ID A0A0F2MBK8_SPOSC Unreviewed; 720 AA.
AC A0A0F2MBK8;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 22-FEB-2023, entry version 34.
DE SubName: Full=Ras guanyl-nucleotide exchange factor RasGEF {ECO:0000313|EMBL:KJR87017.1};
GN ORFNames=SPSK_01524 {ECO:0000313|EMBL:KJR87017.1};
OS Sporothrix schenckii 1099-18.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1397361 {ECO:0000313|EMBL:KJR87017.1, ECO:0000313|Proteomes:UP000033710};
RN [1] {ECO:0000313|EMBL:KJR87017.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR87017.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25351875; DOI=10.1186/1471-2164-15-943;
RA Teixeira M.M., de Almeida L.G., Kubitschek-Barreira P., Alves F.L.,
RA Kioshima E.S., Abadio A.K., Fernandes L., Derengowski L.S., Ferreira K.S.,
RA Souza R.C., Ruiz J.C., de Andrade N.C., Paes H.C., Nicola A.M.,
RA Albuquerque P., Gerber A.L., Martins V.P., Peconick L.D., Neto A.V.,
RA Chaucanez C.B., Silva P.A., Cunha O.L., de Oliveira F.F., dos Santos T.C.,
RA Barros A.L., Soares M.A., de Oliveira L.M., Marini M.M.,
RA Villalobos-Duno H., Cunha M.M., de Hoog S., da Silveira J.F., Henrissat B.,
RA Nino-Vega G.A., Cisalpino P.S., Mora-Montes H.M., Almeida S.R.,
RA Stajich J.E., Lopes-Bezerra L.M., Vasconcelos A.T., Felipe M.S.;
RT "Comparative genomics of the major fungal agents of human and animal
RT Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis.";
RL BMC Genomics 15:943-943(2014).
RN [2] {ECO:0000313|EMBL:KJR87017.1, ECO:0000313|Proteomes:UP000033710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1099-18 {ECO:0000313|EMBL:KJR87017.1,
RC ECO:0000313|Proteomes:UP000033710};
RX PubMed=25480940;
RA Teixeira Mde M., Rodrigues A.M., Tsui C.K., de Almeida L.G.,
RA Van Diepeningen A.D., van den Ende B.G., Fernandes G.F., Kano R.,
RA Hamelin R.C., Lopes-Bezerra L.M., Vasconcelos A.T., de Hoog S.,
RA de Camargo Z.P., Felipe M.S.;
RT "Asexual propagation of a virulent clone complex in a human and feline
RT outbreak of sporotrichosis.";
RL Eukaryot. Cell 14:158-169(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJR87017.1}.
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DR EMBL; AXCR01000005; KJR87017.1; -; Genomic_DNA.
DR RefSeq; XP_016589693.1; XM_016728435.1.
DR AlphaFoldDB; A0A0F2MBK8; -.
DR GeneID; 27663712; -.
DR KEGG; ssck:SPSK_01524; -.
DR VEuPathDB; FungiDB:SPSK_01524; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000033710; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..720
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002455129"
FT DOMAIN 223..349
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 467..705
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 30..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 80255 MW; CBDAB70AB2F96F7C CRC64;
MLFFILSVLL GSFNATGSCP SNTIAFRSIG DKSNSHHNHN RHQHHNTYSS SSTTTTNTSA
PGTTTANTNS TGTTASTTTT RRRAASSAAH LDAPPDRING RPQSSEQGSG KHSRASSDLS
LLRGVTTSTS GDRDGYYRSQ NSRSPRVDSP NAQQQINTSS FGAEMTDERS TQSVQGMLRS
TGVRLDAGQD SFLDIEESDA ESLRRFSEDV PILQRNDDNM FDIPAKAAGI PFNDLVERLL
AAPMNRADAN FSDVFLCLYR KFAAPHELLS AIISALTKTW EDKASHFLER TATQFRYIEV
LNRWVSLYPG DFARPASRKQ LEVLIYRLAE EPIFTLSAQQ IKKHLDNDVA EDDDTWWAKC
DDAPQDEPTA AGATPSEEQP PADSLRSLTL QNSQSSDQPS SEAGSGGAGA SASGSSGTLA
ATLGSGRGLA HFQYHSYEDY EREAATMVPM ATLPLNKFRY HIFMDMDANE VADEITRIDW
IMFSSIRIRD LVRHVSLSAQ EKERCRSLRN MDRMISHFNH IAKWVANMIL IRDKAKHRAP
CLQKFMAIAL RLRQLRNYNG LAAMLAGINS TAIHRLAQTR ALVDPDIQKS FARLVLLMST
QKSHFAYRLA WENSPLPRIP FMPLHRRDLV SAEEGSRTFV GPQGDRVNWK KFEVLGEVLL
PLMKSQGTPY PNLKKHQPSR EMILDCRMPM DEEDIYQRSV QVEPTGGAAD LKKKFPWLPK
//
