ID A0A0F5VLG1_9ACTN Unreviewed; 326 AA.
AC A0A0F5VLG1;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN ORFNames=TN53_37340 {ECO:0000313|EMBL:KKD03034.1};
OS Streptomyces sp. WM6386.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415558 {ECO:0000313|EMBL:KKD03034.1, ECO:0000313|Proteomes:UP000033641};
RN [1] {ECO:0000313|EMBL:KKD03034.1, ECO:0000313|Proteomes:UP000033641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM6386 {ECO:0000313|EMBL:KKD03034.1,
RC ECO:0000313|Proteomes:UP000033641};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKD03034.1}.
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DR EMBL; JXTE01000099; KKD03034.1; -; Genomic_DNA.
DR RefSeq; WP_046263283.1; NZ_JXTE01000099.1.
DR AlphaFoldDB; A0A0F5VLG1; -.
DR PATRIC; fig|1415558.3.peg.9320; -.
DR OrthoDB; 3733803at2; -.
DR Proteomes; UP000033641; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR45674:SF15; DNA LIGASE (ATP); 1.
DR PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KKD03034.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033641}.
FT DOMAIN 110..233
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 326 AA; 34974 MW; B8E4E8A11500BCA7 CRC64;
MNLPLIPPML ATSGTLPSTT QDAHWAYETK QDGQRVVVYL VGDGSVVLRA RSGEDITAAY
PELGALGATL GTLPAVLDGE ILALDEEGRA DFQLLQSRMG LAHAPGKAAR KAAEVPVHLV
LFDVMHLAGQ SLTALPYVRR RGQLEELGLD GPFWSTPGAI VGHGRQALEA TRDHCLEGLV
CKRLDSVYEP GVRSRAWIKI RNMRSEDVLV GGWLPGKGRL TGLPGAVLVG QRTAGRLRYV
GSVGTGWSES ERTQLAALLG AAATDVCPFD TPPPVAGAHW VLPRLVGEVR YSTRTRAGLL
RQPSWLRLRP DLAPEESAAD LPDDLV
//
