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Database: UniProt
Entry: A0A0F4JTY7_9ACTN
LinkDB: A0A0F4JTY7_9ACTN
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ID   A0A0F4JTY7_9ACTN        Unreviewed;       635 AA.
AC   A0A0F4JTY7;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   05-JUL-2017, entry version 18.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=VR45_07680 {ECO:0000313|EMBL:KJY37832.1};
OS   Streptomyces sp. NRRL S-495.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1609133 {ECO:0000313|EMBL:KJY37832.1, ECO:0000313|Proteomes:UP000033484};
RN   [1] {ECO:0000313|EMBL:KJY37832.1, ECO:0000313|Proteomes:UP000033484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL S-495 {ECO:0000313|EMBL:KJY37832.1,
RC   ECO:0000313|Proteomes:UP000033484};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KJY37832.1}.
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DR   EMBL; JZWY01000104; KJY37832.1; -; Genomic_DNA.
DR   RefSeq; WP_045938904.1; NZ_JZWY01000104.1.
DR   EnsemblBacteria; KJY37832; KJY37832; VR45_07680.
DR   PATRIC; fig|1609133.3.peg.743; -.
DR   Proteomes; UP000033484; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000033484};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033484}.
FT   DOMAIN      328    456       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      543    612       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     336    343       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   635 AA;  70776 MW;  B9E6F1EC8D73E5E6 CRC64;
     MADVNSDLVP VWARVVERLV ADPDIGEMDK QWVQRTQPMW MMHDTALLAA PNERAKQVLE
     GRLLPQLAEA LSRELGRPVR IAVMVDANAM PTMPAPAAQA PVEPYPNPSG HDEHDEHDDR
     RGHDDRHRQD DRQRHDDRQQ RQDERHGQDE GHYGGPGYPR PYESDYDRPR YDNGGYEQRP
     APYGGPAAGP VWPGYQEQQP DYREPDEPMD RRAPRALPPS STTQGDLFGG AYGPGPGEHP
     RTASGRRGPG GRPAQRPTDK AQAERATDRP AVPGVPPPPG APPAGGSRKD EPAARLNPKY
     LFDTFVIGAS NRFAHAAAVA VAEAPAKAYN PLFIYGESGL GKTHLLHAIG HYSRSLFPGT
     RVRYVSSEEF TNEFINSIRD GKADTFRKRY RDMDILLVDD VQFLASKEST QEEFFHTFNT
     LHNANKQIVL SSDRPPKLLT TLEDRLRNRF EWGLITDVTP PELETRIAIL RKKAIQEQLN
     APADVLEFIA SRITRNIREL EGALIRVTAF ANLNRAPVDL ELAGIVLKDL IPGGDEDAGP
     EITAQVIMQQ TAAYFGLGVD DLCGSSRSRV LVTARQIAMY LCRELTDLSL PKIGAQFGGR
     DHTTVMHADR KIRSLMAERR SIYNQVTELT NRIKS
//
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