ID   A0A0F7ZQP0_9HYPO        Unreviewed;       911 AA.
AC   A0A0F7ZQP0;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Integrase catalytic domain-containing protein {ECO:0000259|PROSITE:PS50994};
GN   ORFNames=HIM_12410 {ECO:0000313|EMBL:KJZ68198.1};
OS   Hirsutella minnesotensis 3608.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Hirsutella.
OX   NCBI_TaxID=1043627 {ECO:0000313|EMBL:KJZ68198.1, ECO:0000313|Proteomes:UP000054481};
RN   [1] {ECO:0000313|EMBL:KJZ68198.1, ECO:0000313|Proteomes:UP000054481}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3608 {ECO:0000313|EMBL:KJZ68198.1,
RC   ECO:0000313|Proteomes:UP000054481};
RX   PubMed=25359922; DOI=10.1093/gbe/evu241;
RA   Lai Y., Liu K., Zhang X., Zhang X., Li K., Wang N., Shu C., Wu Y., Wang C.,
RA   Bushley K.E., Xiang M., Liu X.;
RT   "Comparative genomics and transcriptomics analyses reveal divergent
RT   lifestyle features of nematode endoparasitic fungus Hirsutella
RT   minnesotensis.";
RL   Genome Biol. Evol. 6:3077-3093(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49;
CC         Evidence={ECO:0000256|ARBA:ARBA00024557};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; KQ030982; KJZ68198.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F7ZQP0; -.
DR   OrthoDB; 2609555at2759; -.
DR   Proteomes; UP000054481; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR025724; GAG-pre-integrase_dom.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR42648; TRANSPOSASE, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR42648:SF11; TRANSPOSON TY4-P GAG-POL POLYPROTEIN; 1.
DR   Pfam; PF13976; gag_pre-integrs; 1.
DR   Pfam; PF14223; Retrotran_gag_2; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054481};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW   Transposition {ECO:0000256|ARBA:ARBA00022578}.
FT   DOMAIN          589..753
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          843..889
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        851..879
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   911 AA;  101632 MW;  D89B0A0207139B3E CRC64;
     MSTSNSSSSS LSMSSVTGIL KLSSQTGWIT WNREIRDLLT VAGYGDLLPG GRKAVQPAQR
     DEESESIFED RLEIWLDRQT RVKAVLCNRL SFLAREDVKH LETAAQILQT IETRYKPSGS
     ACFQELDKKY MDLTLDSCTD VMDFAEKLRQ ARSELLELDV SCQIGEPQFI SKFLTGLGPA
     YEVFLTAFYQ QHNLLPKRDL AGALTRPAVS FEEAIAAAEH EEQSQKQRGT TAGQALAVTQ
     RDRDVPVCTH CKRKGHTVDK CFRVHPELKA DFDMRRAERL KKKQDLRGRQ EPTTPSITDI
     QTALAYLQGQ ANDQPQSQSQ ALANLAMPRF TFSCTIHFAL PGAANPVGVC DGLDPSALAA
     QHALLSQIHI LDTGASQHIF CRRSKFGSLV PYTGLPYTGA QFLPLGTGTY DLPVKVCGKD
     HLLTFQDALC APDAGVNLVS VTALGKEGCW ILGNGEHAAI VKGGQIVLTA TVANGVYVID
     QPNRDINAAL ASLRTQDPDL TLWNEATDEI RRHSNPSAVS SDPAALITSQ VQDSNLRIWH
     ERLAHLSERN IKRLQGMSTG LRPQAPQDPC EACAIGKIKE GPHRHSIRKG TRPLESLHID
     ICGPSPDIGY DSSRYWVAIL DDYTQYGWTF SVVTKDSLFL ILQAFLQKHE TPTSRCLYVR
     MDLGGENRSK LLDAFCIDKA IEVIYAATEQ HQQNGAIEVF YRVLSEKLNP TLIWSGLERK
     WWPYVLQSIT YVRNMSPTAK SPITPYEAWH GEEPDVTHLR VIGSKAWALL PAAKRRKLQP
     KGIPCRMLGY QGHCNYVLLD SNNRVFVSPN VIFVEHIAKP AVSERQPKRS KTGQTLDQLI
     QEEGQQAERP AWTLRNGNAT MQRPRQRRST HQQPPQRSRP SLKMIKPQIP RQTCLTALKT
     TYCPMETTVP C
//