ID A0A0G0XI00_9BACT Unreviewed; 315 AA.
AC A0A0G0XI00;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN ORFNames=UU81_C0006G0015 {ECO:0000313|EMBL:KKS24499.1};
OS Microgenomates group bacterium GW2011_GWC1_41_8.
OC Bacteria.
OX NCBI_TaxID=1618519 {ECO:0000313|EMBL:KKS24499.1, ECO:0000313|Proteomes:UP000034304};
RN [1] {ECO:0000313|EMBL:KKS24499.1, ECO:0000313|Proteomes:UP000034304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS24499.1}.
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DR EMBL; LCCB01000006; KKS24499.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0XI00; -.
DR Proteomes; UP000034304; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 83..285
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 315 AA; 36226 MW; BE4F6D4B43821CF8 CRC64;
MPRQRKISYN YKTSESIEKK SIKPVIYFLL LFFTVFVVFN MRNTTTKASN VLPFNAVSDE
PQTLSELSLA IRNRIAEEEG TYSIRFEDFG TKNAFGINDE PVVTAASVIK IPALAALYYL
AEQRDIDLNE VITIPESDMQ RWGTGIIRYQ DAGATYTIRE LAQVMMEHSD NTAVYVLANR
VIGLERLQEL IDSWGLSNTN YLENNISNKD MNKVMRMMYS GELVKDEELN VEMMGWMDDS
DFEERLPKYI PEEVSVYHKI GNEVRITHDV GVIDLPEKPY YLGVLGIEIP DHEHATEVIA
QISQMVFEYQ SRMNQ
//
