ID A0A0G0NGA2_9BACT Unreviewed; 821 AA.
AC A0A0G0NGA2;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=UT39_C0002G0027 {ECO:0000313|EMBL:KKR11846.1};
OS Candidatus Woesebacteria bacterium GW2011_GWA1_39_21.
OC Bacteria; Candidatus Woesebacteria.
OX NCBI_TaxID=1618550 {ECO:0000313|EMBL:KKR11846.1, ECO:0000313|Proteomes:UP000034246};
RN [1] {ECO:0000313|EMBL:KKR11846.1, ECO:0000313|Proteomes:UP000034246}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKR11846.1}.
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DR EMBL; LBWP01000002; KKR11846.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0NGA2; -.
DR STRING; 1618550.UT39_C0002G0027; -.
DR PATRIC; fig|1618550.3.peg.125; -.
DR Proteomes; UP000034246; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 142..317
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 404..676
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 821 AA; 90887 MW; 4B60082D737AC8B4 CRC64;
MSIKMKNKKV LKKRKALVEH TKIVDENLTK TKTSTLKKLS SFFWTVFQKV GKYLFLSIYH
LLKYIYQLPL KIFYKRKGPN PRKDQKAGKS PLANNRLRFT LFFLVLAAAV VFFTWLFWGL
PLPTKLLQTQ VPVSTKIYDR TGKPIYEIYT DKRSTPVDVD SLPSYVVDAT ISIEDKDFYK
HHGISLTGIA RAAYNTVFKQ KLQGGSTLTQ QLVKNALLTP DRTIKRKLRE IVITVFVEAM
YSKKQILSMY FNQIPYGSTA YGIGAASELY FNKEAKDLTL SEAALLAGIT AAPTKYSPFG
AHPEIAKTRQ ELVLRRMVED GLISSGQADE ANSEKLNYAE PEKFKAPHFS LWVKELLADK
YGDAVVEQGG LRVITTLDLD LQEYAEATVS AELAKLKKQN VRNGAVLVTR PKSGEILAMV
GSKDYFAKDE DGKFNVILAN RQPGSSIKPL NYALALRDKK ITLSTPLADV PTCFNVFGQK
EYCPVNYDGT FHGAVQPRFS LGNSYNVPAV RVLALNGLEN FIYFATNMGI TTLTDPKNYG
LSLTLGGGEV KPYDMAVSFG VFANAGVKVP LNPILKVTDW KGKIYEDNNP NDVDGQRILD
PDATFLISHV LYDNNARVAA FGPSSYLVVN GHPEVSVKTG TTNDRRDNWT IGYTPQVVVV
VWVGNNDNSA MSGAVSGVSG ASPIWNKIIK YTLDKAEKGF YNQDDGHAWP GQPDNVVGRN
VCATTGNLPA DESNPGCPTR FEYFLKDNIG ANVESGQRDL QIDKTTGMLA FPDTPPENIE
TQNHPFLLDP LGTLVCLDCP IASESAKINY PLVNTTSTSV P
//
