ID A0A0E8UAB1_MYCTX Unreviewed; 340 AA.
AC A0A0E8UAB1;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=HTH-type transcriptional repressor PurR {ECO:0000313|EMBL:OMH61553.1};
DE SubName: Full=LacI family transcriptional regulator {ECO:0000313|EMBL:CFH88290.1};
GN Name=purR {ECO:0000313|EMBL:OMH61553.1};
GN ORFNames=A4S10_03745 {ECO:0000313|EMBL:OMH61553.1}, ERS053720_02822
GN {ECO:0000313|EMBL:CFH88290.1}, SAMEA2683035_00674
GN {ECO:0000313|EMBL:SGH24989.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:OMH61553.1, ECO:0000313|Proteomes:UP000189452};
RN [1] {ECO:0000313|EMBL:CFH88290.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH88290.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OMH61553.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH61553.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SGH24989.1, ECO:0000313|Proteomes:UP000182946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGH24989.1,
RC ECO:0000313|Proteomes:UP000182946};
RG Pathogen Informatics;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OMH61553.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH61553.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CFSW01000018; CFH88290.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH61553.1; -; Genomic_DNA.
DR EMBL; FPTZ01000003; SGH24989.1; -; Genomic_DNA.
DR PATRIC; fig|1773.206.peg.3968; -.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06279; PBP1_LacI-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146:SF138; HTH-TYPE TRANSCRIPTIONAL REGULATOR KDGR; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..45
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
SQ SEQUENCE 340 AA; 36190 MW; E1A825D2CD1606DB CRC64;
MSRTTVSNAF NRPDQLSADL RERVLATAKR LGYAGPDPVA RSLRTRKAGA VGLVMAEPLT
YFFSDPAARD FVAGVAQSCE ELGQGLQLVS VGSSRSLADG TAAVLGAGVD GFVVYSVGDD
DPYLQVVLQR RLPVVVVDQP KDLSGVSRVG IDDRAAMREL AGYVLGLGHR ELGLLTMRLG
RDRRQDLVDA ERLRSPTFDV QRERIVGVWE AMTAAGVDPD SLTVVESYEH LPTSGGTAAK
VALQANPRLT ALMCTADILA LSAMDYLRAH GIYVPGQMTV TGFDGVPEAL SRGLTTVAQP
SLHKGHRAGE LLLKPPRSGL PVIEVLDTEL VRGRTAGPPA
//
