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Database: UniProt
Entry: A0A0F2NWJ2_9FLAO
LinkDB: A0A0F2NWJ2_9FLAO
Original site: A0A0F2NWJ2_9FLAO 
ID   A0A0F2NWJ2_9FLAO        Unreviewed;       477 AA.
AC   A0A0F2NWJ2;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   25-OCT-2017, entry version 18.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=VR77_05315 {ECO:0000313|EMBL:KJS06418.1};
OS   Flavobacteriales bacterium BRH_c54.
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales.
OX   NCBI_TaxID=1629721 {ECO:0000313|EMBL:KJS06418.1, ECO:0000313|Proteomes:UP000033681};
RN   [1] {ECO:0000313|EMBL:KJS06418.1, ECO:0000313|Proteomes:UP000033681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRH_c54 {ECO:0000313|EMBL:KJS06418.1};
RA   Bagnoud A., Chourey K., Hettich R.L., de Bruijn I., Andersson A.F.,
RA   Leupin O.X., Schwyn B., Bernier-Latmani R.;
RT   "Microbial metabolic network in the subsurface.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KJS06418.1}.
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DR   EMBL; LADZ01000021; KJS06418.1; -; Genomic_DNA.
DR   PATRIC; fig|1629721.3.peg.807; -.
DR   Proteomes; UP000033681; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000033681};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033681}.
FT   DOMAIN      173    303       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      384    453       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     181    188       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   477 AA;  54389 MW;  55C4138887B27206 CRC64;
     MDKNFTSVWE NCLQVIKDNV SLQSYKTWFE PIVPVKLKDK VLTIQVPSQF FYEWLEEHYV
     SILKKTIKKE LGNEGRLEYS IVIENNNKTN NPYTLKIPAT NKPHIKNNPV NMPIDLNKNK
     SIRNPFIIPG IAHLNVESQL NPNYSFDNFV EGDCNRLARS AGFAVSNNPG GTSFNPLLVY
     GGVGLGKTHL AHAIGIEVKN KFPNKIVLYV SSEKFTQQFI DAVKNNEQND FIHFYQMIDV
     LIIDDVQFFA GKAKTQDVFF HIFNHLHQSG KQIILTADKA PVEIIGMEQR LLSRFKWGLA
     ADLQSPDLET RIAILEKKMY SEGLELPKDV VEYIAYSITT NVRELEGALI SILAQSSLNK
     KAVNIDLARQ MVDKFVKNTA REVSIDYIQK VVCDYFDMPI ETLKSKTRKR EVVQARQIAM
     YFSKQMTKSS LASIGMHCGG KDHATVLHAC KTVNNLMDTD KRFRGYIEEL KKKISLQ
//
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