ID A0A0F6TAB0_9CORY Unreviewed; 599 AA.
AC A0A0F6TAB0;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Choline dehydrogenase {ECO:0000256|RuleBase:RU003969};
DE EC=1.1.99.1 {ECO:0000256|RuleBase:RU003969};
GN Name=betA {ECO:0000313|EMBL:AKE38086.1};
GN ORFNames=UL81_00465 {ECO:0000313|EMBL:AKE38086.1};
OS Corynebacterium camporealensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=161896 {ECO:0000313|EMBL:AKE38086.1, ECO:0000313|Proteomes:UP000033566};
RN [1] {ECO:0000313|EMBL:AKE38086.1, ECO:0000313|Proteomes:UP000033566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44610 {ECO:0000313|EMBL:AKE38086.1,
RC ECO:0000313|Proteomes:UP000033566};
RX PubMed=26021938;
RA Ruckert C., Albersmeier A., Winkler A., Tauch A.;
RT "Complete Genome Sequence of Corynebacterium camporealensis DSM 44610,
RT Isolated from the Milk of a Manchega Sheep with Subclinical Mastitis.";
RL Genome Announc. 3:e00572-15(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=A + choline = AH2 + betaine aldehyde; Xref=Rhea:RHEA:17433,
CC ChEBI:CHEBI:13193, ChEBI:CHEBI:15354, ChEBI:CHEBI:15710,
CC ChEBI:CHEBI:17499; EC=1.1.99.1;
CC Evidence={ECO:0000256|RuleBase:RU003969};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway; betaine aldehyde from choline (cytochrome c reductase
CC route): step 1/1. {ECO:0000256|RuleBase:RU003969}.
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|RuleBase:RU003968}.
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DR EMBL; CP011311; AKE38086.1; -; Genomic_DNA.
DR RefSeq; WP_046453128.1; NZ_CP011311.1.
DR AlphaFoldDB; A0A0F6TAB0; -.
DR KEGG; ccj:UL81_00465; -.
DR PATRIC; fig|161896.4.peg.92; -.
DR HOGENOM; CLU_002865_7_1_11; -.
DR UniPathway; UPA00529; UER00385.
DR Proteomes; UP000033566; Chromosome.
DR GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR011533; BetA.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR NCBIfam; TIGR01810; betA; 1.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00623; GMC_OXRED_1; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003968};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003968};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AKE38086.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033566}.
FT DOMAIN 108..131
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00623"
FT DOMAIN 282..296
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
SQ SEQUENCE 599 AA; 67225 MW; 78304D78CC5B240B CRC64;
MGVFDAVAQK VEKLTSGKKQ HKNVTDEVSD VVVVGGGSAG SVVAARLTEN PDTRVLVLEA
GRPDSIWDLF IHMPSAFSFP IGAKNYDWMY ESEPEPEMNG RRVYHARGKL LGGSSSVNGM
IFQRGNPMDY EKWGDNPGME HWDFAHCLPY FKKMETAAGS DESDPRRGHD GPLYLSRGPA
ISPLFQALFK SVQEAGYNLT NDVNGYRQEG FAPFDRNIKH GRRWSAARAY LHPNLDRKNL
DIRTRALTTK VLFDGQKAIG VEYEWEGETR RVFADKIVLS AGAINTPQLL QVSGIGDEEL
LRKHGIDVVK HLPGVGENLQ DHLEVYIQYE TTKSTDSSQP YLEKWRWPFM GLQWLLTHRG
PVATSHFEGG GFVRSNENEA YPNLMFHFLP MAVRYDGNKA DVKHGFQWHV GPMFSDTKGH
VRIKSADIHD KPEILFNYLR TDQDRREWVE AIRVARSLLD TEAMEEVGAR EFSPGSDVQT
DEEILEWVRN DGETALHPSC TTKMGTKDDP MAVVDPETMQ VWGIEGLYIA DAGVFPSVPN
GNIYAPVMMV GEKAADLIAG KSPLEPEYTS WYKAGEDMPL YAEGETVRDH KHAIKGADY
//