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Database: UniProt
Entry: A0A0F3QZI9_ORITS
LinkDB: A0A0F3QZI9_ORITS
Original site: A0A0F3QZI9_ORITS 
ID   A0A0F3QZI9_ORITS        Unreviewed;       469 AA.
AC   A0A0F3QZI9;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=OTSUT76_0454 {ECO:0000313|EMBL:KJV96864.1};
OS   Orientia tsutsugamushi str. UT76.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Orientia.
OX   NCBI_TaxID=682184 {ECO:0000313|EMBL:KJV96864.1, ECO:0000313|Proteomes:UP000033364};
RN   [1] {ECO:0000313|EMBL:KJV96864.1, ECO:0000313|Proteomes:UP000033364}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UT76 {ECO:0000313|EMBL:KJV96864.1,
RC   ECO:0000313|Proteomes:UP000033364};
RA   Daugherty S.C., Su Q., Abolude K., Beier-Sexton M., Carlyon J.A.,
RA   Carter R., Day N.P., Dumler S.J., Dyachenko V., Godinez A.,
RA   Kurtti T.J., Lichay M., Mullins K.E., Ott S., Pappas-Brown V.,
RA   Paris D.H., Patel P., Richards A.L., Sadzewicz L., Sears K.,
RA   Seidman D., Sengamalay N., Stenos J., Tallon L.J., Vincent G.,
RA   Fraser C.M., Munderloh U., Dunning-Hotopp J.C.;
RT   "Genome Sequencing of Rickettsiales.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KJV96864.1}.
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DR   EMBL; LANZ01000008; KJV96864.1; -; Genomic_DNA.
DR   EnsemblBacteria; KJV96864; KJV96864; OTSUT76_0454.
DR   PATRIC; fig|682184.3.peg.4458; -.
DR   Proteomes; UP000033364; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000033364};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033364}.
FT   DOMAIN      166    294       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      377    446       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     174    181       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   469 AA;  53762 MW;  517520A136E953B1 CRC64;
     MNTLLQQPNT TKDELYFHEL WSSVKRDLRH HYGEAVFKSW FSKMNMVDFT DSYIKLSAPT
     NFTRDWIKAN YFDSIRQLLA YYDSSITRVD IVTSAIDHQN SDLAFSTQQN TDNNNQQYST
     KSSNNVIFSS TLDPRFTFDN FVVGRPNELA YAAATTVAES PTAVAKSNPL FLYGGVGLGK
     THLMHAIAWH IQNSSSKRKV IYMSAEKFMY QFVQSLRNKD VMSFKEQFRS VDVLMIDDIQ
     FICGKDSTQE EFFHTFNALI DNKRQMVISC DRSPSDLDNI EERIKSRLGW GLVADVHSTT
     YELRLGILQS KVEQLATAVP LKVLEFLAAK ITSNVRELEG ALNKVIAHST LVGYEITIEN
     TQEILRDLLR SNQKTITIDS IQKKVAERYN IKISDMSSSR RSRSVTKPRQ LAMYLAKRLT
     SKSLVDIGKA FGKKDHTTVM HAIKTVEDLS KQEQEFEDEV RLLMRILQN
//
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