ID   A0A0F2S1X4_9RHOB        Unreviewed;       814 AA.
AC   A0A0F2S1X4;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Dimethylglycine dehydrogenase {ECO:0000313|EMBL:KJS43432.1};
GN   ORFNames=VR71_10250 {ECO:0000313|EMBL:KJS43432.1};
OS   Roseovarius sp. BRH_c41.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseovarius.
OX   NCBI_TaxID=1629709 {ECO:0000313|EMBL:KJS43432.1, ECO:0000313|Proteomes:UP000033676};
RN   [1] {ECO:0000313|EMBL:KJS43432.1, ECO:0000313|Proteomes:UP000033676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRH_c41 {ECO:0000313|EMBL:KJS43432.1};
RA   Bagnoud A., Chourey K., Hettich R.L., de Bruijn I., Andersson A.F.,
RA   Leupin O.X., Schwyn B., Bernier-Latmani R.;
RT   "Microbial metabolic network in the subsurface.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJS43432.1}.
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DR   EMBL; LADY01000032; KJS43432.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F2S1X4; -.
DR   PATRIC; fig|1629709.5.peg.4390; -.
DR   Proteomes; UP000033676; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR13847:SF187; DIMETHYLGLYCINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
PE   3: Inferred from homology;
FT   DOMAIN          9..377
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          380..428
FT                   /note="FAD dependent oxidoreductase central"
FT                   /evidence="ECO:0000259|Pfam:PF16350"
FT   DOMAIN          436..700
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          726..800
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   814 AA;  90428 MW;  82C8A703840093E1 CRC64;
     MAEFPGTARV VIIGGGVVGA SCLYHLAKAG WADCVLLEKN ELTAGSTWHA AGNVPTFSTS
     WSVMNMQRYS TELYARLGAE VEYPMNYHQT GSIRLAHSRE RMQEFQRARG MGKVQGMDLD
     ILGVDEIKAR YPFLETHDLQ GALYDPNDGD IDPAQVTQAL AKGARDMGAQ ILRFTPATGV
     RRENGEWIVA TEKGEIRCEY VVNAAGYYAQ RVGEWFKPYG GRTVPMMVMS HQYLLTDEIP
     ELEAWSREAG HKLPLLRDVD SSYYLRQEKY GLNLGPYERN CKAHWVKPDD PMPEDFSFQL
     YPDDLERLEW YIEDAMARVP LLGQAGISKV INGPIPYAPD GLPLIGPMPG VPNAFEACVF
     TFGIAQGGGA GKVLAEWVTE GATEWDMWAC DPRRFTDYTD AEYCVAKGME VYGHEYAMHF
     PWHRWPAAPD RKVSPVHERV KALGGVMGVY NGWERANWFA KPGDDTSEAA TQTWDRAGPW
     EARIREECEA VRDACGVLDL PGFTRLWIEG TGADDWLRGF VTGGLPKVGR MNLVYVADKR
     GRIVTEFSCI RLKEDSFVLI TAATAQWHDG ELVRRALPEG LSLRETTTER DALLLAGPKS
     RDILAGLTDA DLSLPWLSHQ HATVAGQKAF LARVSFTGEL GWEIHAENAA IPTIYEALMA
     AGVKPFGMFA LNSLRIEKGY RAWKGDLSTD YSMLEGGLER FVKFDKPQDF AGKAALLAEK
     QRGVKKRFVT LIVEAKAADA PYMSTLWHEG QIVGETTSGA WGYRVGASVA LGMLRADLAV
     PGTEIEVEIY GERCRAVVQP DAPLWDAENE RLRA
//