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Database: UniProt
Entry: A0A0F2LTE3_SPOSC
LinkDB: A0A0F2LTE3_SPOSC
Original site: A0A0F2LTE3_SPOSC 
ID   A0A0F2LTE3_SPOSC        Unreviewed;      4489 AA.
AC   A0A0F2LTE3;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE   AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN   ORFNames=SPSK_00366 {ECO:0000313|EMBL:KJR80124.1};
OS   Sporothrix schenckii 1099-18.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1397361 {ECO:0000313|EMBL:KJR80124.1, ECO:0000313|Proteomes:UP000033710};
RN   [1] {ECO:0000313|EMBL:KJR80124.1, ECO:0000313|Proteomes:UP000033710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1099-18 {ECO:0000313|EMBL:KJR80124.1,
RC   ECO:0000313|Proteomes:UP000033710};
RX   PubMed=25351875; DOI=10.1186/1471-2164-15-943;
RA   Teixeira M.M., de Almeida L.G., Kubitschek-Barreira P., Alves F.L.,
RA   Kioshima E.S., Abadio A.K., Fernandes L., Derengowski L.S., Ferreira K.S.,
RA   Souza R.C., Ruiz J.C., de Andrade N.C., Paes H.C., Nicola A.M.,
RA   Albuquerque P., Gerber A.L., Martins V.P., Peconick L.D., Neto A.V.,
RA   Chaucanez C.B., Silva P.A., Cunha O.L., de Oliveira F.F., dos Santos T.C.,
RA   Barros A.L., Soares M.A., de Oliveira L.M., Marini M.M.,
RA   Villalobos-Duno H., Cunha M.M., de Hoog S., da Silveira J.F., Henrissat B.,
RA   Nino-Vega G.A., Cisalpino P.S., Mora-Montes H.M., Almeida S.R.,
RA   Stajich J.E., Lopes-Bezerra L.M., Vasconcelos A.T., Felipe M.S.;
RT   "Comparative genomics of the major fungal agents of human and animal
RT   Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis.";
RL   BMC Genomics 15:943-943(2014).
RN   [2] {ECO:0000313|EMBL:KJR80124.1, ECO:0000313|Proteomes:UP000033710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1099-18 {ECO:0000313|EMBL:KJR80124.1,
RC   ECO:0000313|Proteomes:UP000033710};
RX   PubMed=25480940;
RA   Teixeira Mde M., Rodrigues A.M., Tsui C.K., de Almeida L.G.,
RA   Van Diepeningen A.D., van den Ende B.G., Fernandes G.F., Kano R.,
RA   Hamelin R.C., Lopes-Bezerra L.M., Vasconcelos A.T., de Hoog S.,
RA   de Camargo Z.P., Felipe M.S.;
RT   "Asexual propagation of a virulent clone complex in a human and feline
RT   outbreak of sporotrichosis.";
RL   Eukaryot. Cell 14:158-169(2015).
CC   -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC       intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJR80124.1}.
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DR   EMBL; AXCR01000012; KJR80124.1; -; Genomic_DNA.
DR   RefSeq; XP_016582800.1; XM_016727335.1.
DR   GeneID; 27662612; -.
DR   KEGG; ssck:SPSK_00366; -.
DR   VEuPathDB; FungiDB:SPSK_00366; -.
DR   OrthoDB; 312195at2759; -.
DR   Proteomes; UP000033710; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   CDD; cd00009; AAA; 2.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF23; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          2018..2156
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2684..2838
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          3026..3192
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          15..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1061..1082
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4062..4083
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1720..1747
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3274..3350
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3515..3556
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   4489 AA;  504306 MW;  5CE20D6B2082BCB3 CRC64;
     MDVVVPSPVV ANGISSAAGG PTSPLTPGGS AVGAGVSPSS YVDPARVVDH IAAVLEAALG
     ATREELEAPG SLLSKSRYAD TVQRCSRFAH EPQVVSLYIQ KDLLPTSAIT QVAATPSRLG
     NADENDNSPK PSAPSHVFSL AADLSAISMT VAFLVLLKRP QPLDPNVPIT SQVQMLNLPG
     PAYLTATAGE QGLSTSPFEI LQMYLHNGLA PYFDASTKPA VNAASANGTS STSRVRADLE
     AKTGVPVTKK RWTELELSLA HLQQNVEIPE VVLPFPPIVQ TALDDAAARG VRPFFDQLPQ
     GVTQDTAMLN SLQATVNTWI KSIQVITKMT QDPSTGTANQ EINYWLSMES ALERIETQLR
     GDGVSLTLDI LKHAKRFQAT VSFVADTGLK EAMERVQKYN QLMRDFPLDE LLSATTLAKV
     EDSIVQIFGH LNKKLRICPY PIRRALALVE SISGDLDDAM HRLLPGTELV DLDYNEFNRV
     MSAANGIFRA WDDVVKEFTN VAREVTRRRN DKFIPIKINP RHAQLQARLK YIQNFRENHE
     QLQRTIVTVL GTKESNADGA DTSAASNGSA VVAANGFGGP SGFEETSDVD AVEEVRQAWE
     ALRNVDLLDV TPEGTTKWVR AENTYNERTA RVENSIIARL RDRLATAKNA NEMFRVFSKF
     NALFVRPKIR GAIAEYQTQL IDNVKQAIAA LHERFKQQYG HSEAHAMATL HDLPPVSGAI
     IWARQIERQL DNYMKKVEDV LGADWALHAE GQKLQNESIQ FRKKLKTAPI FEAWARDTMR
     REVSIAGRLF SIKRVRSAGN TLELAVNFDP QVIALFKETR NLIWLNCSVP HAVNSVAKDA
     KRVYPYAVSL MESVRTFAQT LRTINEMPEV SMLLNGHRND VYALIAKGVP LRWESFVNSY
     EVHLRGLPSH MSNGSIGGGA GGAMDRLKGG ESRHVLFVRE IAAAVSLLQT KTATLATYRA
     TIQKSMRELA TCPYEAAAFE SRLRSIQEAV DQLNLQQYAN LAYWVEGMNR QIKATLLTRL
     QRAIQAWIEA FEDDVSADGN KQTKSSFGTI GLSNASANTT STRRKQIAAN DASAAATTPD
     DTPTMKQLVH EITMRNQLIY LDPPLEFARA SWYLRLQDWL GVVCNLRKIK ATSYEMRLGT
     TVVEDTRFND LPADCTPMLL RVQTSIETKL QAISGYVDEW LRFQSLWDLQ SEKVYDLLGD
     RLARWLQLLQ EIRKTRQTFD TTEVSRSFGH ITIDYDQVQT KVNAKYDQWQ HDILLKFAGR
     LGNRMREVYA EIGKARTDLE TLSLEVNSTA HAVQFITIVQ SCKRHVKLWA PEIETFRQGE
     STLVRQRYQF PNDWLHAQQV DHEWNSLNEL LSRKDKIVQD QTDALRAKII AEDKIVVDKI
     AEIAVQWNEE KPVSGTIAPD IATATLAAFE SRITAFQEEA AMVAKAKEAL DLPPTAETSL
     AGILEEVHDF KSVWASLSLI WKNLNEQREM LWNSVQPRKV RTAMDNLIKM TRDMPSRMRQ
     YAAFEHIQNI LKTYVRVNPL LSDLKSEAVR DRHWTKIYKQ IKPGKRYSPV SMTLGDVWDL
     NLVATEAIIK DIIAQAQGEM ALEEFLKQVR ETWTSYNLEL VNYQNKCRLI RGWDDLFAKC
     SENLNSLQAM KHSPYYKEFE EEASSWEDKL NRVHVLFDVW IDVQRQWVYL EGVFTGNADI
     KHLLPIESSR FQNINSEFSA VMKKVYKQPY VLDVLNIPNV QKSLERLAEL LNKIQKALGE
     YLEKERVSFP RFYFVGDEDL LEMIGNSNDT MRIAKHFKKM FAGLSGLTME DETVITGFTS
     KEGEIIRLKR DISLIKTPRI NDWLALLEGG MKATLAELLA EAVAVYTPIF TAENGIDKAA
     LAEFMETFPS QIVVLATQVV WTTVVDKALS EGGSGLKDLF EREVEVLRLL ASTVLGDLHV
     LMRKKCEQLI TECVHQRDII EKLMKLNANS PTHYMWLLQM RYVYAAEGDA QQRLSIKMAN
     ASLQYGFEYL GVPDRLVRTP LTDRCFLTLT QALCQRLGGS PYGPAGTGKT ESVKALGVEL
     GRFTLVFCCD DTFDFQAMGR IFLGICQVGA WGCFDEFNRL EERILSAVSQ QIQNIQLGLK
     QGAEDDKAQI ELVGRQLHVN ASTGIFITMN PGYAGRSNLP DNLKKLFRSV AMSKPDKELI
     AEVMLYSQGF NQAKVLSKQT VPFFDQCAAK LSKQAHYDFG LRALKSVLVS SGGLKRARLT
     EGGDGVLSVE DSGEVVEPEI IVQSIRETIA PKLIKSDVEI LAGIETACFP GVRYVPANLE
     ALEAAIRRLA DERQLVVNDT WLTKVLQLYQ IQGIHHGVMM VGSSGSGKSA AWRLLLDAMQ
     QVEKVEGVSH VIDSKVMSKE ALYGNLDSTT REWTDGLFTS ILRKIVDNLR GEDSKRHWIV
     FDGDVDPEWV ENLNSVLDDN KLLTLPNGER LNLPPNVRIM FEVENLKYAT LATVSRCGMV
     WFSEDTVTPS MMVSNYLGTL ATVAFEDFDE DAVATGQSAA KALAVQTHAA ELLKTYLTGD
     DFILQALRLA DTQTYRHIME FTIARVLTTL FSLLNKAVRN VIEYNSQHSD FPLEAEQVEA
     YISKKLLLAL VWALTGDCPL DDRKAFGDSI VGLASFGSPP LDSGSGGSSL IDFDVSLPRA
     EWTAWQNQVP TIEVNTHSVT QTDVVIPTLD TVRHEDVLYS WLAEHKPLLL CGPPGSGKTM
     TLFSALRKLP NMEVVGLNFS SATTPDLLIK SFEQYCEYKK TLNGVMLSPT QIGRWLVVFC
     DEINLPAPDK YGTQRAISFL RQLVEHNGFW RTSDKAWVTL DRIQFVGACN PPTDAGRTPL
     GPRFLRHAPL IMVDYPGEQS LHQIYGTFNA AVLKIIPSLR GYAEPLTQAM VKFYLESQRR
     FTPQIQPHYV YSPRELTRWV RGVYEAIRPL ESLPVEGLIR IWAHEALRLF QDRLVAEEER
     RWTDDAVRRI ATELFPNIDE EKALGGPILF SNWLSKNYVP VDREQLRDFV KARLRTFCEE
     EVDVPLILFN DVLEHVLRID RVFRQPQGHL ILIGVSGSGK TTLSRFVAWM NGLKVFQIKV
     HGKYSSEDFD EDLREVLRRS GCKGEKICFI MDEANVLDSG FLERMNTLLA NAEVPGLFEG
     DDLAALMTAC KEGAQRQGLH LDSQEELYKW FTSQIVKNLH VVFTMNPPED GLSSKAATSP
     ALFNRCVLNW FGDWSDQALY QVGHELTQSV DLDRPNFEAP DTIPVAYRGL TLPASHRSAV
     INAMVYIHYS LQRFNARLLK QQGKVTFLTP RHFLDFVAQY VKLYNEKRED LEEQQRHLNV
     GLEKLRDTVD KVRDLRVSLA DKKAQLEKKD AEANEKLQRM VADQREAEQR KSTSLEIQAA
     LEIQEAEVAS RKKIVLEDLA RAEPAVEAAK ASVSNIKRQQ LTEVRSMTSP PQGVRLTLDS
     VCTLLGHKVV GDWRAIQGVV RRDDFIASII NFNNEKMMTR SLRLKMRNEF LSNPEFTFEK
     VNRASKACGP LVQWVEAQVN YAEILDRVGP LRDEVTQLED QALQTKAQAK AVENTIETLE
     ASIATYKTEY AALISETQAI KAEMTRVQFK VDRSVRLLDS LSSERVRWEE GSRSFETQIG
     TLVGDVLVAA AFLAYSGLYD QTFRKSMMDD WLHQLQLSGI NTKQHNPVTE YLSTADERLG
     WQENMLPVDD LCTENAIILK RFNRYPLIID PSGRVTEFLQ RECKDRRLTV TSFLDDSFAK
     QLESSLRFGN PILIQDAEHL DPLLNHVLNK EYQKTGGRVL IQLGKQQIDF SPAFKLYLST
     RDPSATFAPD ICSRTTFVNF TVTQGSLQTQ SLNDVLKSER PDVDERRSNL IKLQGEFKVH
     LRQLEKRLLQ ALNESRGNIL DDDNVIETLE TLKTEAAEIS AKMNSTEGVM AEVEQITLQY
     AIIARACSAV FAVLEQLHYL NHFYQFSLQY FLDIFHSVLH NNPHLTGETD YNVRRDTIVR
     DLFATTFKRT ALGVLQKDRI TLAMLLVQAA PYKMDKGLID VLLDERVQGR DASATDNNSG
     REGAMAIARR LPALKDKIDN VSEVEWSRFL SEELAETVVP PSILQGDVGN NDEKPPTTAA
     EAEAANNSAA YNNALLSLLM VKLFRLDRFV PAAEKFVTLV FGDDLFDIVE DLEGTVTQVS
     ATRPIALVSS PGFDASYKVD NLVERMNVRC TNIAMGSAEG LASADKAVSN AAQMGSWVLV
     KNVHLAPTWL QSLEKRMESL NPHADFRLFL SMESSPKIPV NLLRASRVLM YEQPAGVRAN
     MKDSMSSLAT RSSRPPVERT RLYLLLSFLH AVVQERLRYA PNLGWKGFWE FNDSDVRSPF
     LIRLPFVHFM SSCLLTVSQY ECSAFVVDTW LETVAGNRSN IAPQNIPWDM IRYLVRETYG
     GKIDDEGDFQ RLQQLVDGIL TPAAYDIGHK LVEEDAESKS SGLVVPAGTS LPDCMAWIQK
     LPEREPPTYL GLPANAEKLL LVGLGESLVR DLKKVTDLLD EGEQLMAEA
//
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