ID A0A0F7KIP7_9PROT Unreviewed; 828 AA.
AC A0A0F7KIP7;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=DNA polymerase III subunit epsilon {ECO:0000313|EMBL:AKH39351.1};
DE SubName: Full=Nucleoside-diphosphate-sugar epimerase {ECO:0000313|EMBL:TYP86051.1};
GN ORFNames=AAW31_00165 {ECO:0000313|EMBL:AKH39351.1}, BCL69_10348
GN {ECO:0000313|EMBL:TYP86051.1};
OS Nitrosomonas communis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosomonas.
OX NCBI_TaxID=44574 {ECO:0000313|EMBL:AKH39351.1, ECO:0000313|Proteomes:UP000034156};
RN [1] {ECO:0000313|Proteomes:UP000034156}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nm2 {ECO:0000313|Proteomes:UP000034156};
RA Kozlowski J.A., Kits K.D., Stein L.Y.;
RT "Draft genome of Nitrosomonas communis strain Nm2.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AKH39351.1, ECO:0000313|Proteomes:UP000034156}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nm2 {ECO:0000313|EMBL:AKH39351.1,
RC ECO:0000313|Proteomes:UP000034156};
RX PubMed=26769932;
RA Kozlowski J.A., Kits K.D., Stein L.Y.;
RT "Genome Sequence of Nitrosomonas communis Strain Nm2, a Mesophilic Ammonia-
RT Oxidizing Bacterium Isolated from Mediterranean Soil.";
RL Genome Announc. 4:0-0(2016).
RN [3] {ECO:0000313|EMBL:TYP86051.1, ECO:0000313|Proteomes:UP000324176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nm2 {ECO:0000313|EMBL:TYP86051.1,
RC ECO:0000313|Proteomes:UP000324176};
RA Wagner M.;
RT "Active sludge and wastewater microbial communities from Klosterneuburg,
RT Austria.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the VKOR family.
CC {ECO:0000256|ARBA:ARBA00006214}.
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DR EMBL; CP011451; AKH39351.1; -; Genomic_DNA.
DR EMBL; VNHT01000034; TYP86051.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F7KIP7; -.
DR KEGG; nco:AAW31_00165; -.
DR PATRIC; fig|44574.3.peg.40; -.
DR OrthoDB; 9801056at2; -.
DR Proteomes; UP000034156; Chromosome.
DR Proteomes; UP000324176; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR CDD; cd12919; VKOR_2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.20.1440.130; VKOR domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR012932; VKOR.
DR InterPro; IPR038354; VKOR_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF23; BLR5423 PROTEIN; 1.
DR Pfam; PF01370; Epimerase; 1.
DR Pfam; PF07884; VKOR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Quinone {ECO:0000256|ARBA:ARBA00022719};
KW Redox-active center {ECO:0000256|ARBA:ARBA00023284};
KW Reference proteome {ECO:0000313|Proteomes:UP000034156};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 395..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 711..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 746..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 772..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..241
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT DOMAIN 524..658
FT /note="Vitamin K epoxide reductase"
FT /evidence="ECO:0000259|Pfam:PF07884"
SQ SEQUENCE 828 AA; 93221 MW; 1B3F77D7026C8961 CRC64;
MDHQKNMTNL KKPLVIITGA SGNIGGSLCD ALRKDYFVVG LDINPCDKAD ISIDCNLTSE
NSVKSAFNEI RSQYGQKIAA AIHLIAYFDF TGQPNPLYQS VTIEGTQRLL NILQDFEVDR
FIFSSTMLVH EPTVPGQKIN EGMPLKPRWA YPQSKVEAEK VIKQQHNKIP YTILRLAGVY
DNDRAVPTLS HQIARIYERD FRSHLYSGDL MAGQALLHKE DMVDLFKRVV DRRKKLPHTN
IMLAGEDEVM SYQELQNRIG YLIFGKKEWQ TVDIPEFIAK SGAWLEEQAE PIVPDTIDQG
KKPFIKPFMI DLASDHYDID ISRAQKLLHW KPKHRIYEGL KNLIASLKKD PAAWYKRNGV
LLPDWVRTAQ EKDLNADQIR HKHETEYFRQ HNENLWAHFL NLGLAFWLMT APFILAYESQ
AMVWSDVISG VVLLILSFMS LSWRFGLARW LCGAVGLWLL GAPLIFWAPT AAAYLNDTIV
GMLVMGFAIL TRPVPGVAAV AAQTGPTIPP GWSYSPSSWF QRLPIIILAF IGFFISRYLC
AYQLGHIDSV WEPFFAGSPQ DPRNGTEEII TSSISQAWPV PDAGLGAMTY ALEILTGIIG
SARRWRTMPW LVILFGIMIV PLGIVSIFFI IIQPILIGTW CTLCLIAAVA MLIQIPYSID
ELVATGQFLS RRKKQGRSLI HVFFQGDTDE GRREVIEDNF AQRPSKIFKE ILGGGVTLPW
NLVMCLPIGI WLMFTRITLD AGTSMANADH LIGSLVLTVA ITALAESGRA SRFFLIPLGL
ALLVTPFFYD TSIESLISSI FCGLLLIIFS LPRGSVHNRY GTWDRFIV
//
