ID A0A0F4K3B2_9ACTN Unreviewed; 291 AA.
AC A0A0F4K3B2;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=6-phosphogluconate dehydrogenase {ECO:0000313|EMBL:KJY39666.1};
GN ORFNames=VR44_00840 {ECO:0000313|EMBL:KJY39666.1};
OS Streptomyces katrae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68223 {ECO:0000313|EMBL:KJY39666.1, ECO:0000313|Proteomes:UP000033551};
RN [1] {ECO:0000313|EMBL:KJY39666.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL ISP-5550 {ECO:0000313|EMBL:KJY39666.1};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00008419}.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJY39666.1}.
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DR EMBL; JZWV01000012; KJY39666.1; -; Genomic_DNA.
DR RefSeq; WP_045945373.1; NZ_JZWV01000012.1.
DR AlphaFoldDB; A0A0F4K3B2; -.
DR STRING; 68223.GCA_002028425_03557; -.
DR PATRIC; fig|68223.7.peg.2874; -.
DR eggNOG; COG1023; Bacteria.
DR OrthoDB; 9804542at2; -.
DR Proteomes; UP000033551; Unassembled WGS sequence.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
DR GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR004849; 6DGDH_YqeC.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006114; 6PGDH_C.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006183; Pgluconate_DH.
DR NCBIfam; TIGR00872; gnd_rel; 1.
DR PANTHER; PTHR11811; 6-PHOSPHOGLUCONATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11811:SF67; 6-PHOSPHOGLUCONATE DEHYDROGENASE YQEC-RELATED; 1.
DR Pfam; PF00393; 6PGD; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR PRINTS; PR00076; 6PGDHDRGNASE.
DR SMART; SM01350; 6PGD; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Gluconate utilization {ECO:0000256|ARBA:ARBA00023064}.
FT DOMAIN 160..291
FT /note="6-phosphogluconate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01350"
FT ACT_SITE 164
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 291 AA; 31568 MW; 3D610DC6A3018FFF CRC64;
MELGLVGLGK MGGNMRERIR RAGHTVIGYD RNPDLADVHS LRELVDSLQA PRVVWVMVPA
GAATQSTVDE LAELLSPGDI VVDGGNSRWT DDEKHAKELE AKGIGFVDCG VSGGVWGLEN
GYALMYGGDE KHVAAVQPVF DALKPEGDFG AVHAGKVGAG HFAKMVHNGI EYAMMQAYAE
GWELLEKVDS VTDVREVFRS WQEGTVIRSW LLDLAVNALD EDEHLDQLKG FAQDSGEGRW
TVEAAIDNAV PLPAITASLF ARFASRQDDS PQMKMIAALR NQFGGHAVEK K
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