ID A0A0G0C0L3_9BACT Unreviewed; 650 AA.
AC A0A0G0C0L3;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Peptidoglycan glycosyltransferase, penicillin-binding protein 2 {ECO:0000313|EMBL:KKP44720.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:KKP44720.1};
GN ORFNames=UR34_C0001G0066 {ECO:0000313|EMBL:KKP44720.1};
OS candidate division WS6 bacterium GW2011_GWC1_33_20.
OC Bacteria; Candidatus Dojkabacteria.
OX NCBI_TaxID=1619089 {ECO:0000313|EMBL:KKP44720.1, ECO:0000313|Proteomes:UP000034302};
RN [1] {ECO:0000313|EMBL:KKP44720.1, ECO:0000313|Proteomes:UP000034302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKP44720.1}.
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DR EMBL; LBOV01000001; KKP44720.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0C0L3; -.
DR PATRIC; fig|1619089.3.peg.66; -.
DR Proteomes; UP000034302; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000313|EMBL:KKP44720.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000313|EMBL:KKP44720.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..262
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 305..634
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 650 AA; 71656 MW; A0D5B096BC0A8D88 CRC64;
MPKLYFDEKV NKKVLHKPIN SWRGDSSVNL KSRFLTKIVN GNGEKISLSA WNFIYAFVLF
GLVFTVLVFS IAKLQIVDGE EMLARSERNK VRITSVKAYR GVIFDSNGEK LVENVPSMNV
YVSIEPFIEE EQWESSDTEG NIYDSLSDRV FSIYKDSIYT SKILLARDID NDMAIKIKSH
EQELLGVSID NGSKRKYIYK DIFTHILGYT GETSAEDIKK YTNLSSGGIV GKLGVERYYE
EKLQGTHGKQ AEEIDAFGRS VSAEPYMLSE PVSGQNLYLT VNKDVQQKLY ELLGEAVTKN
SAAGGAAVIE DVNTGEILAI VSYPSYDNNL FIGGISQEDY SKILNDKGNP LLDRALSAQI
PPGSTFKTIV AAAGLEAGVI TKNSTYVSRS GYTFSNGAPF QEFRNSSYGT LNVVGALTVS
SNIFFCELIR DWRMQELVPY LEAFGIGQYT GIDIPGEAPG RLPSPENKIK LANTTSPWLE
PVWYPEGDSC NSVIGQGITL TTPIQMSNWI AAIANGGTLN TPHVAKKFVD ENGFEYPVEV
EPIKREIASK SSLDIVKKGM WETVNGSRGI VGSLSNTGTT VAAKTGTAEF GKQNSKGVYE
DTHAWTTGFF PYENPKYSFS LLLEDGGMSS NASAVMRDMI SWMVQNGFVK
//
