ID A0A0F6TE71_9CORY Unreviewed; 306 AA.
AC A0A0F6TE71;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:AKE42219.1};
GN ORFNames=UL82_10425 {ECO:0000313|EMBL:AKE42219.1};
OS Corynebacterium kutscheri.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=35755 {ECO:0000313|EMBL:AKE42219.1, ECO:0000313|Proteomes:UP000033457};
RN [1] {ECO:0000313|EMBL:AKE42219.1, ECO:0000313|Proteomes:UP000033457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20755 {ECO:0000313|EMBL:AKE42219.1,
RC ECO:0000313|Proteomes:UP000033457};
RX PubMed=26021937;
RA Ruckert C., Albersmeier A., Winkler A., Tauch A.;
RT "Complete Genome Sequence of Corynebacterium kutscheri DSM 20755, a
RT Corynebacterial Type Strain with Remarkably Low G+C Content of Chromosomal
RT DNA.";
RL Genome Announc. 3:e00571-15(2015).
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; CP011312; AKE42219.1; -; Genomic_DNA.
DR RefSeq; WP_046440870.1; NZ_LR134381.1.
DR AlphaFoldDB; A0A0F6TE71; -.
DR STRING; 35755.UL82_10425; -.
DR KEGG; cku:UL82_10425; -.
DR HOGENOM; CLU_035117_1_2_11; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000033457; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000033457}.
FT DOMAIN 3..160
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 164..287
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 306 AA; 30934 MW; 180DFD6C2748B0F5 CRC64;
MIITVVGLGA MGLPMATNLA KTFSVRGVDI AEDRCALAQA AGIETFSSAR EAARESDVVL
LAVRNEPQLL EVLFGTEGIA EVMPAGAVVL LTSTVGMTAV EQAAALLAEK NLGLVDAPIS
GGPVRAGEGD LLVTAGGKPK VVESIREVLE AMASNLVIVG DAPGKGQALK TVNQLLCGVH
IAAAGEALAL ADRLGLDPAA ALDALMSGAA ASFMLGDRGQ RMLEAYTPEG AEVKSRLDIF
VKDMGIVTAA AKKAGIGVPL AAAAEQQYLA GLVRGKAAQD DSSIITVVAP TQLADTVDDT
AQGGKP
//
