ID A0A0F0H2M1_9ACTN Unreviewed; 539 AA.
AC A0A0F0H2M1;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=FAD-linked oxidase {ECO:0000313|EMBL:KJK48517.1};
GN ORFNames=UK14_18120 {ECO:0000313|EMBL:KJK48517.1};
OS Streptomyces sp. NRRL F-4428.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609137 {ECO:0000313|EMBL:KJK48517.1, ECO:0000313|Proteomes:UP000033569};
RN [1] {ECO:0000313|EMBL:KJK48517.1, ECO:0000313|Proteomes:UP000033569}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-4428 {ECO:0000313|EMBL:KJK48517.1,
RC ECO:0000313|Proteomes:UP000033569};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR625650-3};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJK48517.1}.
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DR EMBL; JYJI01000141; KJK48517.1; -; Genomic_DNA.
DR RefSeq; WP_045322736.1; NZ_JYJI01000141.1.
DR AlphaFoldDB; A0A0F0H2M1; -.
DR PATRIC; fig|1609137.3.peg.4068; -.
DR OrthoDB; 9811557at2; -.
DR Proteomes; UP000033569; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProt.
DR GO; GO:0008609; F:alkylglycerone-phosphate synthase activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.300.330; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.3450; -; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR025650; Alkyl-DHAP_Synthase.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR46568; ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL; 1.
DR PANTHER; PTHR46568:SF1; ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR625650-3};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR625650-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000033569}.
FT DOMAIN 98..280
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT REGION 358..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 459
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-1"
FT BINDING 131..137
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-3"
FT BINDING 264..270
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-3"
FT BINDING 397
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-2"
FT SITE 315
FT /note="Important for enzyme activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR625650-4"
SQ SEQUENCE 539 AA; 56855 MW; DFD689329E89DAAA CRC64;
MPGTRPQPTP ATRTRSWWGW GWSDAHPGDA ECAAMGALVP GTLAHPLPVP RVRDLDIERP
AVQPPAGLAH LVSTAPEERA AHAMGKAYRD VVRALRGRPG RIPDLVARPT DEREVADLLD
WAGERQVAVV PYGGGSSVSG GVEYRGDAHD AVLSLDLTAM DRVLEVDAVG RAARIQAGAL
GPGLEDQLRP HGLTLRHFPQ SFEFSTLGGW LATRAGGHYA TGRTHIDDFV QSLRVVTPAG
TSASWRLPAS GAGPSPDRLF LGSEGALGVI TEAWVRLQER PAHKASASLA FTDFHAALEA
VRALAQSDLS PANCRLLDAG EAALSGASHD GSAVLVLGFE SADGPVTARL GQAVDLARSH
GGRHGGRHGD PGGTGGADDD AAVSAWRSAF LRMPYLRDGL ARMGAVAETF ETAATWDRIP
GLIEAVRTEV GEAALKASGH PAIVNCRLTH VYPDGAAPYF TVLAGGRPGD EVAFWDDLKA
VASDVLHRHR ATITHHHAVG RDHRPGYDRQ RPDPFALALR AAKGALDPRG ILNPGVLVD
//
