ID A0A0F7IIB5_9EURY Unreviewed; 428 AA.
AC A0A0F7IIB5;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Thymidylate synthase {ECO:0000313|EMBL:AKG92587.1};
DE EC=2.1.1.45 {ECO:0000313|EMBL:AKG92587.1};
GN ORFNames=GAH_00052 {ECO:0000313|EMBL:AKG92587.1};
OS Geoglobus ahangari.
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Geoglobus.
OX NCBI_TaxID=113653 {ECO:0000313|EMBL:AKG92587.1, ECO:0000313|Proteomes:UP000034723};
RN [1] {ECO:0000313|EMBL:AKG92587.1, ECO:0000313|Proteomes:UP000034723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=234 {ECO:0000313|EMBL:AKG92587.1,
RC ECO:0000313|Proteomes:UP000034723};
RA Manzella M.P., Holmes D.E., Rocheleau J.M., Chung A., Reguera G.,
RA Kashefi K.;
RT "The complete genome sequence of the hyperthermophilic, obligate iron-
RT reducing archaeon Geoglobus ahangari strain 234T.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP011267; AKG92587.1; -; Genomic_DNA.
DR RefSeq; WP_048094157.1; NZ_CP011267.1.
DR AlphaFoldDB; A0A0F7IIB5; -.
DR STRING; 113653.GAH_00052; -.
DR GeneID; 24802642; -.
DR KEGG; gah:GAH_00052; -.
DR PATRIC; fig|113653.22.peg.52; -.
DR HOGENOM; CLU_643417_0_0_2; -.
DR InParanoid; A0A0F7IIB5; -.
DR OrthoDB; 50118at2157; -.
DR Proteomes; UP000034723; Chromosome.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 2.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 2.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 2.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AKG92587.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000034723};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AKG92587.1}.
FT DOMAIN 56..176
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT DOMAIN 284..415
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 428 AA; 50128 MW; 69E29183E0BDEC13 CRC64;
MLIAKDPEKL QKMLISKILD ENLRIRSKYG LELRGKPELV ILEEPFSDFD PDPSGWRACG
ESYSHRVEEC MESAVEKLKS VPYTRRVSIP IWRPKDHLCD TPPAITEISL LYADDRLHAT
AFVRSMDAVS YFTPNLSFIS HVLEEVGKRV GLEAGSVAML VSIPHVYERD LERVERRRYS
ESFGYHRLGT HIVEDYLSSA WHAVLENIYY HGEVKRTEWG ELFEGQEESK YLHRVFVEVK
NPEENQIHDK APFTKKYGIE YAHDYVIHAG AIDREVRESI LKEGETYTYA ERARYCERDE
VRVDQLYTVI RKLKERRERR DCYVGISRPW DITSDEPPCL RGYQFGVNEN FFGIFYMRSN
DAYGAMHANM YAFNILTKYV AEMLGFSSHR YYHFALDAHI YGEFVDSVRE ILEPETPGYV
DKINRKGY
//
