ID   A0A0F7ZIH8_9HYPO        Unreviewed;      1008 AA.
AC   A0A0F7ZIH8;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0000259|Pfam:PF00082};
GN   ORFNames=HIM_06829 {ECO:0000313|EMBL:KJZ73711.1};
OS   Hirsutella minnesotensis 3608.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Hirsutella.
OX   NCBI_TaxID=1043627 {ECO:0000313|EMBL:KJZ73711.1, ECO:0000313|Proteomes:UP000054481};
RN   [1] {ECO:0000313|EMBL:KJZ73711.1, ECO:0000313|Proteomes:UP000054481}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3608 {ECO:0000313|EMBL:KJZ73711.1,
RC   ECO:0000313|Proteomes:UP000054481};
RX   PubMed=25359922; DOI=10.1093/gbe/evu241;
RA   Lai Y., Liu K., Zhang X., Zhang X., Li K., Wang N., Shu C., Wu Y., Wang C.,
RA   Bushley K.E., Xiang M., Liu X.;
RT   "Comparative genomics and transcriptomics analyses reveal divergent
RT   lifestyle features of nematode endoparasitic fungus Hirsutella
RT   minnesotensis.";
RL   Genome Biol. Evol. 6:3077-3093(2014).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01240}.
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DR   EMBL; KQ030532; KJZ73711.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F7ZIH8; -.
DR   OrthoDB; 2247221at2759; -.
DR   Proteomes; UP000054481; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00306; Peptidases_S8_S53; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR   PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000054481};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}.
FT   DOMAIN          686..926
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   REGION          883..903
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        884..903
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        692
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        743
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        906
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   1008 AA;  112141 MW;  0E79AAFB3F29DBC3 CRC64;
     MSCRLDANVV EWRLLTEIQP LFAGPVPWDL AIGDVGAAAA AVAITAEKVK TVFASQMGEM
     RINLIDLARF DLEQQSYSSC RDKIRRLLEL LEEIVLDHVL DDPDGQAVEA SPVEEYRSVC
     PSNPVKKTLT DALRNSICSW LGIQAQDLEN SSTRGTADFQ CLAPDTSKQP FPKLQALARF
     IIKRSGQSPT QTWVASCSAF LKLQLTLVKF EQLKAKATRV NRVIDGLPQR FSQMNSGAPR
     PPNIARTQWE STKAFQLTNC LYRLLRKAIC IRVDEHKTEL QLNGFELDQS CANSSLSQNM
     IVVSCPKADV LDMCHCTFVS QPFPNLTALE DTRDQSTRHY DVPEAILSDL CGLMPHVSSR
     PFKISFDDED LWYSKTRDPS SAGLVAANMV SLEYLLEHGF FSKDREGDVF SLNDKAVLAL
     SLARCLVHLW PGRWVRGPWT TESIKFMCTT NHLLDRHYPY LTCSVTKSDA SEGQDEDRGP
     DHLQLSVLSL AGLLAEIETG LPIQSNLASD TIESFKDEID DAMEPTRNQF GRGYYNTAIQ
     KCLQFMVLLK RGVTYEQGDF QTTARNIFYH NIIKPLEDNF GQIPYPATVM KPQPLNLGRY
     TTESSALPPG INATKLSTSH RNGAAMSSIN LGMERDHQAV MFFDEESTAS SELIDRADFF
     LDAFKRFQRR HIDPKTRQGR GGRRRTRIAV LDTGIDMGNE GIRGLVDEIM NSRRMMKCPK
     ADRNPIREIG SFTGDNGSDD FGHGTLVAGL ILQTAPEADI FVAKVSGAKS FTNMKAVAEA
     IDWAIKREVD IINMSFGCEF DVHSVVLALD RTATVKHPRP ILLAAASNNG RNSQRTFPAR
     HKDVIAIHAL DGKGNDNGGM NPSRRGHHDN FGTLGLGIRS LGDASHSSPD TASARGPQKA
     YKSGTSYATP IAAGIVANCI EWIGYMRDRD HMTAHQYRFL RGPDGIRLML KKQSETVGDI
     LSIAPWILWK EDPLDTVGDG GWPREVTEKA DKDVLVLLLE DMHPIMWD
//