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Database: UniProt
Entry: A0A0F0HFY6_9ACTN
LinkDB: A0A0F0HFY6_9ACTN
Original site: A0A0F0HFY6_9ACTN 
ID   A0A0F0HFY6_9ACTN        Unreviewed;       587 AA.
AC   A0A0F0HFY6;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   25-OCT-2017, entry version 21.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KJK54569.1};
GN   ORFNames=UK14_00420 {ECO:0000313|EMBL:KJK54569.1};
OS   Streptomyces sp. NRRL F-4428.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1609137 {ECO:0000313|EMBL:KJK54569.1, ECO:0000313|Proteomes:UP000033569};
RN   [1] {ECO:0000313|EMBL:KJK54569.1, ECO:0000313|Proteomes:UP000033569}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-4428 {ECO:0000313|EMBL:KJK54569.1,
RC   ECO:0000313|Proteomes:UP000033569};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KJK54569.1}.
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DR   EMBL; JYJI01000002; KJK54569.1; -; Genomic_DNA.
DR   EnsemblBacteria; KJK54569; KJK54569; UK14_00420.
DR   PATRIC; fig|1609137.3.peg.87; -.
DR   Proteomes; UP000033569; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000033569};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033569}.
FT   DOMAIN      280    408       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      494    563       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     288    295       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   587 AA;  65153 MW;  81555449A6ED0671 CRC64;
     MLEKLLGEGQ PGIEPKDKQW VERCQPLALV ADTALLAVPN EWGKRVLEGR LAPLISDALS
     RECGRPIRIA ITVDDSAGEP APPAPPVQQA GGYEPYGGQR PGGGGPSDDQ LPTARPAYPD
     YQQQRPEPGA WPRGGQQDDY GWQQPRLGGF PERDPYASPQ PGYLQQAEPS GYEQQYDQGS
     FDQGSFDQQQ YEQSPYEQQQ SHQPHQSHQY EQQSYEQPTP RTAPGRPAAP PAPSGGSTSG
     PLEPTARLNP KYLFDTFVIG ASNRFAHAAA VAVAEAPAKA YNPLFIYGES GLGKTHLLHA
     IGHYARSLYP GTRVRYVSSE EFTNEFINSI RDGKGDAFRK RYREMDILLV DDIQFLASKE
     STQEEFFHTF NTLHNANKQI VLSSDRPPKQ LVTLEDRLRN RFEWGLITDV QPPELETRIA
     ILRKKAVQEQ LNAPPEVLEF IASRISRNIR ELEGALIRVT AFASLNRQPV DLGLTEDVLK
     NLIPGGEDSA PEITATDIMA ATADYFGLTV DDLCGSSRSR VLVTARQIAM YLCRELTDLS
     LPKIGAQFGG RDHTTVMHAD RKIRALMAER RSIYNQVTEL TNRIKNG
//
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