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Database: UniProt
Entry: A0A0F3QG74_ORITS
LinkDB: A0A0F3QG74_ORITS
Original site: A0A0F3QG74_ORITS 
ID   A0A0F3QG74_ORITS        Unreviewed;       468 AA.
AC   A0A0F3QG74;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-SEP-2017, entry version 19.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=OTSUT76_0897 {ECO:0000313|EMBL:KJV91277.1};
OS   Orientia tsutsugamushi str. UT76.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Orientia.
OX   NCBI_TaxID=682184 {ECO:0000313|EMBL:KJV91277.1, ECO:0000313|Proteomes:UP000033364};
RN   [1] {ECO:0000313|EMBL:KJV91277.1, ECO:0000313|Proteomes:UP000033364}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UT76 {ECO:0000313|EMBL:KJV91277.1,
RC   ECO:0000313|Proteomes:UP000033364};
RA   Daugherty S.C., Su Q., Abolude K., Beier-Sexton M., Carlyon J.A.,
RA   Carter R., Day N.P., Dumler S.J., Dyachenko V., Godinez A.,
RA   Kurtti T.J., Lichay M., Mullins K.E., Ott S., Pappas-Brown V.,
RA   Paris D.H., Patel P., Richards A.L., Sadzewicz L., Sears K.,
RA   Seidman D., Sengamalay N., Stenos J., Tallon L.J., Vincent G.,
RA   Fraser C.M., Munderloh U., Dunning-Hotopp J.C.;
RT   "Genome Sequencing of Rickettsiales.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KJV91277.1}.
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DR   EMBL; LANZ01000021; KJV91277.1; -; Genomic_DNA.
DR   EnsemblBacteria; KJV91277; KJV91277; OTSUT76_0897.
DR   PATRIC; fig|682184.3.peg.1854; -.
DR   Proteomes; UP000033364; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000033364};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033364}.
FT   DOMAIN      165    293       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      376    445       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     173    180       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   468 AA;  53576 MW;  26839BCC8EE7E0F0 CRC64;
     MNTLLQQQNT TKDGLYFHEL WSNVKRDLRH HYGEAVFKSW FSKMNMVDFT DGYIKLSAPT
     NFTRDWIKAN YFDSIRQLLA YYDSSITSID IVTCAVDYQS PDLAFSTQQN TDNNQQYSTK
     SSNNVIFSST LDPRFTFDNF VVGRPNELAY AAATTVAESP TAVAKSNPLF LYGGVGLGKT
     HLMHAIAWHI QNSSSKRKVI YMSAEKFMYQ FVQSLRNKDV MSFKEQFRSV DVLMIDDIQF
     ICGKDSTQEE FFHTFNALID NKRQMVISCD RSPSDLDNIE ERIKSRLGWG LVADVHSTTY
     ELRLGILQSK VEQLATSVPL KVLEFLAAKI TSNVRELEGA LNKVIAHSTL VGYEITIENT
     QEILRDLLRS NQKTITIDSI QKKVAERYNI KISDMSSSRR SRSVTKPRQL AMYLAKRLTS
     KSLVDIGKAF GKKDHTTVMH AIKTVEDLSK QEQEFEDEVR LLMRILQN
//
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