ID A0A0F9ZC89_TRIHA Unreviewed; 1814 AA.
AC A0A0F9ZC89;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=RasGEF domain-containing protein {ECO:0000313|EMBL:KKO98066.1};
GN ORFNames=THAR02_09835 {ECO:0000313|EMBL:KKO98066.1};
OS Trichoderma harzianum (Hypocrea lixii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=5544 {ECO:0000313|EMBL:KKO98066.1, ECO:0000313|Proteomes:UP000034112};
RN [1] {ECO:0000313|Proteomes:UP000034112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA Pe M.E., Sarrocco S., Vannacci G.;
RT "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT T6776.";
RL Genome Announc. 3:E0064715-E0064715(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKO98066.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JOKZ01000466; KKO98066.1; -; Genomic_DNA.
DR OMA; ICNYATM; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000034112; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000034112}.
FT DOMAIN 394..521
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1567..1810
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1159..1180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1343..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1347..1363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1429..1444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1814 AA; 199724 MW; 8E229D891E49A663 CRC64;
MDAAEPPLVA ARPSHALRSK PSMKRRKAPP LRTIQTAAQG AGAAKDDAIG RIQPFGDLVD
AKERSPPKPL GKVTRKVSAT GRPIVPLTEQ KSISRSRTLS IGKRDEERDR WDVAPDGASA
GREGRQFTVA NVGNNGKLFL RPSVRRGNKR YPQPNFTFPI TPPGTAGLEG AYPDNRDEPP
SLTADHHENQ FTPTPRTSII PPAYAPDLSN LASQHRRAVS DGTIRDFNSP TGTDTDGYRI
VITKPTHGDD HRPKTTEHLE DLDVDGVPML NINIPSWKLG TPRFSTRGTP MLRGSSYAPT
DDFRSNSRAS MYHSSERSLG APLSGLRSRR PSHLVPPKLR FPRTSHASSQ ASTRPPRVVP
STYASTHLII EPDMFDELTF KPTCDDKLIV RYSPSGSVTA ATPSRLVAEI TSPSFLDYEL
ISDFFLTFRA FLEPDILLRM LMARLRWALE RTDEIGMIVR VRTFVAMRHW ILNYFVDDFV
LDYDLRVIFC ILLNDLFDEL SQDARERRVQ LKILTELKKC WRRICAHYWD GPDFDDSLGP
GAPVAPGGIA GYRDPNLDPT FWEREGVDPP QWHAVSGIPD GLSDAPNSSV EDVPTTARFG
DFTVSDHRPG TPEHQIITTT MVSNGPASPL SIASMDIVSC SFPTKNVRSL NPNSSQPLAA
HPVYSTSPIL PPGAIATTPK ALSGKRVRPA QSHGRNNSAT DSIRAPGSDS SSSQDVDLHM
ILQSAGNLVR GNILPPGQPF VDIESGTPTG DNRQTTIFQP VSRNAPKDRI FGVAMSGSGM
KKFLGGVRRA LNNRGQWSSG SHTSLPAVAS LSAHTVSIDR LPGTAIITQG GYAQTTSRPQ
VRIDVLGAEV AEDFKRAIRE EEEAAEAERL GVPRPAPTPS STRRRRHMEY SVAHMESSTG
DYVPQNRRSR PMSDMGLTTG SQSIVIVDDT VPFDMPGIRD RLPAATFNPS AGGLSVGSFL
TAGGDPTPPT TPPAQPMAGT PRRSSYLLDQ LVALPSASQG ESFPPFVPDM ATLGHSHTYS
QGQSDDASRV SFSTMRRSIQ RRPPLSRGTL RVHRRNQSTN TQQSSYSFRR HASFGSHLER
HSTARSFDAT TDSSLLDREY EVPAVEPPRM LRRRPGGYLR AAVNNAGGLN NQPTVRKSHS
VGSLTNYTDS VRSSYLLGTH AEQDDDDRSF SGAGDHPRER HEIFSVGQLT EKPAKRHLSL
FSTHSSKPIM RPSFEIEARK LAQIPDEDDG GIESALLKLE GKYQPKPKSF EQLRQTAMID
ANEFGGQAAT ANSYASENQS QESEAGGMDD EYQSWDKGKQ PQDTEHNRDT LIAHSRVATL
ETRSFLTADS DESYCSIPLL ERGLTDDGQS NRGTSQWTNR SVLRGSSDED DATTSDLVAT
RSHQASHQAS SSHLSYDFVQ KTESIERVKT RKTASLPVAE DQTFLEDASV GGSDLSSELS
PSEDEGSNNY RERAGVFSIS SQPHPFGDPI ATPRSNSSSA PMTLAQALAM SPVMMSPVLT
NTERTLDLDQ IWTRTPLPLS PEIFQDGPNT AEHVPPRTSE ALPPLPQPET PNTLKYSIHL
PFILAFESDI LAQQFTLIEK DALNDIDWRE LIEMNWRNAT SNDSRSWVDF LRNTNAHGVE
VVVARFNIMV KWAISEIVLT QHIEERARCI IKLIHIAAHC RRYRNFATLA QLTIALSSAE
VARLSKTWDL VPARDLNTLG ELEALVTPSR NFYSLRAEME VGSDGGCIPF VGIYTHDLLF
NAQRPSEIAS SPTTPPLINF ERCRIGAAVV KTLLRLLEAS TRYTFQPIEG ITERCLWMGA
LNDDEIRRHS EALE
//
