ID A0A0F0H0V6_9ACTN Unreviewed; 1010 AA.
AC A0A0F0H0V6;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:KJK47288.1};
GN ORFNames=UK14_21135 {ECO:0000313|EMBL:KJK47288.1};
OS Streptomyces sp. NRRL F-4428.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609137 {ECO:0000313|EMBL:KJK47288.1, ECO:0000313|Proteomes:UP000033569};
RN [1] {ECO:0000313|EMBL:KJK47288.1, ECO:0000313|Proteomes:UP000033569}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-4428 {ECO:0000313|EMBL:KJK47288.1,
RC ECO:0000313|Proteomes:UP000033569};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJK47288.1}.
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DR EMBL; JYJI01000179; KJK47288.1; -; Genomic_DNA.
DR RefSeq; WP_045323104.1; NZ_JYJI01000179.1.
DR AlphaFoldDB; A0A0F0H0V6; -.
DR PATRIC; fig|1609137.3.peg.4872; -.
DR OrthoDB; 9772207at2; -.
DR Proteomes; UP000033569; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR Gene3D; 2.60.40.2220; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000033569}.
FT DOMAIN 516..595
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1010 AA; 111735 MW; AD5C8B03F0CAC952 CRC64;
MHDDRSITEH RLRRVLHERI RPAVHSSPLP LTVERWDAPG EPVPVAEGLA APYEPCAPGD
TWGPAWGTTW FKVTGTVPAA WAGRTVEAVL DLGFDRMMPG FQCEGLVHRA DGTGIKALNP
YNDWVRVADR AEGGERIEWY VEAAANPVLV DHRATYEGDL RTSGDRPLYR LARMDLTLFE
TEVWELVQDL DVLYELMTQL DTGDARRYEI LRALGAALDA VDLSDVPGTA AAARAHLADV
LAAPANASAH RISAVGHAHI DSAWLWPLRE TVRKVARTVS NMVNLMDGHP DLVFAMSQAQ
QLDWIKTHRP ELFERVKKKV ADGQFVPVGG MWVESDTNMV GGEAMARQFL YGKKFFLDEF
GIDTHNVWLP DSFGYTAAMP QLVRLSGSRW FLTQKICWSQ VNDFPHHTFW WEGIDGSRVF
THFPPVDTYN SDLGGAQMAH AARNYREKGW GSRSLVPFGW GDGGGGPTRE HLARARRQRD
LEGSPRIEIE RPDAFFEKAR AEYEDAPVWA GELYLELHRG TYTSQAKTKQ GNRRSESLLR
EAELWAATAA VRVPGYAYPY EDLERIWKTV LLHQFHDILP GSSIAWVHRE ARETYGRVAQ
ELRDITLAAQ RALAGEGTEE LVFNCAPHAR RGIPAGGAGR PAQPPEPVTV EERHGGGHVL
ANGLLVVEID ARGLIVSVHD LRARREAVAP GRAANLLQIH PDFPNMWDAW DVDEFYRNNV
TDLDDLDGLD GLEVAESGPR SATVRVTRSF GRSRAVQQIT LRAGAKTLDI VTDVDWHETE
KFLKAAFPLD VKADRTASET QFGHVYRATH TNTSWEAAKF EICAHRWIHA EEPGWGVALL
NDSTYGHDVT RDVRPDGGQT TTVRLSLLRA PRYPDPETDQ GAHTLRFSLA PGAGIGDAVR
EGHALNLPER TVPGAGPVAP LLAVDSDAVV VEAVKLAEDR GGDVIVRLYE SRGGRATATL
TASFPITGAV ESDLLERPLA GSAVGVPTPA DTVPLTLRPF QIVTLRLRRP
//
