ID A0A0F0I2X4_ASPPU Unreviewed; 690 AA.
AC A0A0F0I2X4;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Propionyl-CoA synthetase PrpE {ECO:0000313|EMBL:KJK61516.1};
GN ORFNames=P875_00042221 {ECO:0000313|EMBL:KJK61516.1};
OS Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1403190 {ECO:0000313|EMBL:KJK61516.1, ECO:0000313|Proteomes:UP000033540};
RN [1] {ECO:0000313|EMBL:KJK61516.1, ECO:0000313|Proteomes:UP000033540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1
RC {ECO:0000313|Proteomes:UP000033540};
RA Yu J., Fedorova N., Yin Y., Losada L., Zafar N., Taujale R., Ehrlich K.C.,
RA Bhatnagar D., Cleveland T.E., Bennett J.W., Nierman W.C.;
RT "Draft genome sequence of Aspergillus parasiticus SU-1.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJK61516.1}.
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DR EMBL; JZEE01000674; KJK61516.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F0I2X4; -.
DR STRING; 1403190.A0A0F0I2X4; -.
DR Proteomes; UP000033540; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000033540};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 122..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..68
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 75..485
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 552..635
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 690 AA; 75670 MW; 37282818A41AEA75 CRC64;
MSRHPQQLVH GSSLRDPESF WSHHAEQLYW HRKPSHVISR HSKSLPSGTS HDHWSWFPDG
EISTTYNCVD RHVENGNGDN VAIIWDSPVT GTKEKYTYRQ LLEEVEVLAG VLREEGVRKG
DVVIIYMPMI PAALIAALAI SRLGAIHAAV FGGFAAKSLA QRIEAARPRA IMTASCGIEG
SKGPVAYRPL VEGAIEASSF KPEKVIVWQR DQLRWNRPDK LGGQRNWQRL VKSARMRGIK
AGPVPVASTD GLYIIYTSGT TGLPKGVVRE AGGHAVGLHL SIRYLFGIQG PGDVMFCASD
IGWVVGHSYI LYAPLLVGAT TVLFEGKPVG TPDAGTFWRV IEEHRANVLF TAPTAMRAIR
KDDPDNKFFE EVARRGGLKH FRALFLAGER SEPSIVQVYQ DLLSRHAAPG AIVVDNWWSS
ESGSPISGLA LRSTAGMTFG DDKEVMPLAI RPGSAGLPMP GFDVRIVDDE GREVPRGTMG
NIVLNMPLAP TAFTRLFNDD ERFYKGYLKR FSGRWVDTGD AGMIDQDGYI HVMARTDDII
NVAAHRFSTG AIEQAILSHP EVGEASVVGI PDTLKGHLPF AFIQPRTASA ALPATPTPEL
FNAINQRVRE QIGAIASLGG MIQGRGMIPK TRSGKTLRRV LRELLEHGVR GDYGAPVSIP
PTVEDADVVE IARSKVREYF EEKQQSRAKL
//
