ID A0A0F2SDU8_9FIRM Unreviewed; 815 AA.
AC A0A0F2SDU8;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=CRISPR-associated protein {ECO:0000313|EMBL:KJS49058.1};
GN ORFNames=VR66_10625 {ECO:0000313|EMBL:KJS49058.1};
OS Peptococcaceae bacterium BRH_c23.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae.
OX NCBI_TaxID=1629714 {ECO:0000313|EMBL:KJS49058.1, ECO:0000313|Proteomes:UP000033503};
RN [1] {ECO:0000313|EMBL:KJS49058.1, ECO:0000313|Proteomes:UP000033503}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRH_c23 {ECO:0000313|EMBL:KJS49058.1};
RA Bagnoud A., Chourey K., Hettich R.L., de Bruijn I., Andersson A.F.,
RA Leupin O.X., Schwyn B., Bernier-Latmani R.;
RT "Microbial metabolic network in the subsurface.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJS49058.1}.
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DR EMBL; LADV01000124; KJS49058.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F2SDU8; -.
DR PATRIC; fig|1629714.3.peg.1752; -.
DR Proteomes; UP000033503; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 15..208
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 279..457
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 815 AA; 91691 MW; 03454C628A5932FC CRC64;
MHTNSKRFIA HIRAADKHEQ YVDEHNDHVA DLAAAVAQDY GLANIAKLAG RHHDDGKNTP
EFAAYIRAAA EGKKVVRGSV IHSTHGAMLV NELASSKLSS RLTAEMVRMA IMSHHGLRDC
LSLDGDAVFA EAAEKVADSY ESVKKVVYRH YGENSINQEF IEACCDTRSI VASIQALQRK
SKSLGSLQFY LAMFARLLTS LVIDADRTDT ACFEEKRALP RPKAPDERWA MWETYLAHYE
KELEELPKGK KPSSLDPYRG EISRACAEFD GGEAGIFRLV VPCGAGKTLA ALRYALHTAR
HYRKERIFYI APFNSILEQN AAEISRFIGD PAAVLEHHSN IMFNDDESKD KKEEEKRYQL
LTENWAQSPV VATTAVQFLN TLFGGKTSNL RRMQALGNSV IILDEIQALP IKVLKLFNGA
MNFLASFCKT SVVLCSATQP LLDKVDNYRI LPPKSIIADE EKYSEAFRRV QIVDCMTERG
YSREEAADFI AGQLDEARSV LAIVNTKRGA REIFKQIRNR LGDETPYRIF HLSTNMCPAH
RSRVLRQLRA GLEDKESGEK IICISTSLIE AGVDVSFERV VRSLSGLDNI VQAAGRCNRN
YETACGIVSI INLRDEQTGR LGYLKEARQA TQELLYSIKT SPGRYPGGAL SKAAMKEYYA
RYFYSLFAEM AYPLKFDPEH NLLHLLTNNP SGQRGFAEKY PQERLPELKQ AFREAGEAFS
VIEDDGKVDV FIDYDHEAGN RLQKLKAATT LQEKRSALRQ LQPYTVQLRE NDWIQRQRLA
LTPEDAGILV LPPGYYDGEY GVDETLDIKM ETLII
//
