ID A0A0F9ZPY1_TRIHA Unreviewed; 1097 AA.
AC A0A0F9ZPY1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=ATP-dependent RNA helicase DOB1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=THAR02_05572 {ECO:0000313|EMBL:KKP02322.1};
OS Trichoderma harzianum (Hypocrea lixii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=5544 {ECO:0000313|EMBL:KKP02322.1, ECO:0000313|Proteomes:UP000034112};
RN [1] {ECO:0000313|Proteomes:UP000034112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA Pe M.E., Sarrocco S., Vannacci G.;
RT "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT T6776.";
RL Genome Announc. 3:E0064715-E0064715(2015).
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKP02322.1}.
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DR EMBL; JOKZ01000155; KKP02322.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F9ZPY1; -.
DR OMA; IMLKNYN; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000034112; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000034112}.
FT DOMAIN 173..329
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 409..613
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 123867 MW; 9B2D3B3599636D94 CRC64;
MDDLFDVFEG KAEPQSSSED ERTPQKSRSR AQSKKRKADE AMNGNADADV DANNDDADVG
MADAAETSRD EDSEGEEDSE TPEKQDKKRR KKADGAGPVM TDNFQTAESR EVAGASTFVS
QDSSLVLSHN IQHQVALPPD LNYEYIPLSE HKSPEEPART YPFKLDPFQS LSVASIEREE
SVLVSAHTSA GKTVVAEYAV AQCLKRNQRV IYTSPIKALS NQKYRDFEAI FGDVGLMTGD
VTINPTASCL VMTTEILRSM LYRGSEIMRE VAWVVFDEIH YMRDKTRGVV WEETIIMLPD
KVRYVFLSAT IPNAFQFAEW IAKIHHQACH VVYTDFRPTP LQNYFYPAGG KGARMVVDEK
GSFNEENFNL VMAEVEEKKG ADPADPTAKM KGKGKNKKTN KGGADEGSDI NKIIRMTVRK
NFNPVIVFNF SKRECENMAL KISNLNFNDD SEKAMVNKVF QSAIDSLSEQ DRELPQIMNL
LPLLQKGVGV HHSGLLPILK ETIEILFQES LIKVLFATET FSIGLNMPAK TVVFTQVTKW
DGVQRRPITS SEYVQMAGRA GRRGLDARGV VIMMIDDKLE PEVAKQIVTG QQDRLNSAFY
LGYNMILNLL RIEAISPEFM LERCFHQFQN AASVPSLEKD LMALQQEKDA LTIPDEATVK
DYYTIRQSLN TYTKDMRAVI QHPNYCLPFL QPGRLVQIHN VKESAEKIGG GLDFGWGVIT
DAYSRRPPKL GEPDYPPQES HIIEVLLYIS KHSAEIIPGQ LSGDMPPGLK PSGEEDGMFA
VVPCLLTCIK AISQIRIFIP KDGLKSDDER KDASKALSEV QRRFPDGVPI LDPLENMDIS
DESFKQLLRK IEVLESRLVT NPLHLSPMLP SLWDQYHAKV QILDKIKEKK KEIAKAHSIA
QMDELKSRKR VLRRLGFIND AEVVQLKARV ACEISSTEGH ELLLSELLFD RFFNEMTPEA
IAAVLSCFVF DEKLEAQALK EELQKPFREI QAKARMIAKV SQESKLDVNE DEYVQSLKWQ
LMETVYAWAQ GRTFAEICKM ANVYEGSFIR IFRRLEELLR QMAQAAKVMG NDDLTKKFDE
SLQKIRRDIV AAQSLYL
//
