ID A0A0F5VXY4_9ACTN Unreviewed; 792 AA.
AC A0A0F5VXY4;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=beta-mannosidase {ECO:0000256|ARBA:ARBA00012754};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
GN ORFNames=TN53_20390 {ECO:0000313|EMBL:KKD06200.1};
OS Streptomyces sp. WM6386.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415558 {ECO:0000313|EMBL:KKD06200.1, ECO:0000313|Proteomes:UP000033641};
RN [1] {ECO:0000313|EMBL:KKD06200.1, ECO:0000313|Proteomes:UP000033641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM6386 {ECO:0000313|EMBL:KKD06200.1,
RC ECO:0000313|Proteomes:UP000033641};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKD06200.1}.
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DR EMBL; JXTE01000031; KKD06200.1; -; Genomic_DNA.
DR RefSeq; WP_046259998.1; NZ_JXTE01000031.1.
DR AlphaFoldDB; A0A0F5VXY4; -.
DR PATRIC; fig|1415558.3.peg.4082; -.
DR OrthoDB; 9758603at2; -.
DR Proteomes; UP000033641; Unassembled WGS sequence.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProt.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000033641}.
FT DOMAIN 234..284
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
SQ SEQUENCE 792 AA; 88805 MW; BC192AD7D970D278 CRC64;
MLQDTPLSEG WILRHEGGEL PAAVPGCVHT DLLAAGVIPD PFLGRNETEV AWVGRREWTY
ETELRAGSGH SAHEQTDLVF EGLDTAAEVR LDGRLLGRTR NMHRSYRFDV TGLEGRLSVR
FASAYAEAEA VRGKLGERPA TYREPFQYIR KMACSFGWDW GPTLVTAGIW RPARLEHWST
ARIARVRPLV TVDVDVESCL GVVELAVEVE RTRVEASLAV RATVGGVRVR ASLDGASGVV
RLEVPDARLW WPRGYGEQPL YDVELTLLHG DDVLDVWRRR VGFRTVELDR SADEHGTGFT
FVVNGERLFA RGVNWIPDDV FPSRITRERY RERLAQAVGA GVDLVRIWGG GIYESADFYD
ACDELGLLVW QDFPFACAAY PEEQPLRGEV EAEARENVVR LMPHPSLVLW NGNNENLWGF
RDWGWEERLA GDSWGEGYYL GVLPRVVAEL DPTRPYTAGS PWSGSWERHP NDPAHGTHHS
WEVWNREDYA EYRREVPRFM AEFGWQAPPA YATLRRALPG EELVPDSPGM LHHQKADDGN
GKLRRGLERH FTYPEADFDR WHYLTQVNQA RAVATGIEHW RSHWPVCAGT VVWQLNDCWP
VTSWAAIDGD GREKPLYHEL RRLYADRLLT VQGRAVAAVN QGPRAWTGAV RLRRMSVEGA
VIGEASVEFT AGARTVALID LPGELEPVGA KEFLVADADG LRALHFPAPD REIPYPRPDF
DVSVAPGSVT VTARSLVRDL LLQADRLDPQ ARADRGLVTL LPGEQVTIGV SGWKTPDPDA
ARSALYCLEP SR
//
