] {ECO:0000313|Proteomes:UP000045030, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH94691.1,
RC ECO:0000313|Proteomes:UP000046674}, and A70144_1
RC {ECO:0000313|EMBL:CNM52173.1, ECO:0000313|Proteomes:UP000045030};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000043293, ECO:0000313|Proteomes:UP000048600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGI19203.1,
RC ECO:0000313|Proteomes:UP000182946}, Bir 172
RC {ECO:0000313|EMBL:CKR93410.1, ECO:0000313|Proteomes:UP000048948},
RC M09502139 {ECO:0000313|EMBL:COW20061.1,
RC ECO:0000313|Proteomes:UP000043293}, and P00601463
RC {ECO:0000313|EMBL:COV52657.1, ECO:0000313|Proteomes:UP000048600};
RG Pathogen Informatics;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:OMH59923.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH59923.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OMH59923.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH59923.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. rRNA adenine N(6)-methyltransferase family.
CC {ECO:0000256|PROSITE-ProRule:PRU01026}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01026}.
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DR EMBL; CFSW01000027; CFH94691.1; -; Genomic_DNA.
DR EMBL; CNGE01000120; CKR93410.1; -; Genomic_DNA.
DR EMBL; CQFV01000030; CNM52173.1; -; Genomic_DNA.
DR EMBL; CHKL01000004; COV52657.1; -; Genomic_DNA.
DR EMBL; CSAM01000132; COW20061.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH59923.1; -; Genomic_DNA.
DR EMBL; FPTZ01000024; SGI19203.1; -; Genomic_DNA.
DR PATRIC; fig|1773.211.peg.462; -.
DR Proteomes; UP000043293; Unassembled WGS sequence.
DR Proteomes; UP000045030; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000048600; Unassembled WGS sequence.
DR Proteomes; UP000048948; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR GO; GO:0052908; F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001737; KsgA/Erm.
DR InterPro; IPR020598; rRNA_Ade_methylase_Trfase_N.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11727; DIMETHYLADENOSINE TRANSFERASE; 1.
DR PANTHER; PTHR11727:SF7; DIMETHYLADENOSINE TRANSFERASE-RELATED; 1.
DR Pfam; PF00398; RrnaAD; 1.
DR SMART; SM00650; rADc; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51689; SAM_RNA_A_N6_MT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01026}; RNA-binding {ECO:0000256|PROSITE-ProRule:PRU01026};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01026};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01026}.
FT DOMAIN 2..143
FT /note="Ribosomal RNA adenine methylase transferase N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00650"
FT BINDING 1
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 11
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 32
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 54
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 70
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01026"
SQ SEQUENCE 150 AA; 16351 MW; 487C0A51E07457DD CRC64;
MRPGELVFDI GAGEGALTAH LVRAGARVVA VELHPRRVGV LRERFPGITV VHADAASIRL
PGRPFRVVAN PPYGISSRLL RTLLAPNSGL VAADLVLQRA LVCKFASRNA RRFTLTVGLM
LPRRAFLPPP HVDSAVLVVR RRKCGDWQGR
//