ID A0A0F7FTR0_9ACTN Unreviewed; 1232 AA.
AC A0A0F7FTR0;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Malonyl CoA-acyl carrier protein transacylase {ECO:0000313|EMBL:AKG43795.1};
GN ORFNames=SXIM_24110 {ECO:0000313|EMBL:AKG43795.1};
OS Streptomyces xiamenensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=408015 {ECO:0000313|EMBL:AKG43795.1, ECO:0000313|Proteomes:UP000034034};
RN [1] {ECO:0000313|Proteomes:UP000034034}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCCC 1A01550 {ECO:0000313|Proteomes:UP000034034};
RA Xu J.;
RT "Complete genome sequence of a mangrove-derived Streptomyces xiamenensis.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP009922; AKG43795.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F7FTR0; -.
DR STRING; 408015.SXIM_24110; -.
DR KEGG; sxi:SXIM_24110; -.
DR PATRIC; fig|408015.6.peg.2448; -.
DR HOGENOM; CLU_000022_16_6_11; -.
DR Proteomes; UP000034034; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..428
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 893..968
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 856..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1232 AA; 127999 MW; B584FE002B68E105 CRC64;
MTMDTHEPLA VVGMACRLPG APTVGAYWAA LRAGTEGITR FRIEDLLAAG ADPERVRHPD
FVPAMGVLDG ATDFDWSHFG YSRAEAAGID PQQRVFLEAA ATALDDAALD PTRFPGRIGV
YGGADQVGAD DSPHDGDEMG ELARFIGRER DFLATRVAYK LGLRGPAVTV QTACSTSLTA
VHLAAAALRA GECDAALAGG VAVADRRDRG YRYEPGGILS PDGHCRPFDA DAAGTVPSEG
VGVVVLRRLA DALRDGDRIA AVLMGSAINN DGAEKMGYTA PSVSGQSEVI RHAQRMAGVD
PADLDYIEAH GTATPIGDPV EVQALTDAFG PAGGSDTGWC RLGAVKSNLG HTGSAAGVAG
LIKTVLMLER GELVPTVHYR RPNPLQELET TPFLVADRHQ PWPERGVRLA AVSSFGVGGT
NAHVILGQPP HRPRPAAGRG ARALTLSAAT PGALETTGTQ LAALLREEPD ADLAEVARSL
TERRAHRHRR TVVADSAAEA AELLAAPAAP SSGAATGRPA IAFLFPGHGP LSYAAGASAY
RLLPGFRDHF DALSAHVRAT HGIDLGPVVD ERAAEPGWFS DLTHHHLGLF ALGHALGRQL
LDWGVRPVAM LGNSVGEYAP AALAGLWEPT VAADLVHRRA AAMADTAPGG MAAVHAPYEE
VAARLRPGDE VTVAVLGAGA VVLSGPEEAM DRLLAGDALA GLDVRRLDIR QASHCAAMEP
AAEALAKAVA TAPNAAPGLR FVSNTTGAFA DPGAVRGSDY WSEQLRRPVR LADAVGTLLA
AGCDTFVELG PGTSMLGTVR RHPDWPAGHR TVPMLGREED AARGIPAALG ALWECGVDEV
RQALLDLDLA DGGRATRRSL PGHPFARVSP QAAPEPGPRP AAAPTGARTT PVTGRTRILA
AVEELWCAAL GVPRAAEGDH FFRLGGESLM AVQLLTRVRE RTGIAVPVAE FTAHPTFGTL
LAHAAAQPDP EPEPVTVAPA PGPGPVTVVT LASDGPGLPL FLIADSTGGS LAYRSLAGEL
DGTRPVHALD LDLAPAGGTP GAESVAALAA HHVAALRRVR PTGPYLLGGW SFGAVLAHEA
ARQLVAAGER VNAVVCLDAF VQGRYGLPVG LDPEFLAGQA WVRIGAALGV GAVGAAVRRD
PGLPRVLRAK SRTLAVYRPA PVATRAVVLR AGTDRRQARR LLGRLAPLYA QGVEIHPVPG
DHWSLLTPPH VGVLAQRLRT VLSRVEGSGH DH
//
