ID A0A0F2LTE3_SPOSC Unreviewed; 4489 AA.
AC A0A0F2LTE3;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=SPSK_00366 {ECO:0000313|EMBL:KJR80124.1};
OS Sporothrix schenckii 1099-18.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1397361 {ECO:0000313|EMBL:KJR80124.1, ECO:0000313|Proteomes:UP000033710};
RN [1] {ECO:0000313|EMBL:KJR80124.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR80124.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25351875; DOI=10.1186/1471-2164-15-943;
RA Teixeira M.M., de Almeida L.G., Kubitschek-Barreira P., Alves F.L.,
RA Kioshima E.S., Abadio A.K., Fernandes L., Derengowski L.S., Ferreira K.S.,
RA Souza R.C., Ruiz J.C., de Andrade N.C., Paes H.C., Nicola A.M.,
RA Albuquerque P., Gerber A.L., Martins V.P., Peconick L.D., Neto A.V.,
RA Chaucanez C.B., Silva P.A., Cunha O.L., de Oliveira F.F., dos Santos T.C.,
RA Barros A.L., Soares M.A., de Oliveira L.M., Marini M.M.,
RA Villalobos-Duno H., Cunha M.M., de Hoog S., da Silveira J.F., Henrissat B.,
RA Nino-Vega G.A., Cisalpino P.S., Mora-Montes H.M., Almeida S.R.,
RA Stajich J.E., Lopes-Bezerra L.M., Vasconcelos A.T., Felipe M.S.;
RT "Comparative genomics of the major fungal agents of human and animal
RT Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis.";
RL BMC Genomics 15:943-943(2014).
RN [2] {ECO:0000313|EMBL:KJR80124.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR80124.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25480940;
RA Teixeira Mde M., Rodrigues A.M., Tsui C.K., de Almeida L.G.,
RA Van Diepeningen A.D., van den Ende B.G., Fernandes G.F., Kano R.,
RA Hamelin R.C., Lopes-Bezerra L.M., Vasconcelos A.T., de Hoog S.,
RA de Camargo Z.P., Felipe M.S.;
RT "Asexual propagation of a virulent clone complex in a human and feline
RT outbreak of sporotrichosis.";
RL Eukaryot. Cell 14:158-169(2015).
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJR80124.1}.
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DR EMBL; AXCR01000012; KJR80124.1; -; Genomic_DNA.
DR RefSeq; XP_016582800.1; XM_016727335.1.
DR GeneID; 27662612; -.
DR KEGG; ssck:SPSK_00366; -.
DR VEuPathDB; FungiDB:SPSK_00366; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000033710; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF23; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2018..2156
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2684..2838
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 3026..3192
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 15..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4062..4083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1720..1747
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3274..3350
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3515..3556
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4489 AA; 504306 MW; 5CE20D6B2082BCB3 CRC64;
MDVVVPSPVV ANGISSAAGG PTSPLTPGGS AVGAGVSPSS YVDPARVVDH IAAVLEAALG
ATREELEAPG SLLSKSRYAD TVQRCSRFAH EPQVVSLYIQ KDLLPTSAIT QVAATPSRLG
NADENDNSPK PSAPSHVFSL AADLSAISMT VAFLVLLKRP QPLDPNVPIT SQVQMLNLPG
PAYLTATAGE QGLSTSPFEI LQMYLHNGLA PYFDASTKPA VNAASANGTS STSRVRADLE
AKTGVPVTKK RWTELELSLA HLQQNVEIPE VVLPFPPIVQ TALDDAAARG VRPFFDQLPQ
GVTQDTAMLN SLQATVNTWI KSIQVITKMT QDPSTGTANQ EINYWLSMES ALERIETQLR
GDGVSLTLDI LKHAKRFQAT VSFVADTGLK EAMERVQKYN QLMRDFPLDE LLSATTLAKV
EDSIVQIFGH LNKKLRICPY PIRRALALVE SISGDLDDAM HRLLPGTELV DLDYNEFNRV
MSAANGIFRA WDDVVKEFTN VAREVTRRRN DKFIPIKINP RHAQLQARLK YIQNFRENHE
QLQRTIVTVL GTKESNADGA DTSAASNGSA VVAANGFGGP SGFEETSDVD AVEEVRQAWE
ALRNVDLLDV TPEGTTKWVR AENTYNERTA RVENSIIARL RDRLATAKNA NEMFRVFSKF
NALFVRPKIR GAIAEYQTQL IDNVKQAIAA LHERFKQQYG HSEAHAMATL HDLPPVSGAI
IWARQIERQL DNYMKKVEDV LGADWALHAE GQKLQNESIQ FRKKLKTAPI FEAWARDTMR
REVSIAGRLF SIKRVRSAGN TLELAVNFDP QVIALFKETR NLIWLNCSVP HAVNSVAKDA
KRVYPYAVSL MESVRTFAQT LRTINEMPEV SMLLNGHRND VYALIAKGVP LRWESFVNSY
EVHLRGLPSH MSNGSIGGGA GGAMDRLKGG ESRHVLFVRE IAAAVSLLQT KTATLATYRA
TIQKSMRELA TCPYEAAAFE SRLRSIQEAV DQLNLQQYAN LAYWVEGMNR QIKATLLTRL
QRAIQAWIEA FEDDVSADGN KQTKSSFGTI GLSNASANTT STRRKQIAAN DASAAATTPD
DTPTMKQLVH EITMRNQLIY LDPPLEFARA SWYLRLQDWL GVVCNLRKIK ATSYEMRLGT
TVVEDTRFND LPADCTPMLL RVQTSIETKL QAISGYVDEW LRFQSLWDLQ SEKVYDLLGD
RLARWLQLLQ EIRKTRQTFD TTEVSRSFGH ITIDYDQVQT KVNAKYDQWQ HDILLKFAGR
LGNRMREVYA EIGKARTDLE TLSLEVNSTA HAVQFITIVQ SCKRHVKLWA PEIETFRQGE
STLVRQRYQF PNDWLHAQQV DHEWNSLNEL LSRKDKIVQD QTDALRAKII AEDKIVVDKI
AEIAVQWNEE KPVSGTIAPD IATATLAAFE SRITAFQEEA AMVAKAKEAL DLPPTAETSL
AGILEEVHDF KSVWASLSLI WKNLNEQREM LWNSVQPRKV RTAMDNLIKM TRDMPSRMRQ
YAAFEHIQNI LKTYVRVNPL LSDLKSEAVR DRHWTKIYKQ IKPGKRYSPV SMTLGDVWDL
NLVATEAIIK DIIAQAQGEM ALEEFLKQVR ETWTSYNLEL VNYQNKCRLI RGWDDLFAKC
SENLNSLQAM KHSPYYKEFE EEASSWEDKL NRVHVLFDVW IDVQRQWVYL EGVFTGNADI
KHLLPIESSR FQNINSEFSA VMKKVYKQPY VLDVLNIPNV QKSLERLAEL LNKIQKALGE
YLEKERVSFP RFYFVGDEDL LEMIGNSNDT MRIAKHFKKM FAGLSGLTME DETVITGFTS
KEGEIIRLKR DISLIKTPRI NDWLALLEGG MKATLAELLA EAVAVYTPIF TAENGIDKAA
LAEFMETFPS QIVVLATQVV WTTVVDKALS EGGSGLKDLF EREVEVLRLL ASTVLGDLHV
LMRKKCEQLI TECVHQRDII EKLMKLNANS PTHYMWLLQM RYVYAAEGDA QQRLSIKMAN
ASLQYGFEYL GVPDRLVRTP LTDRCFLTLT QALCQRLGGS PYGPAGTGKT ESVKALGVEL
GRFTLVFCCD DTFDFQAMGR IFLGICQVGA WGCFDEFNRL EERILSAVSQ QIQNIQLGLK
QGAEDDKAQI ELVGRQLHVN ASTGIFITMN PGYAGRSNLP DNLKKLFRSV AMSKPDKELI
AEVMLYSQGF NQAKVLSKQT VPFFDQCAAK LSKQAHYDFG LRALKSVLVS SGGLKRARLT
EGGDGVLSVE DSGEVVEPEI IVQSIRETIA PKLIKSDVEI LAGIETACFP GVRYVPANLE
ALEAAIRRLA DERQLVVNDT WLTKVLQLYQ IQGIHHGVMM VGSSGSGKSA AWRLLLDAMQ
QVEKVEGVSH VIDSKVMSKE ALYGNLDSTT REWTDGLFTS ILRKIVDNLR GEDSKRHWIV
FDGDVDPEWV ENLNSVLDDN KLLTLPNGER LNLPPNVRIM FEVENLKYAT LATVSRCGMV
WFSEDTVTPS MMVSNYLGTL ATVAFEDFDE DAVATGQSAA KALAVQTHAA ELLKTYLTGD
DFILQALRLA DTQTYRHIME FTIARVLTTL FSLLNKAVRN VIEYNSQHSD FPLEAEQVEA
YISKKLLLAL VWALTGDCPL DDRKAFGDSI VGLASFGSPP LDSGSGGSSL IDFDVSLPRA
EWTAWQNQVP TIEVNTHSVT QTDVVIPTLD TVRHEDVLYS WLAEHKPLLL CGPPGSGKTM
TLFSALRKLP NMEVVGLNFS SATTPDLLIK SFEQYCEYKK TLNGVMLSPT QIGRWLVVFC
DEINLPAPDK YGTQRAISFL RQLVEHNGFW RTSDKAWVTL DRIQFVGACN PPTDAGRTPL
GPRFLRHAPL IMVDYPGEQS LHQIYGTFNA AVLKIIPSLR GYAEPLTQAM VKFYLESQRR
FTPQIQPHYV YSPRELTRWV RGVYEAIRPL ESLPVEGLIR IWAHEALRLF QDRLVAEEER
RWTDDAVRRI ATELFPNIDE EKALGGPILF SNWLSKNYVP VDREQLRDFV KARLRTFCEE
EVDVPLILFN DVLEHVLRID RVFRQPQGHL ILIGVSGSGK TTLSRFVAWM NGLKVFQIKV
HGKYSSEDFD EDLREVLRRS GCKGEKICFI MDEANVLDSG FLERMNTLLA NAEVPGLFEG
DDLAALMTAC KEGAQRQGLH LDSQEELYKW FTSQIVKNLH VVFTMNPPED GLSSKAATSP
ALFNRCVLNW FGDWSDQALY QVGHELTQSV DLDRPNFEAP DTIPVAYRGL TLPASHRSAV
INAMVYIHYS LQRFNARLLK QQGKVTFLTP RHFLDFVAQY VKLYNEKRED LEEQQRHLNV
GLEKLRDTVD KVRDLRVSLA DKKAQLEKKD AEANEKLQRM VADQREAEQR KSTSLEIQAA
LEIQEAEVAS RKKIVLEDLA RAEPAVEAAK ASVSNIKRQQ LTEVRSMTSP PQGVRLTLDS
VCTLLGHKVV GDWRAIQGVV RRDDFIASII NFNNEKMMTR SLRLKMRNEF LSNPEFTFEK
VNRASKACGP LVQWVEAQVN YAEILDRVGP LRDEVTQLED QALQTKAQAK AVENTIETLE
ASIATYKTEY AALISETQAI KAEMTRVQFK VDRSVRLLDS LSSERVRWEE GSRSFETQIG
TLVGDVLVAA AFLAYSGLYD QTFRKSMMDD WLHQLQLSGI NTKQHNPVTE YLSTADERLG
WQENMLPVDD LCTENAIILK RFNRYPLIID PSGRVTEFLQ RECKDRRLTV TSFLDDSFAK
QLESSLRFGN PILIQDAEHL DPLLNHVLNK EYQKTGGRVL IQLGKQQIDF SPAFKLYLST
RDPSATFAPD ICSRTTFVNF TVTQGSLQTQ SLNDVLKSER PDVDERRSNL IKLQGEFKVH
LRQLEKRLLQ ALNESRGNIL DDDNVIETLE TLKTEAAEIS AKMNSTEGVM AEVEQITLQY
AIIARACSAV FAVLEQLHYL NHFYQFSLQY FLDIFHSVLH NNPHLTGETD YNVRRDTIVR
DLFATTFKRT ALGVLQKDRI TLAMLLVQAA PYKMDKGLID VLLDERVQGR DASATDNNSG
REGAMAIARR LPALKDKIDN VSEVEWSRFL SEELAETVVP PSILQGDVGN NDEKPPTTAA
EAEAANNSAA YNNALLSLLM VKLFRLDRFV PAAEKFVTLV FGDDLFDIVE DLEGTVTQVS
ATRPIALVSS PGFDASYKVD NLVERMNVRC TNIAMGSAEG LASADKAVSN AAQMGSWVLV
KNVHLAPTWL QSLEKRMESL NPHADFRLFL SMESSPKIPV NLLRASRVLM YEQPAGVRAN
MKDSMSSLAT RSSRPPVERT RLYLLLSFLH AVVQERLRYA PNLGWKGFWE FNDSDVRSPF
LIRLPFVHFM SSCLLTVSQY ECSAFVVDTW LETVAGNRSN IAPQNIPWDM IRYLVRETYG
GKIDDEGDFQ RLQQLVDGIL TPAAYDIGHK LVEEDAESKS SGLVVPAGTS LPDCMAWIQK
LPEREPPTYL GLPANAEKLL LVGLGESLVR DLKKVTDLLD EGEQLMAEA
//