ID A0A0F2M8H7_SPOSC Unreviewed; 972 AA.
AC A0A0F2M8H7;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=DNA mismatch repair protein MSH4 {ECO:0000313|EMBL:KJR85988.1};
GN ORFNames=SPSK_08402 {ECO:0000313|EMBL:KJR85988.1};
OS Sporothrix schenckii 1099-18.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1397361 {ECO:0000313|EMBL:KJR85988.1, ECO:0000313|Proteomes:UP000033710};
RN [1] {ECO:0000313|EMBL:KJR85988.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR85988.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25351875; DOI=10.1186/1471-2164-15-943;
RA Teixeira M.M., de Almeida L.G., Kubitschek-Barreira P., Alves F.L.,
RA Kioshima E.S., Abadio A.K., Fernandes L., Derengowski L.S., Ferreira K.S.,
RA Souza R.C., Ruiz J.C., de Andrade N.C., Paes H.C., Nicola A.M.,
RA Albuquerque P., Gerber A.L., Martins V.P., Peconick L.D., Neto A.V.,
RA Chaucanez C.B., Silva P.A., Cunha O.L., de Oliveira F.F., dos Santos T.C.,
RA Barros A.L., Soares M.A., de Oliveira L.M., Marini M.M.,
RA Villalobos-Duno H., Cunha M.M., de Hoog S., da Silveira J.F., Henrissat B.,
RA Nino-Vega G.A., Cisalpino P.S., Mora-Montes H.M., Almeida S.R.,
RA Stajich J.E., Lopes-Bezerra L.M., Vasconcelos A.T., Felipe M.S.;
RT "Comparative genomics of the major fungal agents of human and animal
RT Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis.";
RL BMC Genomics 15:943-943(2014).
RN [2] {ECO:0000313|EMBL:KJR85988.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR85988.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25480940;
RA Teixeira Mde M., Rodrigues A.M., Tsui C.K., de Almeida L.G.,
RA Van Diepeningen A.D., van den Ende B.G., Fernandes G.F., Kano R.,
RA Hamelin R.C., Lopes-Bezerra L.M., Vasconcelos A.T., de Hoog S.,
RA de Camargo Z.P., Felipe M.S.;
RT "Asexual propagation of a virulent clone complex in a human and feline
RT outbreak of sporotrichosis.";
RL Eukaryot. Cell 14:158-169(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJR85988.1}.
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DR EMBL; AXCR01000007; KJR85988.1; -; Genomic_DNA.
DR RefSeq; XP_016588664.1; XM_016735000.1.
DR AlphaFoldDB; A0A0F2M8H7; -.
DR GeneID; 27670277; -.
DR KEGG; ssck:SPSK_08402; -.
DR VEuPathDB; FungiDB:SPSK_08402; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000033710; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 692..708
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 797..827
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 107592 MW; 322495041F043C35 CRC64;
MYSKKTAHRG LAGSSQPSVR SFTTPTSSRW AAINTQNALN PPSAYNPPST LQRRSTGSGV
GSGRASGTIS RPSGTDQRPP FPIGPDENRG VVCAVCDSNN VNRTVGLAFV NVPIAEAVLT
NVADTQYYQG TIHKIQMMEV SRILMQPTPA SSVQSGLALR PHIEEELRGL PIVERAKPDW
SADDGMLALQ RVAFTEDLPS LEVAVKDNFH LLCAFSAAMK FLTDDMGIDF DDHSVRIKYQ
PPSDAMMISL PTIRSLELIQ NSINSSSKDC LYGLLNRTTT PMGSRVLRSN IVQPSTLAVV
LNPRYEAVGE LVHKDGLLDK VVEVLQKLKP LGDVERLLTK LVILPKDGSI YESEQAINNI
LKLKAFLTAI PDVFQSLSDV SCDLLLEIRS NCLPARADRI LGILADTIDR DAAYATKPLE
LRNQRVHTVK PEISASLDIQ RKLYEDFSRK IHDYVNELED EIRVKVALKY TATRKFYLKV
NAKDFGPQGP PSVLVNTTTV KGAIECQTLK LMGYNERINE AVHRAIVESD EVIKSLLSQI
RPRVSRLFKY CECIALLDLL ASFATSTRTY AYKRPLIHTD SYALVGGRHP ILDSRGHNKC
IPNDYFVTEE TRFQIITGQN MSGKSTYIRA IAMLQIMAQI GCYIPAESAC IPIMHSLFAR
VSTDDTMEQN QSTFSIEMRE MAFILRNVNN KSLVIVDELG RSTSTQDGLA IAAAMSEALL
QSNATVYFAT HFSELAKALA INIGVVNRHL RTVTEYSESA THVPVTNMLY RVAEGPEPEV
SYGIALAKAV GFPATFIAHA EKVAAELRAE AQASKRDRQE MEEAKRRKLV ANLVRQLKLA
YVSDAGDEEL MEYLTQIYDD FCAKMIGSID DEDAIVEEDS NENESDDEGD GQHDGAEENM
ARVARKGQYA VRRPSDLGLF GGGTDDDVDD YDDLYQPGSA ANAIVIDDDE EFDEDHMSDM
EDMGNDYSEE MY
//
