ID A0A0F7FH57_9CREN Unreviewed; 836 AA.
AC A0A0F7FH57;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=4Fe-4S Mo/W bis-MGD-type domain-containing protein {ECO:0000259|PROSITE:PS51669};
GN ORFNames=MA03_03940 {ECO:0000313|EMBL:AKG38605.1};
OS Infirmifilum uzonense.
OC Archaea; Thermoproteota; Thermoprotei; Thermofilales; Thermofilaceae;
OC Infirmifilum.
OX NCBI_TaxID=1550241 {ECO:0000313|EMBL:AKG38605.1, ECO:0000313|Proteomes:UP000067434};
RN [1] {ECO:0000313|EMBL:AKG38605.1, ECO:0000313|Proteomes:UP000067434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1807-2 {ECO:0000313|EMBL:AKG38605.1,
RC ECO:0000313|Proteomes:UP000067434};
RX PubMed=26664700; DOI=10.1186/s40793-015-0105-y;
RA Toshchakov S.V., Korzhenkov A.A., Samarov N.I., Mazunin I.O., Mozhey O.I.,
RA Shmyr I.S., Derbikova K.S., Taranov E.A., Dominova I.N.,
RA Bonch-Osmolovskaya E.A., Patrushev M.V., Podosokorskaya O.A.,
RA Kublanov I.V.;
RT "Complete genome sequence of and proposal of Thermofilum uzonense sp. nov.
RT a novel hyperthermophilic crenarchaeon and emended description of the genus
RT Thermofilum.";
RL Stand. Genomic Sci. 10:122-122(2015).
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP009961; AKG38605.1; -; Genomic_DNA.
DR RefSeq; WP_052884031.1; NZ_CP009961.1.
DR AlphaFoldDB; A0A0F7FH57; -.
DR STRING; 1550241.MA03_03940; -.
DR GeneID; 25401353; -.
DR KEGG; thf:MA03_03940; -.
DR PATRIC; fig|1550241.5.peg.839; -.
DR HOGENOM; CLU_000422_13_3_2; -.
DR OrthoDB; 23466at2157; -.
DR Proteomes; UP000067434; Chromosome.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 2.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR006311; TAT_signal.
DR InterPro; IPR019546; TAT_signal_bac_arc.
DR NCBIfam; TIGR01409; TAT_signal_seq; 1.
DR PANTHER; PTHR43742:SF9; TETRATHIONATE REDUCTASE SUBUNIT A; 1.
DR PANTHER; PTHR43742; TRIMETHYLAMINE-N-OXIDE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000067434};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 45..101
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 836 AA; 91374 MW; D712D0726D257F75 CRC64;
MNTPLSRRDF IKAAGLAGLT VAASSPTLRL LRPSQPQTEL QAEQEKIVPN ICMMCPAACQ
ILVRVKDGKI VKIEGNPKGP TNLGKICARG QAGLFRVYNP DRLKKPLLRD NPAQRGTFQG
FREASWDQAF EAVASQVKKL ISEGRVKEIF MLGGWPTCLY LEPYMKAFAD TIGTPNAIGI
PGGACYFPKA FGWSTALGVG AHSQILTDYE NVKYLIVIRR NFFGSLSVVH GTRAGRKLGN
YKLVVVDPRF SETAAKADVW IPIKPGTDLA FLLALIHVVI KEGLYDAEFL RKFTNAPMLV
AEDGSPLTAG TEGGKTKYLV WDLAQGKPVK HEEAILPALE GEYNLDGKKV KPVFQLLKEK
VEAYTPEWAE SITGVPAATI RSIGIEFGKT RPAAVDTGWH DPKYKNSVMT WRAAAILNAL
VGGLVKDGIL ITGAGSIATP PPDVSEESVM RIWGTKQGVA MASKGFTFQG FLDAILNGDP
YKVSMLFMFS TNIALTGPDA TKWREAMKKL EKVVAIDIYP VDAVLYADIV LPESTFLERD
DPLYAIAYAP ALGFQTRVAA VQPVYDTKHL VDIIVGILRK LGDDYYTKFW VNLAKALGAA
DPNAMAAKLK DAYEKNGVRG IRAVQASARN LDPAKLESDG LIVLKDSSTL RKEMINKALA
GQLLTPTGRI EIFSFALNNI KAKKGYQPYW DPIVAWAEPE VLGKADGRQT FYLTYGRVPT
MTHTSTADEP LLSVLTPDYK RMAWINRKVA ESLGIKKGDK IKLVSIANGV SVEAVAFPTD
LVREDTIWVS SDFGHTSEAL HYTKFGVPYH FLTSVKADPV AGGVMSQEVI VKVEKA
//
