ID A0A0F8D289_LARCR Unreviewed; 870 AA.
AC A0A0F8D289;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Metabotropic glutamate receptor 4 {ECO:0000313|EMBL:KKF33094.1};
GN ORFNames=EH28_02596 {ECO:0000313|EMBL:KKF33094.1};
OS Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Sciaenidae; Larimichthys.
OX NCBI_TaxID=215358 {ECO:0000313|EMBL:KKF33094.1};
RN [1] {ECO:0000313|EMBL:KKF33094.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSNF {ECO:0000313|EMBL:KKF33094.1};
RC TISSUE=Blood {ECO:0000313|EMBL:KKF33094.1};
RX PubMed=25835551;
RA Ao J., Mu Y., Xiang L.X., Fan D., Feng M., Zhang S., Shi Q., Zhu L.Y.,
RA Li T., Ding Y., Nie L., Li Q., Dong W.R., Jiang L., Sun B., Zhang X.,
RA Li M., Zhang H.Q., Xie S., Zhu Y., Jiang X., Wang X., Mu P., Chen W.,
RA Yue Z., Wang Z., Wang J., Shao J.Z., Chen X.;
RT "Genome Sequencing of the Perciform Fish Larimichthys crocea Provides
RT Insights into Molecular and Genetic Mechanisms of Stress Adaptation.";
RL PLoS Genet. 11:E1005118-E1005118(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; KQ040916; KKF33094.1; -; Genomic_DNA.
DR RefSeq; XP_019120986.1; XM_019265441.1.
DR AlphaFoldDB; A0A0F8D289; -.
DR eggNOG; KOG1056; Eukaryota.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001786; GPCR_3_mGluR4.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF23; METABOTROPIC GLUTAMATE RECEPTOR 4; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01054; MTABOTROPC4R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KKF33094.1};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..870
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018322299"
FT TRANSMEM 545..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 545..819
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 870 AA; 96520 MW; F1E68D8799E6A61B CRC64;
MTLRGGFERA WIGSHRSVCC WVLLLACYFL IASAAKPKMP GHTHLNSIRI DGDISLGGLF
PVHARGNDGK ACGELKKEKG IHRLEAMLFA LDRINNDNEL LPNITLGARI LDTCSRDTHA
LEQSLTFVQA LIEKDSTDVK CLSGGPPIIT KPERVVGVIG ASASSVSIMV ANILRLFKIP
QVSYASTAPE LSDNTRYDFF SRVVPPDTYQ AQAMVDIVKA MRWNYVSTVA SEGNYGESGV
DAFIQKSRED GGLCISQSVK IPREPRTGEF DKIIRRLSEN PNARVVIIFA NEDDIRRLLQ
ASKKANQTGH FIWVGSDSWG SKISPILNQE EMAEGAVTIL PKRQSIKDHE RIGKDSSYEQ
EGKVQFVIDA VYAMAHALHN MHKDLCPGKV GLCNKMDTIN GTLLLKYIRN VNFTGIAGTP
VVFNVNGDAP GRYEIYQYQI TNNTTEYKII GHWTDQLHLD TNEMQWPGGN PEVPSSICSQ
PCRPGQRKKT VKGIPCCWHC ENCDGYQYQA DTYTCKMCRF DLRPNENHTG CDPIPIVKLE
WSSPWAVIPV LLAVLGIMAT LFVVVTFVRY NDTPIVKASG RELSYVLLTG IFLCYATTFL
MISSPDVFIC SLRRIFLGLG MSISYAALLT KTNRIYRIFE QGKMSVSAPR FISPASQLVI
TFSLISVQLL GVCIWFGVDP SQAIIDYQDQ RTANPKMARG VLKCDISDLS LICLLGYSML
LMVTCTVYAI KTRGVPETFN EAKPIGFTMY TTCIVWLAFI PIFFGTSQSA EKMYIQTTTL
TISVSLSASV SLGMLYMPKV YVVLFHPEQN VPKRKRSLKA VVTAATMSNK FNPKGGLRPN
GEAKSELCES LETQALASKQ TYISYSNHAI
//
