ID A0A0G1DJP2_9BACT Unreviewed; 700 AA.
AC A0A0G1DJP2;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=UV41_C0006G0028 {ECO:0000313|EMBL:KKS71076.1};
OS Candidatus Daviesbacteria bacterium GW2011_GWA2_42_7.
OC Bacteria; Candidatus Daviesbacteria.
OX NCBI_TaxID=1618425 {ECO:0000313|EMBL:KKS71076.1, ECO:0000313|Proteomes:UP000034785};
RN [1] {ECO:0000313|EMBL:KKS71076.1, ECO:0000313|Proteomes:UP000034785}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS71076.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LCEJ01000006; KKS71076.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1DJP2; -.
DR PATRIC; fig|1618425.3.peg.147; -.
DR Proteomes; UP000034785; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02074; PBP_1a_fam; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..256
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 347..621
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 652..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 76837 MW; B9936818904B5EDB CRC64;
MAFKRIKNHT VYSGHSTGFR HSLRRAKFLS RFSTLMLTMI LGGIAVLILV IVVFATQVPS
PRELTSREMA QATKIYDRNG ELLYDIFKDQ NRTPVKLSEV PLVVKQATIA IEDKDFYKHQ
GFSPLGITRS VFDLIISRKV EGGGSTLTQQ LVKNALLSGE RTLTRKLKEF ILAIQVERAY
GKDQILEMYL NEIPYGGTAY GIEAAANLYF GKHAKDLDLA ESSLLAGLPQ RPSVYSPYGT
HPELSKERQV EVLRRMTEDG YITKQQAEEA KNKELTYRTK QNEVGFKAPH FVLYVKQKLI
EQFGDKLVEQ GGLKVTTTLD YKLHEESQKV VKDEVSKLKN YKVGNAAAVV LDPKNGQILA
MVGSKDYFAD SEPENCSEGE SCVFEANVNA TLSLRQPGSA TKPITYSAAL QKGYTASTVL
VDVKTEFPGG DQPAYIPVNY DGQFRGPVQV RYALGNSYNI PAVKTLALTG VKNVMELGYR
MGLSTWEPTT ENINNAGLSL TLGGREVRLL DLTSAFGVLA NSGVKQDPVS ILKVSDAKDK
TLYEYRQSDG TRIFEEGIAF IISNILSDNG ARSAAFGTNS VLNISGKTVS VKTGTTDEKK
DNWTIGYTPS VVVGVWVGNN NNAVMNPAIA SGITGASPIW QKIMIAALKG KDDEKPEAPG
NVSYVEVDGL MGGKPRDGSP TRREYYIKGT EPSSASSVYR
//
