ID   A0A0G0C131_9BACT        Unreviewed;       507 AA.
AC   A0A0G0C131;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020675, ECO:0000256|RuleBase:RU000644};
GN   ORFNames=UR72_C0006G0014 {ECO:0000313|EMBL:KKP75118.1};
OS   Parcubacteria group bacterium GW2011_GWC1_35_21.
OC   Bacteria.
OX   NCBI_TaxID=1618892 {ECO:0000313|EMBL:KKP75118.1, ECO:0000313|Proteomes:UP000034759};
RN   [1] {ECO:0000313|EMBL:KKP75118.1, ECO:0000313|Proteomes:UP000034759}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA   Wilkins M.J., Williams K.H., Banfield J.F.;
RT   "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT   radiation of phyla.";
RL   Nature 0:0-0(2015).
CC   -!- FUNCTION: One of the essential components for the initiation of protein
CC       synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC       and promotes its binding to the 30S ribosomal subunits. Also involved
CC       in the hydrolysis of GTP during the formation of the 70S ribosomal
CC       complex. {ECO:0000256|RuleBase:RU000644}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|RuleBase:RU000644}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKP75118.1}.
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DR   EMBL; LBQG01000006; KKP75118.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G0C131; -.
DR   STRING; 1618892.UR72_C0006G0014; -.
DR   PATRIC; fig|1618892.3.peg.515; -.
DR   Proteomes; UP000034759; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd01887; IF2_eIF5B; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 2.
DR   Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR000178; TF_IF2_bacterial-like.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   NCBIfam; TIGR00487; IF-2; 1.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50447; Translation proteins; 2.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW   ECO:0000256|RuleBase:RU000644};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU000644}.
FT   DOMAIN          10..184
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51722"
FT   COILED          315..342
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   507 AA;  56647 MW;  058764F2CA9420B9 CRC64;
     MDKKEEKSIT RPPVVVIMGH IDHGKSTLLD YIRKTNIVEG ELGGITQHIS AYEVIHSPLN
     SEQEKKITFI DTPGHESFSK MRERGAQIAD IAVLIVSAED GVKPQTIEAW KTITANKIPC
     IVAINKIDKT NANIQKTKTE LAENEIYLEN YGGKIPFVEI SAKNGTGVDD LLSLINILAE
     MENFKGDKDE NASGLVIETN LDSKRGIQAT LIIKNGSLRK GMIVVVEDSV CSTNIMENFL
     GKIINEAAFS SPIRLIGFDK MPRIGAEFKS FKTKKEVEKY IREFDFSRSD LGDSKRSDLF
     PPEDGTKKII PIILKADIAG SIEAIEKEIN KIRNENAEFK IVQKGVGPIS ESDIKTISGG
     ENILVIGFNV KIDKSAVELA DKRGITISFF DIIYKMTEWL EGEMEKRRPR IETIETTGSS
     KVLKVFSHTK ERQIVGGRVL KGRIVLDKIV KIMRRDFEIG RGRIVNLEKA KMKVKEVEEG
     TEFGMMIESK TEIVEGDVIE SFNVTQK
//