ID   A0A0F4QLY4_9GAMM        Unreviewed;       659 AA.
AC   A0A0F4QLY4;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=TW77_14830 {ECO:0000313|EMBL:KJZ07657.1};
OS   Pseudoalteromonas rubra.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=43658 {ECO:0000313|EMBL:KJZ07657.1, ECO:0000313|Proteomes:UP000033452};
RN   [1] {ECO:0000313|EMBL:KJZ07657.1, ECO:0000313|Proteomes:UP000033452}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2471 {ECO:0000313|EMBL:KJZ07657.1,
RC   ECO:0000313|Proteomes:UP000033452};
RX   PubMed=25879706; DOI=10.1186/s12864-015-1365-z;
RA   Machado H., Sonnenschein E.C., Melchiorsen J., Gram L.;
RT   "Genome mining reveals unlocked bioactive potential of marine Gram-negative
RT   bacteria.";
RL   BMC Genomics 16:158-158(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJZ07657.1}.
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DR   EMBL; JXYA01000033; KJZ07657.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F4QLY4; -.
DR   PATRIC; fig|43658.5.peg.3139; -.
DR   OrthoDB; 5298826at2; -.
DR   Proteomes; UP000033452; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF63; DNA HELICASE IV; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000033452}.
FT   DOMAIN          184..485
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         205..212
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   659 AA;  74185 MW;  5A8E4A6D8EC40767 CRC64;
     MHFSAHFISR VFHSVKSVEI GASGIKIMRS GGEELLTWAQ QCRPPVVVVD WLGTRLAYHD
     GTRVLTVRLK KSLSPNMQCQ LETLWINTHK ARLLGAITSI EQLLQHRYLS IRYWATTRSV
     ISELAKYWSG WQSQAALPET IQQAQYTVAE LNAWQEADLA QFREAYVQAQ LSRYASFFDT
     ICGQPLTQAQ RRACVVQDER QLLLAGAGTG KTSVMVAKAA YLLHSQQATA EQVLMLAYGK
     EAAAEMQQRL SHSKVNVECA TFHSLGLEII ARSEGSKPKL SALSQSDTAR AQFIAETLAS
     LCQDPLYQRD LLALLKRQFG ATEDCDKLDL DSHPVQKLVR QFSEALSFYK QALFLGKVQS
     LSQEFELWNS CFRPVLTDYQ LYLQKEQCID FDDMITRAIE LVRSGQFKSP WHVILVDEFQ
     DISPLRAALL KALLAQNDKY ALFAVGDDWQ AIYRFSGGDI SMTTHFAEHF GEATIQQLDM
     TFRYPQQLLD IASEFVCQNP NQLMKRVNSS KVATCPALIA RPDDDNALST AIDGFMDLTA
     EPCTVLLLAR NHKYLPSEEV LAALSRRFVR ARITALTFHG AKGKEADFCI MLGLHRNSLP
     ARQQSAAIIE ALLPEAESFL DAEERRLFYV ALTRARKQVC LLVPDDPSPF IEQTLTLLD
//