ID A0A0F5VWL5_9ACTN Unreviewed; 1105 AA.
AC A0A0F5VWL5;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Serine protease {ECO:0000313|EMBL:KKD06574.1};
GN ORFNames=TN53_18180 {ECO:0000313|EMBL:KKD06574.1};
OS Streptomyces sp. WM6386.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415558 {ECO:0000313|EMBL:KKD06574.1, ECO:0000313|Proteomes:UP000033641};
RN [1] {ECO:0000313|EMBL:KKD06574.1, ECO:0000313|Proteomes:UP000033641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM6386 {ECO:0000313|EMBL:KKD06574.1,
RC ECO:0000313|Proteomes:UP000033641};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKD06574.1}.
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DR EMBL; JXTE01000026; KKD06574.1; -; Genomic_DNA.
DR RefSeq; WP_046259573.1; NZ_JXTE01000026.1.
DR AlphaFoldDB; A0A0F5VWL5; -.
DR PATRIC; fig|1415558.3.peg.3353; -.
DR OrthoDB; 9813435at2; -.
DR Proteomes; UP000033641; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR InterPro; IPR007280; Peptidase_C_arc/bac.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF04151; PPC; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000033641};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 202..626
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 953..1019
FT /note="Peptidase C-terminal archaeal/bacterial"
FT /evidence="ECO:0000259|Pfam:PF04151"
FT REGION 145..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 211
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 391
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 587
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1105 AA; 113785 MW; 636CF64EBB59C7A8 CRC64;
MTLTPQREPI SGGARRVVRI AVAAGLVAAL SAAGPIPMAV AAADAPAAAD PGVKSAHEKL
GSDDADLLAE AKADGDKNIS MMIATAPGQT EQVAKQLDAV AGGLVGRTFD KVGYVRATVP
TAKADSAIAA AVKLSSVHGI DLRQEIPLDD PTPSADTSKG AAVSKAATPA APGKKTPAEN
PYNPSFETGA VDFVEDHPKA DGRGITIGIL DSGIDLGHPS LQKTTTGERK VVDWVTSTDP
VSDGDLSWRR MLTSVAGPTF SATPAGGAAE TFKAPDGSYK FNYFYESVTA GGDQLGDVNR
DGDTTDAWGV LYDAAAGTMR VDLDDDHDFT DEEALKPYKD GHQIAYFGTD NPATEVSERI
PFVAEIRKDV VYNASGARAD YVNIGMISSE HGTHVAGITA ANSLFGGKMN GAAPGAKLVS
SRACVFGPGC TNIALTEGMI DLVANRGVDI VNMSIGGLPA LNDGNNARAE LYTRLIDTYG
VQLVISAGNS GPGANTIGDP GLADKVISVG ASISKATWYS NYGSAVTKSY AMMPFSSRGP
REDGGFTPTL VAPGAAINTI QTWMPGAPVA EAGYSLPAGY GMLQGTSMAS PQAAGASALL
LSAAKAKGLA LTPQSLRTAL TSTADHIKGV QAYEEGAGLI NIEDAWDSIK DGATAHDYTV
KAPVDTAIDQ FLKTPGFGTG IYDREGGLKA GVKKSYEVTI TRTSGADKAI RHELHLENNA
SGTFSIVGSD EVKLELNKPV TVKIAAKSPT AGLKSAILEV DDPRTEGVDK QILNTVVVST
PLKYTYSASD TVQRNGTQHY FVTVPEGATS LEVAIGGLKG QSQTRFMSIH PYGVSAENSA
FAGTPFCYSN YLDGNGCRPD VRSYPNPTPG VWEIELESRR TSPLLDNPYK LDVTVLGAAF
DPEVVTVPEA KVGTPTAASW KVTNNFAALD GKLVGGPLGS AKSARPTIAD GETQVTTVEV
PEGAKSLDVA IGNVSDAAAD LDLVVLDGNG EEAGTSADGD SEESVSVANP AAGTYTVQVI
GYAIPAGSTA YDYRDVFFSA ALGAVSVDDS AAVKLGTGGT ADVSANVTAL AAAPEGREFF
GQVQLVNARG TVAGIGSVKI EKVTP
//
