ID A0A0F9X068_TRIHA Unreviewed; 4833 AA.
AC A0A0F9X068;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=THAR02_09861 {ECO:0000313|EMBL:KKO98034.1};
OS Trichoderma harzianum (Hypocrea lixii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=5544 {ECO:0000313|EMBL:KKO98034.1, ECO:0000313|Proteomes:UP000034112};
RN [1] {ECO:0000313|Proteomes:UP000034112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA Pe M.E., Sarrocco S., Vannacci G.;
RT "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT T6776.";
RL Genome Announc. 3:E0064715-E0064715(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKO98034.1}.
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DR EMBL; JOKZ01000470; KKO98034.1; -; Genomic_DNA.
DR OMA; HHIVTEG; -.
DR OrthoDB; 1778695at2759; -.
DR Proteomes; UP000034112; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00823; PKS_PP; 5.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 6.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000034112}.
FT DOMAIN 527..600
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1588..1665
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2130..2206
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3205..3282
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3733..3809
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4283..4356
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 4806..4833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3674..3701
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 4817..4833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4833 AA; 535544 MW; 8A5CBF6CD133C730 CRC64;
MEAPADLSVL NPHPTLLPGP DLLHHLIRQP DDSIALDYLG RNKRVSFSYR QLHDAADALA
ARICRAFGES RDQFVVPVLV HQSPHLYIAL LAILKAGGAF CPLNVDAPPD RVNFILNDVS
AAVVVASAEL ASRIPPQSAV KVLIAEDEEE PCLDRDSVDC RAPSTRDLAY VMYTSGSTGV
PKGVGISHAA VTQALLAHDQ HVPAFSRFLQ FAAPTFDVSV FEIFFPLFRG STLVSVDRKE
MLNDLPAVIS EMEVDACELT PTVAASLLRK RENNPTLQLL LTIGEMLNEP VIREFGGSQD
RKSLLWAMYG PTEATIHCTV QEEFTSTSSI RNIGVPLPTV SCFIVEPAES TEKSRDVKIL
PKGEVGELAV GGHQLADGYL NRQEQTASSF IPSPYGLIYR TGDKARITDE GTIEIFGRLS
EGQVKLRGQR LELGEVQSAV LKTPGCHLAV GAVIDSILVV FCVADTGVTE DLIMDHCRSW
LPQFMMPGEL VLMDEFPRLP SGKVDTKRLK AEFIEQKAGK GQGNSSAGLS DTEKTILQVI
SDTLGAEANY DMTLASAGID SLVAIKLASS LRSSGFSVSV AELLSMQTIA QVCSAVQPLS
FPVHNEAPLV DIHLVDKWAL IEESNTALQN DLELVEDVLL CSPLQVAMLS ETAQRPEAYW
NEIELEATPG ITVTQVYDAF HLLAGQRDIL RAGFVSWNGS FVSPIFASLR FDQIEVVEEF
RRLELSGDEA LLHPLRVQIQ QARVDAGPRI LIDIHHATYD GWSMDIILSD LTDIICERPL
PHRPQFSNLL AYTSNIPRDE LDNARSFWAE YLVDWNKPSR PKLSARPAEL DETLSLKEQL
DISSITAKDI LTSTKYGAQV YFQAALALIW GSIVGTSDVL LGSVTSGRTI PVKDIEEIVG
PSIASLPLRV DIESSATILD VLRSINESNR KIMEHCSLPL SEIRKLSRLQ AAESLYDVLF
VYQESLYTKS RKEAAIREIR HLDHLETKLL LEVEPNDAGF SIQATYHTDW FPSPMVEILV
EQVKTVFQYI IQHPDESIRR VREAITIEAS VANTSPEKLQ DEVDLATLFE AAAAKSPEAD
AICFSRSLSE VPMIADTMSY ESLNQLSNQI ARFLLDQGTE PGQVIAIVMQ KSPLLYASVL
GIIKARCAYL PLLPSTPIDR VKDIFGSGNI GHCVVDSASI HTLRDIADVQ FLDVESAPLD
DFANNNLDMA VDTSRLAYVI YTSGTTGVPK GVAVSQKNIV NNVTYLASIY PSTQRKAGRL
LQACSQAFDV SVFEIFYTWH AGMCLCAAVN DDLFEDLEHS ICQFQITHLS LTPTVASLID
PKNVPDVEFL VTAGEPMTLA VLDTWGDLLW QGYGPSETTN ICSVKRMKPG EYIEHLGWCF
PNTSIFVLYP DGLSAVPIGW IGEFCFAGEQ VADGYLNMPD LTAEKFIKHP HYGLIYRSGD
MGRMLPDKSL LILGRIDDQL KLKGQRIEAG EVNSVITSDP SIHDAVTTLV RRENGTADQL
ASFYTFSQGP DEVFKTLDPD TESHRSLYAT LLSKLPSYMV SSYLIPVSRI PLTSSGKVDR
RKLQSSFEAL SQEYLETVSS TVTIQDDAEW SESETKIAEA ISQSLGVPQS DIGRWTPFAT
IGLDSISAIG VSRSLNSQLE HRVPISAILQ HSSVAQLARF VQDGTARNGP VKDLISFSDS
FTEQVYKSFA QGPYSIGQIL PCSPLQEAML SQGSYYNRIL LRLHRPVDEM KGYWDEMTLR
HSILRTCFVT TDDVKFPIAQ VVLDNWIIQW NEFTVATSLD EAVHQHLAGV PDPLDTQVPP
LSFAIIQQED WIFLSFICHH ALYDGIAMEN LWREVEALAH GEQLLPPVSY TPFLQGALYL
PDDVESFWSN HFRGYDPLNL FTKPSGSQIV QRTHKETLEM SYGEVKTRLR SLGVSLLSIC
QAAWADTLVV CSASTDVCFG LVMNGRTLDI EGLDRLVAPC FNTIAIRKDV STSSRNIDLA
KSFQRLNSDV QRYQFSPLRL IQKLGAKEGG RLFNTLLLLQ SPLQDMDAGV WTLEEDNGNM
DIPVVCEVVP HPSSDSIAIN LHYDEGALSE DVASTLAEIF KNFFRAILDH PSAALPDRSH
LKPAHLSVLS TVTAKRNTLV ASEEVELNDA EWTELQKQIR QVLSSLSGTP IQKIHPETSI
FRLGLDSINA VQVAAMLRRG GVVVSASDVI ECQTCVKLAE RISAVPKDGK DASGYDFDKF
SQEISAQIQD QVPDAATIEA VLPSTPLQCA MLVSFIQSRG QNYLNLLSYA VDKAISEDDL
IRAWKALRTH HSMLRTGFTP VQHRHSSFAM LRYPDTLEPI ETANHISRLE SQEKLQEWKE
KEAAAILSNL HLPPWRVSLA QVNGGLTMNV LLHHALYDAQ SLDQMMGDLS RLLAGHKIDQ
RSIEPALNVI LTRSLNDEGA AQEFWKEKAD MAVVNTFPIM TPLREDERTM VSHEIKASMT
LSSLQMATTK QGVSIQAVIQ AAWTRILSSY LGEESVVFGV ILSGRGTEET RDAPFPCMNT
IPVIAVNQSS NTELTRYMME YNANAHRHQY TPLTQIQKWL GHPATPVFDT LLVYQKLETE
PGITKRWKLV KDDATVDYPV SLEVKPHNDE IQICITFFSD ILPKEQAELL VRQFDAMMTH
IATEPDGDED GIYRLKPDLF AITPPVSPEL RAPVQFLHQF VEERAISHPN DVALEFVERF
DGSRPVKQVW SYAEFDAMGN KMANLLMQVA PIGSIIAIHF DKCPEAYISI LGILKAGCAF
VALDPSAPSD RKEFILRDSM APCLLTTNDG KIDFEIDVDV VRIDLEDIEP ISDQPRDLRG
AFTPDATCYC LYTSGTTGTP KGCEITHDNC VQAMMAFQDL FRGHWSDDSR WLQFAALHFD
VSVLEQYWSW SVGITVVAAP RDVILDDLIA SINNLEITHI DLTPSLARLT HPDEVPGLCR
GVFITGGEQL KQEILDAWGP KAVIYNAYGP TEATIGVTMY QRVPINGRPS NIGKQFLNVG
SYVFRKGTEI PVLRGAVGEL CVSGRLVGKG YLNRKELTEE RFPTLSEFGE RIYRTGDLVR
ILHDGCFDFL GRADDQVKLR GQRLEIGEIN HVIRTGVSEI KDVATIIIKH ASSGKDVLVS
FLVGEPQPKA VLAPLADETN LGAKAKEACR AKLPGYMIPT YFLALPYIPL SPNNKVEAKE
LKKLFNGLSH EQLMDLTAPK AAPRSVNGET GHKVIQVLSD FTGVASGTID GETSIFDLGV
DSISALQLST LFKEREFVAC SPAILLRNPI IADLVAALSE QISSSHKDSR VKESQQLIQA
CHHRYRALAC SVLHIQGEYI EYIAPCSALQ QGIISKSVTD EIRGTYFNSF VLSLSDDASE
ERIKAAWTEL IASESILRTA FVNTTEGYNE EDTKAFLDNQ WQQWVQQNSE HIVAPLEAIL
IKGPSFKKLV IHIFHAIYDG NSFDLMLKRL KSIYAGRFTV PSPSFIEALS HGPLWRHDDC
HKYWESHLQG WTSSSTLQLS SPHNRAASET RIIDGSPLED ARRKQKVTLQ PVIMALWTSV
LQKYYPDGLT VGLIVSGRSI DLPGVENTIG PLFNTMPFFN KTLSGQSWAS LIRKCSEFST
SILPFQHVPL KSIQKWCTGG RQLFDSLFVF EVERKTKGQP NLWQIEDGPL NPDYPLALEA
KRLLNGNVQL TLVAQRYVAD ESKLQEMLDE LEENIRLMAA DVPFPKSTEG DEMPLSVEQN
GFKSANDEDD QIFEWTDQAL GIRDAIASLS GLDDAEISAA KTILELGLDS IDVIQLSARL
KQRGILLPAS QIMRQQTIAK MVASIETQHS GELSNGDTDK KFDELERKLW SYAKKVGLNT
SDIEAILPPT PLQESMAAGM IHSDFEWYFN HDVLEVSAGT DVEKLREAFL VVIDRSPILR
TGFLEVDDLQ LEMAYCQVVR KHWDQKVESA EVEGLSEMGA HIEDAKQIAR ANSGVDALFQ
LRFVRCKEMT FVLVSIAHAL YDGWSLSLLY RDLEAAYHGE LQTRTSAKPF LQRILASATD
DARRFWAGYL DGVTPSILPE QPENDVDKAL YRSEYPASKK MSEISSFCKK QGISLQVLCQ
ACWALELAHR IKTLDVTFGV VMSGRDFEEA EDLMFATINT VALRCILHGT TISFLRYLEA
SMADIRDHQS YPLRKIQNAV QLSSGELFNT LFMLQKSPYS SSANPLLKSV DGASAVDYPV
SVEAEAVGDK LVWRVACQSQ FISEDGAEQL LEDLDRVLVF LTHSKEPEIL SFEENRVSIA
GLSFISLAGD RGQAIEDTEN ELDETALTIR KVLSYVSDIP EESIRPQSNL YHLGLDSISA
IKLSSLLRKE GLYLNPRDFI RATSISQMAQ LSAPLQTNGS TIHPKETAWT PGDDIDVDGL
FNSAHISKDD VEVILPALPM QVYMISAWQN AEGNVFYPEF RYLVEGIASV EDVQLTWQSL
VAQTPILRTA FIATDSPQQP FLQAILKTSH QSDDSAIRPM ASLDAVRRED GKIAIRLKIH
HALYDGVSIP VIINRLSELL KGQTLAVEQG IDEWSRYAIQ PSFEDSRQSR RAFWTSYLQG
CSSDGDSSAS IMASKHRVSH IRRSAVSNIA YLQTRAKDKG VSLQALFFAA YAKILAAGSS
GVTSDDAKKT VVFGIYLANR TDETLPLPFP TLNLVPLRVR LAPADSILEI ADKIQSDIHL
IAVDGRADVG LWEVAAWTGV KITSFVNFLS LPDAISETPN GNSRNIELIQ VQDEEFSQEA
EEVAFHPSLL KNPVRDAFPA AIDIEASIQG KSLDIGIFGS RQRLSDQGAI HLVDEIISYM
KQLNGEESAE NGEDGSEMES WASTWVTGSS KKK
//
