ID   A0A0F2L5C0_9CREN        Unreviewed;       339 AA.
AC   A0A0F2L5C0;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Aspartate-semialdehyde dehydrogenase {ECO:0000313|EMBL:KJR72678.1};
GN   ORFNames=TU36_00595 {ECO:0000313|EMBL:KJR72678.1};
OS   Vulcanisaeta sp. AZ3.
OC   Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Vulcanisaeta.
OX   NCBI_TaxID=1609231 {ECO:0000313|EMBL:KJR72678.1, ECO:0000313|Proteomes:UP000054362};
RN   [1] {ECO:0000313|EMBL:KJR72678.1, ECO:0000313|Proteomes:UP000054362}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Servin-Garciduenas L.E., Martinez-Romero E.;
RT   "Metagenome Sequencing of an Archaeal-Dominated Microbial Community from a
RT   Hot Spring at the Los Azufres Geothermal Field, Mexico.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJR72678.1}.
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DR   EMBL; JZWU01000008; KJR72678.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F2L5C0; -.
DR   PATRIC; fig|1609231.3.peg.1886; -.
DR   Proteomes; UP000054362; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR005676; Asp_semi-ald_DH_pep-lack.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR   NCBIfam; TIGR00978; asd_EA; 1.
DR   PANTHER; PTHR46718; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR46718:SF1; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   Pfam; PF02774; Semialdhyde_dhC; 1.
DR   PIRSF; PIRSF000148; ASA_dh; 1.
DR   SMART; SM00859; Semialdhyde_dh; 1.
DR   SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          5..131
FT                   /note="Semialdehyde dehydrogenase NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00859"
FT   ACT_SITE        145
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
FT   ACT_SITE        236
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
SQ   SEQUENCE   339 AA;  37534 MW;  84E92FDC4E217D05 CRC64;
     MDKLRVSILG STGLVGQWMV KLLENHPFIE VVKLSASPGK VGHKYGDSVH WFIPGDIPEY
     AKDVILSSTE PSDHKDVDIV LSALPNEIAG SIENKLLKES INVISNASPE RLSPRIPLIN
     PEVNWEHLLV LKDVKGNWLV KNPNCTATII SMPLKPIRDL IKDLYIVTLQ SVSGAGYLGV
     SYLAIDGNVI PFIKGEEEKI DVELNKMLGR QFQDRYDPWG KPISVTATRV PVKYGHMAVI
     YATLNDQVSQ EQIINKLRNF KSLPQEAELP MAPKDPIKVL DRVDAPQPAR DLDPMAVSVG
     RISIRGDVLR MVILGDNLVR GAAGVTILTL ETMRHLNLI
//