ID   A0A0F2P1H6_9GAMM        Unreviewed;       285 AA.
AC   A0A0F2P1H6;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Oxidoreductase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=VR73_06800 {ECO:0000313|EMBL:KJS08159.1};
OS   Gammaproteobacteria bacterium BRH_c0.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria.
OX   NCBI_TaxID=1629722 {ECO:0000313|EMBL:KJS08159.1, ECO:0000313|Proteomes:UP000033581};
RN   [1] {ECO:0000313|EMBL:KJS08159.1, ECO:0000313|Proteomes:UP000033581}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRH_c0 {ECO:0000313|EMBL:KJS08159.1};
RA   Bagnoud A., Chourey K., Hettich R.L., de Bruijn I., Andersson A.F.,
RA   Leupin O.X., Schwyn B., Bernier-Latmani R.;
RT   "Microbial metabolic network in the subsurface.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJS08159.1}.
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DR   EMBL; LADM01000051; KJS08159.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F2P1H6; -.
DR   STRING; 1629722.VR73_06800; -.
DR   Proteomes; UP000033581; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          13..168
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          171..276
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        177
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   285 AA;  29996 MW;  39FE0EB4430DC8F5 CRC64;
     MNTTSNSTNL RAGVIGLGQI GGGVAICLAR HQRPLAVYDI RHDAAEKLEG VPAVLASPAD
     VARASDVLMI AVLNGAQARA TLEGPDGVLA GAHPGLTLVM LSTITMDELK ELVALAAEHH
     VALLDCGVTA GGLSAKGEMI SMIGGDDAVV ERIMPVLNEF NAEVHHMGPT GAGMATKIAR
     NMIHFTVWRA GFEGARLASQ AGVDVGKFID LVENASRKHG ASVTFWMDPE RIAPGSDPLE
     IGKHTLIYHK KDMNTAKELA QQLGVETPTA DIARVMGAET YRVED
//