ID A0A0F5W1K6_9ACTN Unreviewed; 470 AA.
AC A0A0F5W1K6;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=RNase H type-1 domain-containing protein {ECO:0000259|PROSITE:PS50879};
GN ORFNames=TN53_09015 {ECO:0000313|EMBL:KKD08364.1};
OS Streptomyces sp. WM6386.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415558 {ECO:0000313|EMBL:KKD08364.1, ECO:0000313|Proteomes:UP000033641};
RN [1] {ECO:0000313|EMBL:KKD08364.1, ECO:0000313|Proteomes:UP000033641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM6386 {ECO:0000313|EMBL:KKD08364.1,
RC ECO:0000313|Proteomes:UP000033641};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKD08364.1}.
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DR EMBL; JXTE01000010; KKD08364.1; -; Genomic_DNA.
DR RefSeq; WP_046257892.1; NZ_JXTE01000010.1.
DR AlphaFoldDB; A0A0F5W1K6; -.
DR PATRIC; fig|1415558.3.peg.397; -.
DR OrthoDB; 5296884at2; -.
DR Proteomes; UP000033641; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR014636; RNaseH/PGlycerate_mutase.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR48100; BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED; 1.
DR PANTHER; PTHR48100:SF1; PHOSPHOGLYCERATE MUTASE PMU1-RELATED; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR PIRSF; PIRSF036922; RNaseH_PGAM; 1.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000033641}.
FT DOMAIN 1..136
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 273
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 349
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 325
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 470 AA; 48342 MW; 3DD76119E2F2548E CRC64;
MREFIVEADG GSRGNPGPAG YGSVVIDAAT GETLMERAEF IGVATNNVAE YRGLLAGLRA
AHELDPAASV HVRMDSKLVV EQMSGRWKIK HPDMKPLAME AGRVYPADQV TYEWIPRESN
KHADRLANEA MDAGKRGEQW TASASTAELD AAASSSRRGA VEFSGGGAAE AGAGVVAGAA
GDAVAGAAKV RAALGSASAG ASRSASSASS ASSASSASSA SSPGGSSRRG AVEFSGGGAA
AAEADVRAAK VVASPGWAPA DMGAPATFVL LRHGETPLTP QKRFSGSGGT DPSLSDVGRE
QAERVAAALA RRGTVQEILA SPLTRTRETA AAVAERLGLE VTVEDGLRET DFGAWEGLTF
AEVRERYPDD LNTWLSDPDA EPTGGGESFA ATATRIAATR DKLVAAYAGR TVLLVTHVTP
IKTFVRLALG APPESLFRME LSAASLSAVA YYADGNASVR LFNDTSHLRP
//
