ID A0A0F7NCX7_9ACTN Unreviewed; 4611 AA.
AC A0A0F7NCX7;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Amino acid adenylation protein {ECO:0000313|EMBL:AKH86061.1};
GN ORFNames=AA958_31920 {ECO:0000313|EMBL:AKH86061.1};
OS Streptomyces sp. CNQ-509.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=444103 {ECO:0000313|EMBL:AKH86061.1, ECO:0000313|Proteomes:UP000034283};
RN [1] {ECO:0000313|EMBL:AKH86061.1, ECO:0000313|Proteomes:UP000034283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNQ-509 {ECO:0000313|EMBL:AKH86061.1,
RC ECO:0000313|Proteomes:UP000034283};
RA Ruckert C., Albersmeier A., Leipoldt F., Winkler A., Zeyhle P.,
RA Kalinowski J., Heide L., Kaysser L.;
RT "Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer
RT of Meroterpenoid Chemistry.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP011492; AKH86061.1; -; Genomic_DNA.
DR RefSeq; WP_047019289.1; NZ_CP011492.1.
DR STRING; 444103.AA958_31920; -.
DR KEGG; strc:AA958_31920; -.
DR PATRIC; fig|444103.5.peg.6741; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000034283; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19543; DCL_NRPS; 3.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000034283}.
FT DOMAIN 961..1035
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2496..2570
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4027..4101
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2478..2497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4611 AA; 484219 MW; 0E6E4C996E1D9CE9 CRC64;
MTRSAVEDVW PLSPLQEGLL FHAAFDEEGP DVYQGQRLLE LAGPVDPERL RASWEALLQR
HAALRASFRR RKSGEAVQVI ARDVTLPWEV ADVSDRPEAD ALAEAGRLAA RARAERFDPA
AAPLLRLLLV RLGAERYRLV VTSHHLLMDG WSMPVLLGEL SAVYAAGGDA RGLPPVTSYR
EYLAWLRRQD KDAARAAWRA ELAGADEPTL VAPADPGRLP VAPESLIAEI PQELYVGLVA
LARTRGLTLN TVVQGAWAMV LARLAGRTDV VFGATASGRP PELPGVESMV GLFINTLPVR
VRLDGAQPAA DMLAALQDRQ SALVVHQHLG LPEVQRISGS GGVFDTIVVY ENYPLPPEGA
PDPGMFALRM AGGQEAAHYP LTLVAAPGEQ MSFKLDYRPD LFDRAAARTV FERLVRVLEQ
IAADPAAPVG RIDMIAAADR ARVVGEWNAT GAPLPAASVP ELFAAHAVRS PDAPAVSDGP
RTLSYGELDA ASARLAAHLT AAGVRRGNRV AVVMERSADL LVVLLGVWKA GAAYVPVDPG
YPAERVAFLL ADSAPAAVVC TRETRAAVPG DAAAVLVVLD DPPTAAALAD RPTAAPVPVG
ATDVAYVMYT SGSTGTPKGV AVPHGAVVVL AGESGWEAGP GEAVLMHAPH AFDISLYEVW
VPLAAGGRVV IAEPGAVDAE RVRRAVAGAG VSRLHVTAGL FRVLAEESPE CFTGLREVLT
GGDVVSGAAV ARVREACPGL SVRHLYGPTE ITLCATWHAL RPGDTAGAVL PVGRPMANRR
VYVLDAFLQP VPPGVVGELY VAGPGLARGY LGRAVLTAER FVSCPFDPGG RMYRTGDLAC
WTDEGLLHFA GRADEQVKIR GYRVELGEVE SVLAVHEDVA QAVVVAREDR PGEKRLIGYV
VPDGRPVEAE QLRGHVAAVL PEYMVPAAVV VLDELPLTVN GKVDWAALPA PGFAGRATGR
VPAGAAEEAL CALFAEVLGL ERVGADDDFF ALGGDSITSM QLASRARRAG YVLTPRQIFE
EKTPERLALV AGSARRRSPV RDDGVGDVPW TPVMRRLGLR AAAPGFAQWT VAGAPAGLGL
AALTGGLGAV LDAHDMLRAR TDLADAAHPR LTVGKRGSVD PAALVTRIDA SDGDDLDDTG
GGGLDALAER EARAAAGRLD PAAGTMVQVV WLDAGPARIG RIVLVLHHLV VDGVSWRILL
PDLRAACEAV GEGRKPELEP VGTSFRRWSR ELAAQAGQPE RAAEAAAWAA LLGAPEPPLG
TRALEPARDT AATLRSRTWT VPAGQAETLT GHTPVVFHTG VHEVLLATLA GAVARWRPGA
YDELLVDIEG HGREPAGDAD LARTVGWFTS VRPVRASVSG IDLDGVRAGG AAAGALLKAV
KEQARAVPGD GLGYELLRYL NPGTADAMAA LPQPQIGFNY LGRFAAGGPS GPVGAWQLAG
DTAVGGSVDP GLPLAHALEA SAAVRDTAAG PELTITLSWA GGLLADADAE RLGAVWLEML
AGLAAHTEDP AAGGHTPSDF PLLALTQEAV EELEAAVPAP ADIWPLSPLQ EGMLFHATYD
DDSRDVYKSQ RVLALDGPLD TRRLRAAWET VLARHTALRA SFHRLAASGE AVQVVERDVP
LPWRTVDLSG TDSGVVSEEV ARLAAEELRQ PMDLGRAPLL RFLLIRLGDR AHRMVITSHH
ILADGWSMPV VFNEVSEVYA AGGTDSGRTP AASYGDYLAW LGRQDKEAAR EAWRAELAGV
DEPTLVVPAD PGREPVVPEE CLVGLTDETT AALGVWARER GLTVNTVVQG AWALVLARLA
GRSDVVFGAT VAGRPAELPG VESMVGLFIN TLPVRVRLDG GQRVVDLLAD VQRRQSALTG
HQHLGLQEIQ ELAGAGATFD TMLMFENYPR NDLELPGTGP ADDAIGITQV RSMAGTHYPL
AIGVVPADRL HVRVTYRPDL FGAGEAEGLA RRLVRVLEGV VADPSVRVGD VEVLDARERT
AVVSGWNATE LAVPSGLVLD RFEARVRRAP EAVAVRCGAE ALSYGELDAR ANRLARYVRR
LGVGRESRVG LCLPRGVEMV AGMLAVWKAG GAYVPLDPGY PAERLGFMIA DSGAAVVVGA
AGSLAEVPTG AARVVLLDEA SAEIAAESVE PLQSALEPGQ LAYVIYTSGS TGRPKGVAVP
HMGPANLAEV MCPVLGVAEG VTALQFASFS FDAAVLDVVV TLAAGGTLAI ASGEEREEPA
ALAEMIRNVG VSVASVVPSL LSVLDPAAVR GVRNWVLGAE LLTADLASRW TGQARVWNTY
GPTEATVITS ATLLDADIEP HDAPPSIGRP IGNARTYVLD DFLRPVPPGV VGELYIAGPG
LARGYIGRGG LTGERFVACP FEPGARMYRS GDLARWSSDG LLHFAGRADE QVKIRGFRIE
PGEIEAVLAA HPEVAHTAVV VREDQPGDKR LVGYVVPVGG RVEPDAVREF AAARLPEHMI
PAAIVALDAL PLTPNGKTDR AALPAPDLAE RASGRAPEGA TEETLCALFA DVLSLQRVGA
DDDFFALGGD SITSMQLASR ARREGLVLTP RQVFEQRTPE RLAVVVGAAR TALPAPARAR
DTGEVPWTPA MRAQGVRAAD ADFAQWMVVG APASLTRPVL TGGLAALLDA HAMLRARADV
SDPANPRLVV PERGTVDPAR LVTRIDAAGT TDLDALAARE ARTAAAQLRP EDGSMADVVW
LDAGPSRVGR LVLVAHHLVV DGMSWRILLP DLQSACTALA DNRQPTLDPV PTPFRHWAHA
LVTQAASTHR TDELQPWTDL LATPEPPLGH RPLDPTTDTA ATQRRREWTV PAAQAALVAG
RVPAAFHTGV HEVLLATLAG AVVHWRPDTT DNGVLVDIEG HGRESEGDVD LSRTVGWFTS
SHPVRVDVSG ARLDDALAGG AAAGSLLKSV KEQVRAIPGD GLGHDLLRHL NPETADAMAA
LPRPQIGFNY LGRFPAPAPA SSVRAWQPAG DTALGGSVAP DMPVAHALEA GAVVQDGPDG
PELTLTLSWA GGLLDDADAD RLGATWLRMI AGLATHAAHP AAGGHTPSDF PLLALTQDAV
AELETAVPAL ADVWPLSPLQ QGLLFHADFD DAGPDVYEGR RALALDGPLD TDRLRAAWAT
VLDRHPILRA SFHRLASGEA VQVIARDVPL PWREADLSGL DAAEAARELR RLTEEDRAER
FDLTTAPPLR FLLVRLGEDR HQLLVGNHHI VMDGWSLPLL IGEVSAAYAA AGDGSRLPAV
ASYADYLGWL ARQDEDAARG AWRAELAGAD EPTLVVPAES VRAPVLPERV RYEFGAELSA
GVAELARAHG VTVNTVVQGA WALVLARLAG RDDVVFGATA AGRPPELPGV ESIIGLFLNT
LPVRVRLDGA QRVADMLTGL QERQVALMAH QHIGLQEVQK AAGPGGTFDT LVVFENYPAP
PAGPRDPEAL TIRPAGVTED TGHYPLTLIA VPGERIQGDF IYRPDVFDRD RAEGILASFE
HVLAQLVADP AAPVGRVAAV TEAGRALVTG EWNRTGAPLP AAPLPELFSV QVGRSSGAVA
LVAGGESLSY GELGGRVGRL GRYLVAAGVG PEVRVAVVVE RSALLVEALL AVSLAGGVFV
PVDPGYPPER VVFVLGDADP AVVLCTVATR DVLPEDVRAV VLDDPAVAAE VVAYPGGVLR
AEERRGPLTA DHAAYVIYTS GSTGTPKGVV VSHRGLGNLA RAQIDRFAVG PQSRVLQFAS
ASFDAAVSEL CMALLSGAAL VVPAAGELPP HLSLGEALRA AGATHVTVPP SVPAVTDELP
DTLETLVVAG EACPPGLVGR WSAGRRMVNA YGPTEATVCA TMSVPLTPGT DPVPIGAPMA
NVRAYVLDTF LQPVAPGVTG ELYVAGPGLA RGYRGRPGLT AERFVACPFT PGERMYRTGD
LTRWTGEGEL VFAGRADEQV KVRGHRIEPG EIETALGAHP DVAQAVVAAR QDRPGESRLV
AYVVPSGPYD DGELPSVLRE HVRERLPEYM VPAAVVPLER MPLTPHGKVD RGALPAPDFA
RLVSDREPGT AAEAALCALF AEVLALERVG PDDSFFALGG DSITSMQLAS RARRAGYVLT
PRQIFEEKTP ERLALVVQAA DGAPAVADVG VGEVPWTPVM RRLGEGVAGG RFAQWTVVGA
PADLTADVLA TGLGALLDTH DMLRARTDLS DAAAPRLVVA GRGTYDAAGL VTRTDAVGVP
DDGLDEAASG VAREAVARLD PAAGVMVQAV WLDAGPGRVG RVVLAVHHLV VDGVSWRILL
PDLRAACEAA AAGEEPVLDP VPVSFRRWAR TLVAEAASER RRAEPAQWTA LLGEPEPPLG
HRPLDPAVDT APTLRNRSWT VPADQAATLV GRTPGVFHCG VHEVLLATLA GAVAGWRPGA
HDGVLVDIEG HGREPVGDLD LTRTVGWFTG VHPLRLRTSG IDLDAVRAGG AAAGELLKSV
KEQAQEIPGD GLGHGLLRHL NPETVEVMAA LPQPQIGFNY LGRFPAAGPA GPVRAWQPAG
ETAVGGSAAA GMPVAHALEA GAVVQDGPAG PALTVTLSWV SGLLADADAE RLGAAWLELL
AGLAAHTEDP DAGGHTPSDF PLLDLAQNQI EELEAAFADE QSRPGRPARS R
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