ID A0A0E8B7A6_MYCTX Unreviewed; 452 AA.
AC A0A0E8B7A6;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Dehydrogenase {ECO:0000313|EMBL:OMH58589.1, ECO:0000313|EMBL:SGH98043.1};
DE EC=1.-.-.- {ECO:0000313|EMBL:SGH98043.1};
DE EC=1.1.99.1 {ECO:0000313|EMBL:OMH58589.1, ECO:0000313|EMBL:SGH98043.1};
GN Name=betA {ECO:0000313|EMBL:SGH98043.1};
GN Synonyms=betA_1 {ECO:0000313|EMBL:CFE39659.1};
GN ORFNames=A4S10_00742 {ECO:0000313|EMBL:OMH58589.1}, ERS007679_01247
GN {ECO:0000313|EMBL:COV18194.1}, ERS007681_02045
GN {ECO:0000313|EMBL:CFE39659.1}, ERS007688_00749
GN {ECO:0000313|EMBL:CFE47457.1}, ERS007703_00891
GN {ECO:0000313|EMBL:COV23254.1}, ERS027659_01172
GN {ECO:0000313|EMBL:CKR33502.1}, ERS053720_00200
GN {ECO:0000313|EMBL:CFH68339.1}, SAMEA2683035_02492
GN {ECO:0000313|EMBL:SGH98043.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:SGH98043.1, ECO:0000313|Proteomes:UP000182946};
RN [1] {ECO:0000313|EMBL:COV23254.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K00500041 {ECO:0000313|EMBL:COV23254.1};
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CFH68339.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH68339.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:OMH58589.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH58589.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:SGH98043.1, ECO:0000313|Proteomes:UP000182946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH98043.1,
RC ECO:0000313|Proteomes:UP000182946}, Bir 185
RC {ECO:0000313|EMBL:CKR33502.1, ECO:0000313|Proteomes:UP000050164},
RC G09801536 {ECO:0000313|EMBL:COV18194.1,
RC ECO:0000313|Proteomes:UP000045842}, G09901357
RC {ECO:0000313|EMBL:CFE39659.1, ECO:0000313|Proteomes:UP000048289},
RC H09601792 {ECO:0000313|EMBL:CFE47457.1,
RC ECO:0000313|Proteomes:UP000046947}, and K00500041
RC {ECO:0000313|Proteomes:UP000038802};
RG Pathogen Informatics;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:OMH58589.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH58589.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; CFOE01000243; CFE39659.1; -; Genomic_DNA.
DR EMBL; CFOH01000077; CFE47457.1; -; Genomic_DNA.
DR EMBL; CFSW01000001; CFH68339.1; -; Genomic_DNA.
DR EMBL; CNFT01000199; CKR33502.1; -; Genomic_DNA.
DR EMBL; CSAD01000127; COV18194.1; -; Genomic_DNA.
DR EMBL; CSAE01000063; COV23254.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH58589.1; -; Genomic_DNA.
DR EMBL; FPTZ01000017; SGH98043.1; -; Genomic_DNA.
DR STRING; 115862.BBG46_03780; -.
DR PATRIC; fig|1773.211.peg.970; -.
DR Proteomes; UP000038802; Unassembled WGS sequence.
DR Proteomes; UP000045842; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000046947; Unassembled WGS sequence.
DR Proteomes; UP000048289; Unassembled WGS sequence.
DR Proteomes; UP000050164; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR Gene3D; 3.30.410.40; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023978; GMC_oxidoreductase_bact.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR NCBIfam; TIGR03970; Rv0697; 1.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 3.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000313|EMBL:SGH98043.1}.
FT DOMAIN 57..271
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 331..447
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT BINDING 425
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 452 AA; 47669 MW; 81E5CAF7F4FE1C8F CRC64;
MDSSCVVTVL EAGPGLADPG LLAQTANGLQ LPIGAGSPLV ERYRTRLTDR PVRHLPIVRG
ATVGGSGAIN GGYFCRGLPS DFDRASIPGW AWSDVLEHFR AIETDLDFET PVHGRSGPIP
VRRTHEMTGI TESFMAAAED AGFAWIADLN DVGPEMPSGV GAVPLNIVNG VRTSSAVGYL
MPALGRPNLT LLARTRAVRL RFSATTAVGV DAIGPGGPVS LSADRIVLCA GAIQSAHLLM
LSGVGEEEVL RSAGVKVLMA LPVGMGCSDH PEWVMPTNWA VAVDRPVLEV LLSTHDGIEI
RPYTGGFVAM TGDGTAGHRD WPHIGVALMQ PRARGRITLV SSDPQIPVRI EHRYDSEPAD
VAALRQGSAL AHELCGAATR IGPAVWATSQ HLCGSAPMGT DDDPRAVVDP RCRVRGIENL
WVIDGSVLPS ITSRGPHATI VMLGHRAAEF VQ
//